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Results: 1 to 20 of 134

1.

A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region.

Moroco JA, Baumgartner MP, Rust HL, Choi HG, Hur W, Gray NS, Camacho CJ, Smithgall TE.

Chem Biol Drug Des. 2014 Nov 6. doi: 10.1111/cbdd.12473. [Epub ahead of print]

PMID:
25376742
[PubMed - as supplied by publisher]
2.

Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells.

Zhang X, Simerly C, Hartnett C, Schatten G, Smithgall TE.

Stem Cell Res. 2014 Nov;13(3 Pt A):379-89. doi: 10.1016/j.scr.2014.09.007. Epub 2014 Sep 30.

PMID:
25305536
[PubMed - in process]
Free Article
3.

Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.

Moroco JA, Craigo JK, Iacob RE, Wales TE, Engen JR, Smithgall TE.

PLoS One. 2014 Aug 21;9(8):e105629. doi: 10.1371/journal.pone.0105629. eCollection 2014.

PMID:
25144189
[PubMed - in process]
Free PMC Article
4.

Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment.

Alvarado JJ, Tarafdar S, Yeh JI, Smithgall TE.

J Biol Chem. 2014 Oct 10;289(41):28539-53. doi: 10.1074/jbc.M114.600031. Epub 2014 Aug 13.

PMID:
25122770
[PubMed - in process]
5.

Human trophoblasts confer resistance to viruses implicated in perinatal infection.

Bayer A, Delorme-Axford E, Sleigher C, Frey TK, Trobaugh DW, Klimstra WB, Emert-Sedlak LA, Smithgall TE, Kinchington PR, Vadia S, Seveau S, Boyle JP, Coyne CB, Sadovsky Y.

Am J Obstet Gynecol. 2015 Jan;212(1):71.e1-8. doi: 10.1016/j.ajog.2014.07.060. Epub 2014 Aug 6.

PMID:
25108145
[PubMed - in process]
6.

The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner.

Tarafdar S, Poe JA, Smithgall TE.

J Biol Chem. 2014 May 30;289(22):15718-28. doi: 10.1074/jbc.M114.572099. Epub 2014 Apr 10.

PMID:
24722985
[PubMed - indexed for MEDLINE]
7.

Synthesis and structure-activity analysis of diphenylpyrazolodiazene inhibitors of the HIV-1 Nef virulence factor.

Iyer PC, Zhao J, Emert-Sedlak LA, Moore KK, Smithgall TE, Day BW.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1702-6. doi: 10.1016/j.bmcl.2014.02.045. Epub 2014 Feb 26.

PMID:
24650642
[PubMed - in process]
8.

Small molecule inhibitors of the HIV-1 virulence factor, Nef.

Smithgall TE, Thomas G.

Drug Discov Today Technol. 2013 Dec;10(4):e523-9. doi: 10.1016/j.ddtec.2013.07.002. Review.

PMID:
24451644
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Development and validation of a high-content bimolecular fluorescence complementation assay for small-molecule inhibitors of HIV-1 Nef dimerization.

Poe JA, Vollmer L, Vogt A, Smithgall TE.

J Biomol Screen. 2014 Apr;19(4):556-65. doi: 10.1177/1087057113513640. Epub 2013 Nov 26.

PMID:
24282155
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen.

Trible RP, Narute P, Emert-Sedlak LA, Alvarado JJ, Atkins K, Thomas L, Kodama T, Yanamala N, Korotchenko V, Day BW, Thomas G, Smithgall TE.

Retrovirology. 2013 Nov 14;10:135. doi: 10.1186/1742-4690-10-135.

PMID:
24229420
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity.

Perrone R, Nadai M, Poe JA, Frasson I, Palumbo M, Palù G, Smithgall TE, Richter SN.

PLoS One. 2013 Aug 27;8(8):e73121. doi: 10.1371/journal.pone.0073121. eCollection 2013.

PMID:
24015290
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

c-Yes tyrosine kinase is a potent suppressor of ES cell differentiation and antagonizes the actions of its closest phylogenetic relative, c-Src.

Zhang X, Meyn MA 3rd, Smithgall TE.

ACS Chem Biol. 2014 Jan 17;9(1):139-46. doi: 10.1021/cb400249b. Epub 2013 Aug 15.

PMID:
23895624
[PubMed - indexed for MEDLINE]
13.

A dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoter.

Perrone R, Nadai M, Frasson I, Poe JA, Butovskaya E, Smithgall TE, Palumbo M, Palù G, Richter SN.

J Med Chem. 2013 Aug 22;56(16):6521-30. doi: 10.1021/jm400914r. Epub 2013 Aug 6.

PMID:
23865750
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.

Engen JR, Wales TE, Chen S, Marzluff EM, Hassell KM, Weis DD, Smithgall TE.

Int Rev Phys Chem. 2013 Jan 1;32(1):96-127.

PMID:
23682200
[PubMed]
Free PMC Article
15.

Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity.

Emert-Sedlak LA, Narute P, Shu ST, Poe JA, Shi H, Yanamala N, Alvarado JJ, Lazo JS, Yeh JI, Johnston PA, Smithgall TE.

Chem Biol. 2013 Jan 24;20(1):82-91. doi: 10.1016/j.chembiol.2012.11.005.

PMID:
23352142
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Structure and dynamic regulation of Abl kinases.

Panjarian S, Iacob RE, Chen S, Engen JR, Smithgall TE.

J Biol Chem. 2013 Feb 22;288(8):5443-50. doi: 10.1074/jbc.R112.438382. Epub 2013 Jan 11. Review.

PMID:
23316053
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors.

Panjarian S, Iacob RE, Chen S, Wales TE, Engen JR, Smithgall TE.

J Biol Chem. 2013 Mar 1;288(9):6116-29. doi: 10.1074/jbc.M112.431312. Epub 2013 Jan 9.

PMID:
23303187
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Individual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.

O'Reilly LP, Zhang X, Smithgall TE.

Cell Signal. 2013 Apr;25(4):860-6. doi: 10.1016/j.cellsig.2012.12.009. Epub 2012 Dec 22.

PMID:
23266470
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Small-molecule inhibitors of the c-Fes protein-tyrosine kinase.

Hellwig S, Miduturu CV, Kanda S, Zhang J, Filippakopoulos P, Salah E, Deng X, Choi HG, Zhou W, Hur W, Knapp S, Gray NS, Smithgall TE.

Chem Biol. 2012 Apr 20;19(4):529-40. doi: 10.1016/j.chembiol.2012.01.020.

PMID:
22520759
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck.

Pene-Dumitrescu T, Shu ST, Wales TE, Alvarado JJ, Shi H, Narute P, Moroco JA, Yeh JI, Engen JR, Smithgall TE.

BMC Chem Biol. 2012 Mar 15;12:1. doi: 10.1186/1472-6769-12-1.

PMID:
22420777
[PubMed]
Free PMC Article

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