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Items: 1 to 20 of 339

1.

An Internet-Based Physical Activity Intervention to Improve Quality of Life of Inactive Older Adults: A Randomized Controlled Trial.

Broekhuizen K, de Gelder J, Wijsman CA, Wijsman LW, Westendorp RG, Verhagen E, Slagboom PE, de Craen AJ, van Mechelen W, van Heemst D, van der Ouderaa F, Mooijaart SP.

J Med Internet Res. 2016 Apr 27;18(4):e74. doi: 10.2196/jmir.4335.

2.

Genetic and environmental influences interact with age and sex in shaping the human methylome.

van Dongen J, Nivard MG, Willemsen G, Hottenga JJ, Helmer Q, Dolan CV, Ehli EA, Davies GE, van Iterson M, Breeze CE, Beck S; BIOS Consortium, Suchiman HE, Jansen R, van Meurs JB, Heijmans BT, Slagboom PE, Boomsma DI.

Nat Commun. 2016 Apr 7;7:11115. doi: 10.1038/ncomms11115.

3.

Assessment of health status by molecular measures in adults ranging from middle-aged to old: Ready for clinical use?

Waaijer ME, Westendorp RG, Goldeck D, Gunn DA, Pawelec G, Stijntjes M, Slagboom PE, Maier AB.

Exp Gerontol. 2016 Apr 2. pii: S0531-5565(16)30088-2. doi: 10.1016/j.exger.2016.03.020. [Epub ahead of print]

PMID:
27045974
4.

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.

van Leeuwen EM, Sabo A, Bis JC, Huffman JE, Manichaikul A, Smith AV, Feitosa MF, Demissie S, Joshi PK, Duan Q, Marten J, van Klinken JB, Surakka I, Nolte IM, Zhang W, Mbarek H, Li-Gao R, Trompet S, Verweij N, Evangelou E, Lyytikäinen LP, Tayo BO, Deelen J, van der Most PJ, van der Laan SW, Arking DE, Morrison A, Dehghan A, Franco OH, Hofman A, Rivadeneira F, Sijbrands EJ, Uitterlinden AG, Mychaleckyj JC, Campbell A, Hocking LJ, Padmanabhan S, Brody JA, Rice KM, White CC, Harris T, Isaacs A, Campbell H, Lange LA, Rudan I, Kolcic I, Navarro P, Zemunik T, Salomaa V; LifeLines Cohort Study, Kooner AS, Kooner JS, Lehne B, Scott WR, Tan ST, de Geus EJ, Milaneschi Y, Penninx BW, Willemsen G, de Mutsert R, Ford I, Gansevoort RT, Segura-Lepe MP, Raitakari OT, Viikari JS, Nikus K, Forrester T, McKenzie CA, de Craen AJ, de Ruijter HM, Pasterkamp G, Snieder H, Oldehinkel AJ, Slagboom PE, Cooper RS, Kähönen M, Lehtimäki T, Elliott P, van der Harst P, Jukema JW, Mook-Kanamori DO, Boomsma DI, Chambers JC, Swertz M, Ripatti S, Willems van Dijk K, Vitart V, Polasek O, Hayward C, Wilson JG, Wilson JF, Gudnason V, Rich SS, Psaty BM, Borecki IB, Boerwinkle E, Rotter JI, Cupples LA, van Duijn CM.

J Med Genet. 2016 Apr 1. pii: jmedgenet-2015-103439. doi: 10.1136/jmedgenet-2015-103439. [Epub ahead of print]

5.

The multifaceted interplay between lipids and epigenetics.

Dekkers KF, Slagboom PE, Jukema JW, Heijmans BT.

Curr Opin Lipidol. 2016 Mar 30. [Epub ahead of print]

PMID:
27031277
6.

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

Kettunen J, Demirkan A, Würtz P, Draisma HH, Haller T, Rawal R, Vaarhorst A, Kangas AJ, Lyytikäinen LP, Pirinen M, Pool R, Sarin AP, Soininen P, Tukiainen T, Wang Q, Tiainen M, Tynkkynen T, Amin N, Zeller T, Beekman M, Deelen J, van Dijk KW, Esko T, Hottenga JJ, van Leeuwen EM, Lehtimäki T, Mihailov E, Rose RJ, de Craen AJ, Gieger C, Kähönen M, Perola M, Blankenberg S, Savolainen MJ, Verhoeven A, Viikari J, Willemsen G, Boomsma DI, van Duijn CM, Eriksson J, Jula A, Järvelin MR, Kaprio J, Metspalu A, Raitakari O, Salomaa V, Slagboom PE, Waldenberger M, Ripatti S, Ala-Korpela M.

Nat Commun. 2016 Mar 23;7:11122. doi: 10.1038/ncomms11122.

PMID:
27005778
7.

Liver Fat Assessed With CT Relates to MRI Markers of Incipient Brain Injury in Middle-Aged to Elderly Overweight Persons.

Sala M, van der Grond J, de Mutsert R, van Heemst D, Slagboom PE, Kroft LJ, de Roos A.

AJR Am J Roentgenol. 2016 May;206(5):1087-92. doi: 10.2214/AJR.15.15251. Epub 2016 Mar 21.

PMID:
26998564
8.

Neo-cartilage engineered from primary chondrocytes is epigenetically similar to autologous cartilage, in contrast to using mesenchymal stem cells.

Bomer N, den Hollander W, Suchiman H, Houtman E, Slieker RC, Heijmans BT, Slagboom PE, Nelissen RG, Ramos YF, Meulenbelt I.

Osteoarthritis Cartilage. 2016 Mar 17. pii: S1063-4584(16)01070-0. doi: 10.1016/j.joca.2016.03.009. [Epub ahead of print]

PMID:
26995110
9.

Effect of calendar age on physical performance: A comparison of standard clinical measures with instrumented measures in middle-aged to older adults.

Stijntjes M, Meskers CG, de Craen AJ, van Lummel RC, Rispens SM, Slagboom PE, Maier AB.

Gait Posture. 2016 Mar;45:12-8. doi: 10.1016/j.gaitpost.2015.12.018. Epub 2015 Dec 25.

PMID:
26979876
10.

Cerebral Microbleeds and Lacunar Infarcts Are Associated with Walking Speed Independent of Cognitive Performance in Middle-Aged to Older Adults.

Stijntjes M, de Craen AJ, van der Grond J, Meskers CG, Slagboom PE, Maier AB.

Gerontology. 2016 Mar 15. [Epub ahead of print]

PMID:
26974848
11.

Low circulating insulin-like growth factor-1 and high density lipoprotein are associated with hair loss in middle-aged women.

Noordam R, Gunn DA, van Drielen K, Westgate G, Slagboom PE, de Craen AJ, van Heemst D.

Br J Dermatol. 2016 Mar 9. doi: 10.1111/bjd.14529. [Epub ahead of print]

PMID:
26959288
12.

Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck.

Li M, Rothwell R, Vermaat M, Wachsmuth M, Schröder R, Laros JF, van Oven M, de Bakker PI, Bovenberg JA, van Duijn CM, van Ommen GJ, Slagboom PE, Swertz MA, Wijmenga C; Genome of the Netherlands Consortium, Kayser M, Boomsma DI, Zöllner S, de Knijff P, Stoneking M.

Genome Res. 2016 Apr;26(4):417-26. doi: 10.1101/gr.203216.115. Epub 2016 Feb 25.

PMID:
26916109
13.

Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.

van der Kroef S, Noordam R, Deelen J, Akintola AA, Jansen SW, Postmus I, Wijsman CA, Beekman M, Mooijaart SP, Slagboom PE, van Heemst D.

PLoS One. 2016 Feb 25;11(2):e0149992. doi: 10.1371/journal.pone.0149992. eCollection 2016.

14.

DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age.

Waaijer ME, Croco E, Westendorp RG, Slagboom PE, Sedivy JM, Lorenzini A, Maier AB.

Aging (Albany NY). 2016 Jan;8(1):147-57.

15.

Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2.

van den Akker EB, Pitts SJ, Deelen J, Moed MH, Potluri S, van Rooij J, Suchiman HE, Lakenberg N, de Dijcker WJ, Uitterlinden AG, Kraaij R, Hofman A, de Craen AJ, Houwing-Duistermaat JJ, van Ommen GJ; Genome of The Netherlands Consortium, Cox DR, van Meurs JB, Beekman M, Reinders MJ, Slagboom PE.

Blood. 2016 Mar 17;127(11):1512-5. doi: 10.1182/blood-2015-12-685925. Epub 2016 Jan 29. No abstract available.

16.

Metabolic effects of a 13-weeks lifestyle intervention in older adults: The Growing Old Together Study.

van de Rest O, Schutte BA, Deelen J, Stassen SA, van den Akker EB, van Heemst D, Dibbets-Schneider P, van Dipten-van der Veen RA, Kelderman M, Hankemeier T, Mooijaart SP, van der Grond J, Houwing-Duistermaat JJ, Beekman M, Feskens EJ, Slagboom PE.

Aging (Albany NY). 2016 Jan;8(1):111-26.

17.

Non-response to (statin) therapy: the importance of distinguishing non-responders from non-adherers in pharmacogenetic studies.

Trompet S, Postmus I, Slagboom PE, Heijmans BT, Smit RA, Maier AB, Buckley BM, Sattar N, Stott DJ, Ford I, Westendorp RG, de Craen AJ, Jukema JW.

Eur J Clin Pharmacol. 2016 Apr;72(4):431-7. doi: 10.1007/s00228-015-1994-9. Epub 2015 Dec 19.

18.

Systematic discovery of complex insertions and deletions in human cancers.

Ye K, Wang J, Jayasinghe R, Lameijer EW, McMichael JF, Ning J, McLellan MD, Xie M, Cao S, Yellapantula V, Huang KL, Scott A, Foltz S, Niu B, Johnson KJ, Moed M, Slagboom PE, Chen F, Wendl MC, Ding L.

Nat Med. 2016 Jan;22(1):97-104. doi: 10.1038/nm.4002. Epub 2015 Dec 14.

PMID:
26657142
19.

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study.

van der Spoel E, Rozing MP, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, de Craen AJ, Westendorp RG, van Heemst D.

Aging (Albany NY). 2015 Nov;7(11):956-63.

20.

IL7R gene expression network associates with human healthy ageing.

Passtoors WM, van den Akker EB, Deelen J, Maier AB, van der Breggen R, Jansen R, Trompet S, van Heemst D, Derhovanessian E, Pawelec G, van Ommen GJ, Slagboom PE, Beekman M.

Immun Ageing. 2015 Nov 11;12:21. doi: 10.1186/s12979-015-0048-6. eCollection 2015.

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