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Invest Ophthalmol Vis Sci. 2013 Jul 8;54(7):4548-54. doi: 10.1167/iovs.13-11804.

Methods and reproducibility of grading optimized digital color fundus photographs in the Age-Related Eye Disease Study 2 (AREDS2 Report Number 2).

Collaborators (1006)

Chew EY, Ferris FL 3rd, SanGiovanni JP, Agrón E, Clemons T, Lindblad A, Lindblad R, Shah N, Sperduto R, McBee W, Gensler G, Harrington M, Henning A, Jones K, Thotapally K, Tull D, Watson V, Williams K, Gentry C, Kaufman F, Morrison C, Saverino E, Schenning S, Bonds D, Worrell B, Hsia J, Robinson J, Eaton C, Bertoni A, Blodi B, Danis RP, Davis M, Domalpally A, Glander K, Guilfoil G, Hubbard LD, Johnson K, Klein R, Nardi B, Neider M, Robinson N, Rosensteel E, Wabers H, Zhang G, Ruby AJ, Capone A Jr, Dass B, Drenser K, Garretson BR, Hassan TS, Trese M, Williams GA, Wolfe J, Bell T, Zajechowski M, Bezaire D, McIver F, Medina A, Pagett J, Smith SH, Swartz L, Treuter T, Antoszyk A, Brown J, Browning DJ, Holland W, Karow A, Stalford K, Price A, Ennis S, Fredenberg S, Herby J, Balasubramaniam U, Clark L, McClain D, McOwen M, Watson L, Klein M, Bailey ST, Hwang TJ, Lauer A, Stout J, McCollum P, Johnson M, Rice PB, Kim I, Loewenstein J, Miller J, Sobrin L, Young L, Sullivan J, Houlihan P, Merry L, Lane AM, Bator UL, Evans C, Brett S, Callahan C, Grillo M, Walsh D, Zimmerman KL, Fish GE, Anand R, Coors LE, Fuller DG, Spencer R, Wang RC, Duignan K, Arceneaux S, Aguado H, Hesse N, Mackens M, Swan B, Wong WT, Cukras C, Dalal M, Jacobs-El N, Meyerle C, Nicholson B, Wiley H, Shimel KH, Garced A, Oparah J, Short G, Temple A, Ayukawa B, Foster G, Hayes D, Koutsandreas D, Nashwinter R, Rowan J, Chew EY, Bono M, Cunningham D, Palmer M, Zetina A, Orth DH, Rezaei K, Civantos J, Hasan S, Packo K, Figliulo C, Stanberry P, Farmer T, Nelson K, Townsend-Patrick S, Rosenfeld P, Chen R, Doshi R, Dubovy S, Kim BT, Lowrance M, Moshfeghi A, Nahas Z, Schienbaum G, Vishak J, Weng C, Yehoshua Z, Rodriguez B, Rebimbas J, Gleichauf J, Kicak M, Mena J, Odem T, Sferza-Camp E, Disgdiertt A, Oramas J, Rams I, Thatcher S, Bressler SB, Bressler NM, Finkelstein D, Sherman SH, Solomon S, Ying HS, Denbow R, Phillips D, Radcliffe E, Belt J, Cain D, Emmert D, Herring M, McDonald J, Bergstrom CS, Cribbs B, Hendrick A, Johnson B, Laird P, Mehta S, Olsen T, Townsend J, Yan J, Yeh S, Curtis L, Brower J, Yi H, Dobbs JR, Jordan D, Elman MJ, Liss RA, Starr J, Belz J, Putzulo C, Coffey T, Davis A, Singletary P, Andreani GS, Cain T, Ketner D, Sotirakos P, Chandra S, Blodi BA, Altaweel MM, Danis RP, Gottlieb JL, Ip M, Klein R, Nork T, Stevens TS, Burke K, Olson S, Dietzman K, Soderling B, Somers G, Wealti A, Krolnik D, Peterson J, Reed S, Friberg T, Eller A, Gallagher D, Labriola L, Pokrifka M, Gedansky A, Anthony N, Grzybowski C, Matthews D, Murajda-Jumba S, Toro J, Fish GE, Callanan DG, Solley WA, Williams P, Lash S, Boleman B, Dock C, Fish GE, Shami M, Arrington B, Meeks A, Margherio AR, Raphaelian P, Markus D, Langdon J, Truax E, Lewis S, Terry B, Ruby AJ, Noffke A, Oh K, Sarrafizadeh R, Sneed S, Hammersley J, Neal S, Doran M, Jones N, Preston L, Jessick H, Marsh TT, Tolentino M, Berger A, Hamilton R, Misch D, Moon SJ, Sutherland D, Dilts V, Henderson S, Medina E, Trueman D, Holm L, Strickland J, Ie D, Lipkowitz JL, Shah KB, Geraghty S, Sannazzaro B, Harper M, Bayer K, Lansing MB, Fox LB, Lee R, Stallman JB, Jacobson M, Koh S, Lampert S, Miller J, Rivellese M, Sharma A, Stoltz RA, Vanderveldt S, Marcus L, Hendricks S, Hollman R, Betanzos G, Ellorin L, Fulbright S, McCormick D, Edwards PA, Hall J, Monk M, Gutkowski M, Mazurek M, Murphy J, Gusas K, Moffett C, Burley D, Chesney N, Kilgo K, Rusinek B, Stern B, Troszak T, Baker-Levingston R, Baker CW, Caldwell T, Walker T, Lambert LF, Martin T, Palmer MJ, Williams T, Novak MA, Coney J, Miller DG, Pendergast S, Singerman L, Zakov N, Zegarra H, DuBois K, Rath S, Revella L, Brink T, Drury K, Hogue L, Ilc M, Keller C, McNamara E, Tanner V, Cunningham T, DuBois J, Greanoff G, Nitzsche T, Smith-Brewer S, Isernhagen RD, Kitchens JW, Stone TW, Wood WJ, Holcomb D, Therrien V, Buck M, Van Arsdall J, Slade E, Schneiderman TE, Spinak DJ, Gaedke J, Brown HD, Helgren D, Pangelinan JG, Halperin L, Anagnoste S, Dhalla M, Rosenberg K, Taney B, Thompson W, Lopez J, Hamlin M, Lopez M, Mariano J, Quinchia E, Aramayo P, Veksler R, Lee M, Dreyer R, Handelman I, Ma C, Peters M, Hobbs S 3rd, Milliron A, Kopfer M, Connaughton M, Hoerner A, Logan R, Wohlsein HJ, Boyer D, Chu TG, Dayani P, Liao D, Novack RL, Rahhal FM, Roe R, Tabandeh H, Bayramyan J, Gasparyan T, Hoang C, Kurokouchi J, Lo TE, Ngo R, Nguyen MA, Peyton M, Yoon C, Sierra J, Zamboni A, Kessinger J, Protacio E, Smucker A, Rath P, Bergren R, Doft B, Liu J, Olsen K, Merlotti L, Ingram W, Marfisi K, Yeckel K, Schultz H, Fec A, McBroom K, Steinberg D, Levy M, Abrams J, Chen M, Torres W, Jelemensky P, Prybylski M, Raphael T, Appleby D, Rodman C, Sneath M, Rosa RH Jr, Hoelscher V, Castano A, Parker J, Hoskins J, Anderson N, Googe J Jr, McMillan TA, Miller J Jr, Perkins S, Oliver K, Beerbower J, Gilliland B, Hunt C, Jacobus M, Lince R, Morris C, Oelrich S, Whetstone J, Chan CK, Lin S, Walther K, Gonzales T, Myers L, Huff K, Brown DM, Chen E, Benz MS, Fish RH, Kim RY, Major J Jr, Wong TP, Wycoff C, Cone C, Gilaspia DG, Landaverde N, Smith R, Zamora D, Sneed V, Vela M, Kegley E, Greven C, Kurup S, Richards C, Slusher M, Everhart C, Fish J, Clark M, Miller D, Tyler M, Jumper J, Fu AD, Johnson RN, Lujan B, McDonald H, Rodriguez R, Ansari N, Joaquin J, Linares S, Lopez L, Sabio J, Grout S, Indermill C, Urias Y, Zimmerman R, Margulies L, Schmidt SJ, Meier JL, Hadley SL, Rosenthal W, Johnson B, Swafford L, Shields R, Varner R, Rosen R, Gentile R, Rivas M, Tai KW, Carrasquillo-Boyd W, Masini R, Stoller G, Carnevale K, LaRosa DM, Burger B, Conway T, Del Castillo C, Diaz J, Jones S, Mondoc N, Balfour C, Vitha CH, Lutz J, McGinley B, El Baba F, Lavorna AM, Jones R, Lewis J, Tenzler R, Salvas-Mladek M, Van Kesteren D, McLean WC Jr, Bridges WZ Jr, Stone C, Ammons D, Lamy M, Menzel A, Raymer LD, Campbell B, Hawkins L, Rickman L, Sherlin L, Price P, Sinyai A, Kingsley R, Bradford RH Jr, Leonard RE 2nd, Icks S, Bergman V, Ross B, Burris R, Butt A, Richmond R, Lyon A, Gill M, Jampol L, Mizra R, Rozenbajgier Z, Chapman J, Kaminski L, Degillio A, Simjanoski E, Heier J, Cho H, Cleary TS, Goldman D, Shah C, Topping T, Weber M, Wiegand T, Schindelheim J, Bankert J, Stone J, Nowak A, Chong S, Williams L, Bennett S, Donovan D, Graham M, Jones C, Fung A, Bayabo JK, Bosch R, Cruz E, Emerson A, Fleming A, Barsness D, Rodriguez J, Soboleva M, Scott IU, Bowie E, Neely KA, Quillen DA, Walter L, Bennett T, Strong J, Wells J 3rd, Clark L, Johnson D, Miller P, Taylor M, Swinford T, Spivey R, Banach M, Ho L, Lanning R, Pheasant TR, Prensky JG, Truong S, Teatsworth J, Dietrich M, Wasilus A, Miller A, Rakes M, Slagle T, Richards M, Schuessler P, Stover L, Beer P, Falk NS, Shannon MB, Olmeda J, Berdeen D, Fisher JF Jr, Folk J, Russell S, Taylor B, Hinz C, Walshire J, Stockman H, Critser B, Karakas S, Montague C, Verdick R, Gupta O, Maguire J, Brady C, DeCroos FC, Dollin M, Garg S, Gerstenblith A, Haller J, Ho AC, Hsu J, Kaiser R, Pitcher J, Regillo C, Shah R, Spirn M, Tasman W, Vander J, Senderowitsch N, Formoso M, Markun M, George C, Centinaro C, Grande L, Carey S, Liebenbaum E, Sadda S, Humayun M, Sierra R, Corona E, Padilla M, Nu M, Ramos S, Barnett C, Currie G, Gottlieb C, Garfinkel R, Berinstein D, Colyer M, Deegan W 3rd, Lai MM, Murphy R, Osman M, Rivers M, Sanders R, von Fricken MA, Oliver D, Kirshon J, Snowden TA, Blondo T, Cronise A, Denny V, Mendez K, Newgen J, Davis J, Flory M, Frantz R, Murphy B, Rauch S, Kim JE, Bachman J, Connor TB Jr, Han DP, Stepian K, Weinberg DV, Wirostko WJ, Packard K, Kaczanowski T, Williams V, Barwick V, Flanders J, Backes D, Beringer J, Keller K, Selchert K, Bernstein P, Teske M, Vitale A, Allman S, Carlstrom B, Wegner K, Haroldsen A, Harrison D, Fry C, Gilman J, Jenkins G, Morris P, Rauser M, Fan J, Suthar M, Santiago G, Halsey KR, Quesada C, Kiernan W, Knabb J, Lewis RA, Dorenbach C, Spencer S, Barnett D, Morales J, Fishburne BC, Gross JG, Magee MA, Flowers A, McDowell A, Price R, Huang S, Tang J, Wilker S, Hornsby C, Ferguson L, Krogstad K, Adamovsky R, Allchin P, Carlton K, Clow C, Sholtis K, Burke S, Harrod M, Hrvatin S, Pankhurst G, Sabates NR, Cassell M, Desai K, Poulose A, Sabates F, Chen Y, Gallimore G, Konior Y, Kim N, Uwaydat S, Troillett D, Aletter K, Abrams G, Puklin J, Tewari A, Milanovic C, Bailey M, Griffith D, McDonald D, Morehead K, Sadikovic Z, Schillace L, Silvis E, Joondeph B, Christmas N, Johnson D, Kimura A, Liu M, Petty S, Zilis J, Benitez J, Catlett CB, Fluegel E, Mowry S, Nguyen H, Reflow D, Houghton OM, Garg S, Landers MB, Meredith T, Barnhart S, Karmalkar M, Cantrell D, Esquejo-Leon RL, Manor L, Pope S, Stines D, Stokely A, Hainsworth D, Helming D, Eichelberger D, Leaton MP, Hamm C, Chaum E, Iannaccone A, Jennings B, Murray T, Mastellone J, Millay R, Kim B, Goddard T, Beaudette LJ, Changelian-Aitken N, Corrada F, Dubuque J, Iezzi R, Bakri SJ, Pulido JS, Vogen D, Nielsen R, Berg K, Burrington J, Howard S, Overend J, Krason Z, Lewison D, Link T, Blinder KJ, Engelbrecht NE, Grand M, Joseph DP, Shah GK, Smith B, Thomas M, Weeks R, Boyd L, Gabel D, Adelman R, Huang J, Kempton J, Parnes A, Dupont J, Perotti E, Donaldson V, Fong K, Ossorio P, Agarwal A, Sternberg P, Owings S, Adkins T, Lok E, Munn G, Skellie B, Bhagat N, Roy MS, Zarbin M, Fay C, Lazar M, Malpica B, Mikheyav T, Ulanski L 2nd, Lim J, Niec M, Johnson T, Ovando Y, Carroll C, Janowicz M, Schwartz S, Cupp D, Gorin M, Heilweil G, Hosseini H, Hubschman JP, Kreiger A, McCannel TY, Pan C, Sarraf D, Tsui I, Udoetek J, Voleti V, Hitchcock L, Ostrick R, Chun M, Kageyama J, Davila N, Lipka K, Shin C, Owsley C, Albert M Jr, Feist R, Mason J, Thomley M, Johnson A, Clark M, Emond T, Hamela J, Marsh A, Searcey K, Rookard K, He YG, Ufret-Vincenty RL, Molai M, Anderson W, Horna J, Letson A, Cebulla C, Chang S, Davidorf F, Salerno J, Sladoje L, Stetson C, Perry J, Savage S, Toth C, Jaffe G, Schuman S, Sarin N, Crowell J, Keaton T, Kelly M, Lutman B, Skelly M, Welch L, Morse L, Hunter A, Park SS, Wallace C, Dhillon E, Salvador M, Holderreed B, Chandra K, Kaur S, Redenbo E, Hom S, Cooney M, Barbazetto I, Klancnik JM Jr, Sorenson JA, Yannuzzi L, Scolaro M, Agresta E, Gonzalez N, Grover S, Chalam KV, Gupta S, Lyons C, Li W, Patel C, Carrion J, Ferreyra H, Rodriguez A, Molina I, Balea G, Emory P, Rico M, Siqueiros G, Brucker AJ, Dunaief J, Grunwald J, Kim B, Maguire AM, VanderBeek B, Drossner S, DuPont J, Salvo R, Berger J, Devine C, Nyberg B, Weeney L, DiLoreto D, Chung M, Davis V, MacDowell P, Gara GO, Castillo D, Czubinski A, Keim M, Hardy B, Hollar RG, Schueckler L, Lyon AT, Weinberg A, Shiloach M, Pelkofer N, Zhou Q, McPoland L, Apte R, Rao P, Pistorius S, Kambarian J, Adcock E, Gould S, Quinn M, Curtis R, Frost A, Meyer C, Rathert G.

Author information

  • 1Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53717, USA. rpdanis@wisc.edu

Abstract

PURPOSE:

To establish continuity with the grading procedures and outcomes from the historical data of the Age-Related Eye Disease Study (AREDS), color photographic imaging and evaluation procedures for the assessment of age-related macular degeneration (AMD) were modified for digital imaging in the AREDS2. The reproducibility of the grading of index AMD lesion components and for the AREDS severity scale was tested at the AREDS2 reading center.

METHODS:

Digital color stereoscopic fundus photographs from 4203 AREDS2 subjects collected at baseline and annual follow-up visits were optimized for tonal balance and graded according to a standard protocol slightly modified from AREDS. The reproducibility of digital grading of AREDS2 images was assessed by reproducibility exercises, temporal drift (regrading a subset of baseline annually, n = 88), and contemporaneous masked regrading (ongoing, monthly regrade on 5% of submissions, n = 1335 eyes).

RESULTS:

In AREDS2, 91% and 96% of images received replicate grades within two steps of the baseline value on the AREDS severity scale for temporal drift and contemporaneous assessment, respectively (weighted Kappa of 0.73 and 0.76). Historical data for temporal drift in replicate gradings on the AREDS film-based images were 88% within two steps (weighted Kappa = 0.88). There was no difference in AREDS2-AREDS concordance for temporal drift (exact P = 0.57).

CONCLUSIONS:

Digital color grading has nearly the same reproducibility as historical film grading. There is substantial agreement for testing the predictive utility of the AREDS severity scale in AREDS2 as a clinical trial outcome. (ClinicalTrials.gov number, NCT00345176.)

KEYWORDS:

AMD; color photographic imaging; reproducibility

PMID:
23620429
[PubMed - indexed for MEDLINE]
PMCID:
PMC3706107
Free PMC Article

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