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Results: 1 to 20 of 120

1.

Protein kinase A (PKA) phosphorylation of Shp2 inhibits its phosphatase activity and modulates ligand specificity.

Burmeister BT, Wang L, Gold MG, Skidgel RA, O'Bryan JP, Carnegie GK.

J Biol Chem. 2015 Mar 23. pii: jbc.M115.642983. [Epub ahead of print]

2.

UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy.

Wang L, Burmeister BT, Johnson KR, Baillie GS, Karginov AV, Skidgel RA, O'Bryan JP, Carnegie GK.

Cell Signal. 2015 May;27(5):908-22. doi: 10.1016/j.cellsig.2015.02.003. Epub 2015 Feb 12.

PMID:
25683917
3.

Downregulation of kinin B1 receptor function by B2 receptor heterodimerization and signaling.

Zhang X, Brovkovych V, Zhang Y, Tan F, Skidgel RA.

Cell Signal. 2015 Jan;27(1):90-103. doi: 10.1016/j.cellsig.2014.09.019. Epub 2014 Oct 5.

PMID:
25289859
4.

PR65A phosphorylation regulates PP2A complex signaling.

Kotlo K, Xing Y, Lather S, Grillon JM, Johnson K, Skidgel RA, Solaro RJ, Danziger RS.

PLoS One. 2014 Jan 21;9(1):e85000. doi: 10.1371/journal.pone.0085000. eCollection 2014.

5.

Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor.

Zhang X, Tan F, Skidgel RA.

J Biol Chem. 2013 Nov 15;288(46):33226-40. doi: 10.1074/jbc.M113.520791. Epub 2013 Oct 9.

6.

Endothelial nitric-oxide synthase activation generates an inducible nitric-oxide synthase-like output of nitric oxide in inflamed endothelium.

Lowry JL, Brovkovych V, Zhang Y, Skidgel RA.

J Biol Chem. 2013 Feb 8;288(6):4174-93. doi: 10.1074/jbc.M112.436022. Epub 2012 Dec 19.

7.

Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output.

Zhang X, Tan F, Brovkovych V, Zhang Y, Lowry JL, Skidgel RA.

Biol Chem. 2013 Mar;394(3):335-45. doi: 10.1515/hsz-2012-0290. Review.

8.

ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration.

Liu G, Place AT, Chen Z, Brovkovych VM, Vogel SM, Muller WA, Skidgel RA, Malik AB, Minshall RD.

Blood. 2012 Aug 30;120(9):1942-52. doi: 10.1182/blood-2011-12-397430. Epub 2012 Jul 17.

9.

Characterization of dual agonists for kinin B1 and B2 receptors and their biased activation of B2 receptors.

Zhang X, Lowry JL, Brovkovych V, Skidgel RA.

Cell Signal. 2012 Aug;24(8):1619-31. doi: 10.1016/j.cellsig.2012.04.002. Epub 2012 Apr 12.

10.

Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition.

Chen Z, Bakhshi FR, Shajahan AN, Sharma T, Mao M, Trane A, Bernatchez P, van Nieuw Amerongen GP, Bonini MG, Skidgel RA, Malik AB, Minshall RD.

Mol Biol Cell. 2012 Apr;23(7):1388-98. doi: 10.1091/mbc.E11-09-0811. Epub 2012 Feb 9.

11.

Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells.

Zhao Y, Jiang Z, Zhao T, Ye M, Hu C, Yin Z, Li H, Zhang Y, Diao Y, Li Y, Chen Y, Sun X, Fisk MB, Skidgel R, Holterman M, Prabhakar B, Mazzone T.

BMC Med. 2012 Jan 10;10:3. doi: 10.1186/1741-7015-10-3.

12.

Cross-talk between carboxypeptidase M and the kinin B1 receptor mediates a new mode of G protein-coupled receptor signaling.

Zhang X, Tan F, Brovkovych V, Zhang Y, Skidgel RA.

J Biol Chem. 2011 May 27;286(21):18547-61. doi: 10.1074/jbc.M110.214940. Epub 2011 Mar 31.

13.

Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model.

Zhao Y, Guo C, Hwang D, Lin B, Dingeldein M, Mihailescu D, Sam S, Sidhwani S, Zhang Y, Jain S, Skidgel RA, Prabhakar BS, Mazzone T, Holterman MJ.

Biochem Biophys Res Commun. 2010 Sep 3;399(4):629-36. doi: 10.1016/j.bbrc.2010.07.128. Epub 2010 Aug 4.

PMID:
20691153
14.

Beta-arrestin 2 is required for B1 receptor-dependent post-translational activation of inducible nitric oxide synthase.

Kuhr FK, Zhang Y, Brovkovych V, Skidgel RA.

FASEB J. 2010 Jul;24(7):2475-83. doi: 10.1096/fj.09-148783. Epub 2010 Mar 12.

15.

Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function.

Erdös EG, Tan F, Skidgel RA.

Hypertension. 2010 Feb;55(2):214-20. doi: 10.1161/HYPERTENSIONAHA.109.144600. Epub 2010 Jan 11. Review.

16.

Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptors.

Kuhr F, Lowry J, Zhang Y, Brovkovych V, Skidgel RA.

Neuropeptides. 2010 Apr;44(2):145-54. doi: 10.1016/j.npep.2009.12.004. Epub 2010 Jan 4. Review.

17.

A novel pathway for receptor-mediated post-translational activation of inducible nitric oxide synthase.

Brovkovych V, Zhang Y, Brovkovych S, Minshall RD, Skidgel RA.

J Cell Mol Med. 2011 Feb;15(2):258-69. doi: 10.1111/j.1582-4934.2009.00992.x.

18.

Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice.

Zhao Y, Lin B, Darflinger R, Zhang Y, Holterman MJ, Skidgel RA.

PLoS One. 2009;4(1):e4226. doi: 10.1371/journal.pone.0004226. Epub 2009 Jan 19.

19.

Signaling-mediated functional activation of inducible nitric-oxide synthase and its role in stimulating platelet activation.

Marjanovic JA, Stojanovic A, Brovkovych VM, Skidgel RA, Du X.

J Biol Chem. 2008 Oct 24;283(43):28827-34. doi: 10.1074/jbc.M801646200. Epub 2008 Aug 27.

20.

Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice.

Brovkovych V, Gao XP, Ong E, Brovkovych S, Brennan ML, Su X, Hazen SL, Malik AB, Skidgel RA.

Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L96-103. doi: 10.1152/ajplung.00450.2007. Epub 2008 Apr 18.

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