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Results: 17

1.

CHF5074 and LY450139 sub-acute treatments differently affect cortical extracellular glutamate levels in pre-plaque Tg2576 mice.

Beggiato S, Giuliani A, Sivilia S, Lorenzini L, Antonelli T, Imbimbo BP, Giardino L, Calzà L, Ferraro L.

Neuroscience. 2014 Apr 25;266:13-22. doi: 10.1016/j.neuroscience.2014.01.065. Epub 2014 Feb 12.

PMID:
24530449
2.

CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study.

Ross J, Sharma S, Winston J, Nunez M, Bottini G, Franceschi M, Scarpini E, Frigerio E, Fiorentini F, Fernandez M, Sivilia S, Giardino L, Calza L, Norris D, Cicirello H, Casula D, Imbimbo BP.

Curr Alzheimer Res. 2013 Sep;10(7):742-53.

PMID:
23968157
3.

CHF5074 Reduces Biomarkers of Neuroinflammation in Patients with Mild Cognitive Impairment: A 12-Week, Double-Blind, Placebo-Controlled Study.

Ross J, Sharma S, Winston J, Nunez M, Bottini G, Franceschi M, Scarpini E, Frigerio E, Fiorentini F, Fernandez M, Sivilia S, Giardin L, Calzà L, Norris D, Cicirello H, Casula D, Imbimbo B.

Curr Alzheimer Res. 2013 Aug 2. [Epub ahead of print]

PMID:
23952019
4.

From the multifactorial nature of Alzheimer`s disease to multitarget therapy: the contribution of the translational approach.

Calzà L, Baldassarro VA, Giuliani A, Lorenzini L, Fernandez M, Mangano C, Sivilia S, Alessandri M, Gusciglio M, Torricella R, Giardino L.

Curr Top Med Chem. 2013;13(15):1843-52. Review.

PMID:
23931439
5.

Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.

Sivilia S, Lorenzini L, Giuliani A, Gusciglio M, Fernandez M, Baldassarro VA, Mangano C, Ferraro L, Pietrini V, Baroc MF, Viscomi AR, Ottonello S, Villetti G, Imbimbo BP, Calzà L, Giardino L.

BMC Neurosci. 2013 Apr 5;14:44. doi: 10.1186/1471-2202-14-44.

6.

Pharmacokinetics and pharmacodynamics of CHF5074 after short-term administration in healthy subjects.

Imbimbo BP, Frigerio E, Breda M, Fiorentini F, Fernandez M, Sivilia S, Giardino L, Calzà L, Norris D, Casula D, Shenouda M.

Alzheimer Dis Assoc Disord. 2013 Jul-Sep;27(3):278-86. doi: 10.1097/WAD.0b013e3182622ace.

PMID:
22922591
7.

Gender effect on neurodegeneration and myelin markers in an animal model for multiple sclerosis.

Massella A, D'Intino G, Fernández M, Sivilia S, Lorenzini L, Giatti S, Melcangi RC, Calzà L, Giardino L.

BMC Neurosci. 2012 Jan 24;13:12. doi: 10.1186/1471-2202-13-12.

8.

Functional and molecular evidence of myelin- and neuroprotection by thyroid hormone administration in experimental allergic encephalomyelitis.

Dell'Acqua ML, Lorenzini L, D'Intino G, Sivilia S, Pasqualetti P, Panetta V, Paradisi M, Filippi MM, Baiguera C, Pizzi M, Giardino L, Rossini PM, Calzà L.

Neuropathol Appl Neurobiol. 2012 Aug;38(5):454-70. doi: 10.1111/j.1365-2990.2011.01228.x.

PMID:
22007951
9.

The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice.

Balducci C, Mehdawy B, Mare L, Giuliani A, Lorenzini L, Sivilia S, Giardino L, Calzà L, Lanzillotta A, Sarnico I, Pizzi M, Usiello A, Viscomi AR, Ottonello S, Villetti G, Imbimbo BP, Nisticò G, Forloni G, Nisticò R.

J Alzheimers Dis. 2011;24(4):799-816. doi: 10.3233/JAD-2011-101839.

PMID:
21321397
10.

A single prenatal exposure to the endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin alters developmental myelination and remyelination potential in the rat brain.

Fernández M, Paradisi M, D'Intino G, Del Vecchio G, Sivilia S, Giardino L, Calzà L.

J Neurochem. 2010 Nov;115(4):897-909. doi: 10.1111/j.1471-4159.2010.06974.x. Epub 2010 Sep 28.

PMID:
20807317
11.

CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease.

Imbimbo BP, Giardino L, Sivilia S, Giuliani A, Gusciglio M, Pietrini V, Del Giudice E, D'Arrigo A, Leon A, Villetti G, Calzà L.

J Alzheimers Dis. 2010;20(1):159-73. doi: 10.3233/JAD-2010-1366.

PMID:
20164581
12.

Gabapentin treatment improves motor coordination in a mice model of progressive ataxia.

Massella A, Gusciglio M, D'Intino G, Sivilia S, Ferraro L, Calzà L, Giardino L.

Brain Res. 2009 Dec 8;1301:135-42. doi: 10.1016/j.brainres.2009.09.004. Epub 2009 Sep 9.

PMID:
19747469
13.

Intravitreal NGF administration counteracts retina degeneration after permanent carotid artery occlusion in rat.

Sivilia S, Giuliani A, Fernández M, Turba ME, Forni M, Massella A, De Sordi N, Giardino L, Calzà L.

BMC Neurosci. 2009 May 27;10:52. doi: 10.1186/1471-2202-10-52.

14.

Skin homeostasis during inflammation: a role for nerve growth factor.

Sivilia S, Paradisi M, D'Intino G, Fernandez M, Pirondi S, Lorenzini L, Calzà L.

Histol Histopathol. 2008 Jan;23(1):1-10.

PMID:
17952852
15.

Age-dependent impairment of hippocampal neurogenesis in chronic cerebral hypoperfusion.

Sivilia S, Giuliani A, Del Vecchio G, Giardino L, Calzà L.

Neuropathol Appl Neurobiol. 2008 Feb;34(1):52-61. Epub 2007 Oct 11.

PMID:
17931356
16.

A molecular study of hippocampus in dogs with convulsion during canine distemper virus encephalitis.

D'Intino G, Vaccari F, Sivilia S, Scagliarini A, Gandini G, Giardino L, Calzà L.

Brain Res. 2006 Jul 7;1098(1):186-95. Epub 2006 Jun 9.

PMID:
16765333
17.

Thyroid hormone and remyelination in adult central nervous system: a lesson from an inflammatory-demyelinating disease.

Calzà L, Fernandez M, Giuliani A, D'Intino G, Pirondi S, Sivilia S, Paradisi M, Desordi N, Giardino L.

Brain Res Brain Res Rev. 2005 Apr;48(2):339-46. Epub 2005 Jan 26. Review.

PMID:
15850672
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