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Results: 1 to 20 of 476


BRCA1-like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential.

Severson TM, Peeters J, Majewski I, Michaut M, Bosma A, Schouten PC, Chin SF, Pereira B, Goldgraben MA, Bismeijer T, Kluin RJ, Muris JJ, Jirström K, Kerkhoven RM, Wessels L, Caldas C, Bernards R, Simon IM, Linn S.

Mol Oncol. 2015 May 7. pii: S1574-7891(15)00099-X. doi: 10.1016/j.molonc.2015.04.011. [Epub ahead of print]


Combination of Pharmacophore Matching, 2D Similarity Search, and In Vitro Biological Assays in the Selection of Potential 5-HT6 Antagonists from Large Commercial Repositories.

Dobi K, Flachner B, Pukáncsik M, Máthé E, Bognár M, Szaszkó M, Magyar C, Hajdú I, Lőrincz Z, Simon I, Fülöp F, Cseh S, Dormán G.

Chem Biol Drug Des. 2015 Mar 30. doi: 10.1111/cbdd.12563. [Epub ahead of print]


The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain.

Laptenko O, Shiff I, Freed-Pastor W, Zupnick A, Mattia M, Freulich E, Shamir I, Kadouri N, Kahan T, Manfredi J, Simon I, Prives C.

Mol Cell. 2015 Mar 19;57(6):1034-46. doi: 10.1016/j.molcel.2015.02.015.


Decreased expression of ABAT and STC2 hallmarks ER-positive inflammatory breast cancer and endocrine therapy resistance in advanced disease.

Jansen MP, Sas L, Sieuwerts AM, Van Cauwenberghe C, Ramirez-Ardila D, Look M, Ruigrok-Ritstier K, Finetti P, Bertucci F, Timmermans MM, van Deurzen CH, Martens JW, Simon I, Roepman P, Linn SC, van Dam P, Kok M, Lardon F, Vermeulen PB, Foekens JA, Dirix L, Berns EM, Van Laere S.

Mol Oncol. 2015 Jun;9(6):1218-33. doi: 10.1016/j.molonc.2015.02.006. Epub 2015 Mar 4.


Lineage correlations of single cell division time as a probe of cell-cycle dynamics.

Sandler O, Mizrahi SP, Weiss N, Agam O, Simon I, Balaban NQ.

Nature. 2015 Mar 26;519(7544):468-71. doi: 10.1038/nature14318. Epub 2015 Mar 11.


[Contribution of clinical biology in the etiological exploration and follow-up of urolithiasis].

Cotton F, Wolff F, Simon I, Idrissi M, Tielemans C, Vanden Bossche M, Roumeguère T, Pozdzik A.

Rev Med Brux. 2014 Sep;35(4):243-9. French.


Genomic classifier ColoPrint predicts recurrence in stage II colorectal cancer patients more accurately than clinical factors.

Kopetz S, Tabernero J, Rosenberg R, Jiang ZQ, Moreno V, Bachleitner-Hofmann T, Lanza G, Stork-Sloots L, Maru D, Simon I, Capellà G, Salazar R.

Oncologist. 2015 Feb;20(2):127-33. doi: 10.1634/theoncologist.2014-0325. Epub 2015 Jan 5.


Prediction and analysis of intrinsically disordered proteins.

Punta M, Simon I, Dosztányi Z.

Methods Mol Biol. 2015;1261:35-59. doi: 10.1007/978-1-4939-2230-7_3.


Circulating osteoprotegerin is increased in the metabolic syndrome and associates with subclinical atherosclerosis and coronary arterial calcification.

Pérez de Ciriza C, Moreno M, Restituto P, Bastarrika G, Simón I, Colina I, Varo N.

Clin Biochem. 2014 Dec;47(18):272-8. doi: 10.1016/j.clinbiochem.2014.09.004. Epub 2014 Sep 16.


A word of caution about biological inference - Revisiting cysteine covalent state predictions.

Tüdős E, Mészáros B, Fiser A, Simon I.

FEBS Open Bio. 2014 Mar 12;4:310-4. doi: 10.1016/j.fob.2014.03.003. eCollection 2014.


Combination of 2D/3D ligand-based similarity search in rapid virtual screening from multimillion compound repositories. Selection and biological evaluation of potential PDE4 and PDE5 inhibitors.

Dobi K, Hajdú I, Flachner B, Fabó G, Szaszkó M, Bognár M, Magyar C, Simon I, Szisz D, Lőrincz Z, Cseh S, Dormán G.

Molecules. 2014 May 28;19(6):7008-39. doi: 10.3390/molecules19067008.


MammaPrint molecular diagnostics on formalin-fixed, paraffin-embedded tissue.

Sapino A, Roepman P, Linn SC, Snel MH, Delahaye LJ, van den Akker J, Glas AM, Simon IM, Barth N, de Snoo FA, van 't Veer LJ, Molinaro L, Berns EM, Wesseling J, Riley LB, Anderson D, Nguyen B, Cox CE.

J Mol Diagn. 2014 Mar;16(2):190-7. doi: 10.1016/j.jmoldx.2013.10.008. Epub 2013 Dec 28.


Hallmarks of aromatase inhibitor drug resistance revealed by epigenetic profiling in breast cancer.

Jansen MP, Knijnenburg T, Reijm EA, Simon I, Kerkhoven R, Droog M, Velds A, van Laere S, Dirix L, Alexi X, Foekens JA, Wessels L, Linn SC, Berns EM, Zwart W.

Cancer Res. 2013 Nov 15;73(22):6632-41. doi: 10.1158/0008-5472.CAN-13-0704.


TGF-β: an emerging player in drug resistance.

Brunen D, Willems SM, Kellner U, Midgley R, Simon I, Bernards R.

Cell Cycle. 2013 Sep 15;12(18):2960-8. doi: 10.4161/cc.26034. Epub 2013 Aug 12.


Integrative analysis of methylome and transcriptome reveals the importance of unmethylated CpGs in non-CpG island gene activation.

Marx A, Kahan T, Simon I.

Biomed Res Int. 2013;2013:785731. doi: 10.1155/2013/785731. Epub 2013 Jul 10.


DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype.

De Vriendt V, De Roock W, Di Narzo AF, Tian S, Biesmans B, Jacobs B, Budinska E, Sagaert X, Rossi S, D'Ario G, Delorenzi M, Simon I, Vecchione L, Tejpar S.

Biomarkers. 2013 Sep;18(6):516-24. doi: 10.3109/1354750X.2013.819038. Epub 2013 Jul 22.


Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition.

Roepman P, Schlicker A, Tabernero J, Majewski I, Tian S, Moreno V, Snel MH, Chresta CM, Rosenberg R, Nitsche U, Macarulla T, Capella G, Salazar R, Orphanides G, Wessels LF, Bernards R, Simon IM.

Int J Cancer. 2014 Feb 1;134(3):552-62. doi: 10.1002/ijc.28387. Epub 2013 Sep 13.


Series of concentration-induced phase transitions in cholesterol/phosphatidylcholine mixtures.

Sugár IP, Simon I, Chong PL.

Biophys J. 2013 Jun 4;104(11):2448-55. doi: 10.1016/j.bpj.2013.04.048.


Independent validation of a prognostic genomic signature (ColoPrint) for patients with stage II colon cancer.

Maak M, Simon I, Nitsche U, Roepman P, Snel M, Glas AM, Schuster T, Keller G, Zeestraten E, Goossens I, Janssen KP, Friess H, Rosenberg R.

Ann Surg. 2013 Jun;257(6):1053-8. doi: 10.1097/SLA.0b013e31827c1180.


Zinc-α2-glycoprotein is unrelated to gestational diabetes: anthropometric and metabolic determinants in pregnant women and their offspring.

Näf S, Escote X, Yañez RE, Ballesteros M, Simón I, Gil P, Megia A, Vendrell J.

PLoS One. 2012;7(12):e47601. doi: 10.1371/journal.pone.0047601. Epub 2012 Dec 18.

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