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Results: 1 to 20 of 103

1.

Implicating exudate macrophages and Ly-6C(high) monocytes in CCR2-dependent lung fibrosis following gene-targeted alveolar injury.

Osterholzer JJ, Olszewski MA, Murdock BJ, Chen GH, Erb-Downward JR, Subbotina N, Browning K, Lin Y, Morey RE, Dayrit JK, Horowitz JC, Simon RH, Sisson TH.

J Immunol. 2013 Apr 1;190(7):3447-57. doi: 10.4049/jimmunol.1200604. Epub 2013 Mar 6.

PMID:
23467934
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury.

Osterholzer JJ, Christensen PJ, Lama V, Horowitz JC, Hattori N, Subbotina N, Cunningham A, Lin Y, Murdock BJ, Morey RE, Olszewski MA, Lawrence DA, Simon RH, Sisson TH.

J Pathol. 2012 Oct;228(2):170-80. doi: 10.1002/path.3992. Epub 2012 Jun 6.

PMID:
22262246
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Plasmin overcomes resistance to prostaglandin E2 in fibrotic lung fibroblasts by reorganizing protein kinase A signaling.

Okunishi K, Sisson TH, Huang SK, Hogaboam CM, Simon RH, Peters-Golden M.

J Biol Chem. 2011 Sep 16;286(37):32231-43. doi: 10.1074/jbc.M111.235606. Epub 2011 Jul 27.

PMID:
21795691
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice.

Courey AJ, Horowitz JC, Kim KK, Koh TJ, Novak ML, Subbotina N, Warnock M, Xue B, Cunningham AK, Lin Y, Goldklang MP, Simon RH, Lawrence DA, Sisson TH.

Blood. 2011 Aug 25;118(8):2313-21. doi: 10.1182/blood-2010-12-324574. Epub 2011 Jul 6.

PMID:
21734232
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice.

Bauman KA, Wettlaufer SH, Okunishi K, Vannella KM, Stoolman JS, Huang SK, Courey AJ, White ES, Hogaboam CM, Simon RH, Toews GB, Sisson TH, Moore BB, Peters-Golden M.

J Clin Invest. 2010 Jun;120(6):1950-60. doi: 10.1172/JCI38369. Epub 2010 May 24.

PMID:
20501949
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis.

Sisson TH, Mendez M, Choi K, Subbotina N, Courey A, Cunningham A, Dave A, Engelhardt JF, Liu X, White ES, Thannickal VJ, Moore BB, Christensen PJ, Simon RH.

Am J Respir Crit Care Med. 2010 Feb 1;181(3):254-63. doi: 10.1164/rccm.200810-1615OC. Epub 2009 Oct 22.

PMID:
19850947
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Urokinase-type plasminogen activator increases hepatocyte growth factor activity required for skeletal muscle regeneration.

Sisson TH, Nguyen MH, Yu B, Novak ML, Simon RH, Koh TJ.

Blood. 2009 Dec 3;114(24):5052-61. doi: 10.1182/blood-2008-12-196212. Epub 2009 Oct 7.

PMID:
19812386
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Genetic modifiers of liver disease in cystic fibrosis.

Bartlett JR, Friedman KJ, Ling SC, Pace RG, Bell SC, Bourke B, Castaldo G, Castellani C, Cipolli M, Colombo C, Colombo JL, Debray D, Fernandez A, Lacaille F, Macek M Jr, Rowland M, Salvatore F, Taylor CJ, Wainwright C, Wilschanski M, Zemkov√° D, Hannah WB, Phillips MJ, Corey M, Zielenski J, Dorfman R, Wang Y, Zou F, Silverman LM, Drumm ML, Wright FA, Lange EM, Durie PR, Knowles MR; Gene Modifier Study Group.

JAMA. 2009 Sep 9;302(10):1076-83. doi: 10.1001/jama.2009.1295.

PMID:
19738092
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model.

Kuramoto E, Nishiuma T, Kobayashi K, Yamamoto M, Kono Y, Funada Y, Kotani Y, Sisson TH, Simon RH, Nishimura Y.

Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L337-46. doi: 10.1152/ajplung.90434.2008. Epub 2008 Dec 19.

PMID:
19098125
[PubMed - indexed for MEDLINE]
Free Article
10.

The plasminogen activation system in lung disease.

Sisson TH, Simon RH.

Curr Drug Targets. 2007 Sep;8(9):1016-29. Review.

PMID:
17896953
[PubMed - indexed for MEDLINE]
11.

Plasminogen activation induced pericellular fibronectin proteolysis promotes fibroblast apoptosis.

Horowitz JC, Rogers DS, Simon RH, Sisson TH, Thannickal VJ.

Am J Respir Cell Mol Biol. 2008 Jan;38(1):78-87. Epub 2007 Jul 26.

PMID:
17656680
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Plasminogen-mediated activation and release of hepatocyte growth factor from extracellular matrix.

Matsuoka H, Sisson TH, Nishiuma T, Simon RH.

Am J Respir Cell Mol Biol. 2006 Dec;35(6):705-13. Epub 2006 Jul 13.

PMID:
16840775
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Expression of the reverse tetracycline-transactivator gene causes emphysema-like changes in mice.

Sisson TH, Hansen JM, Shah M, Hanson KE, Du M, Ling T, Simon RH, Christensen PJ.

Am J Respir Cell Mol Biol. 2006 May;34(5):552-60. Epub 2006 Jan 13.

PMID:
16415250
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Clinical implications of macrolide therapy in chronic sinopulmonary diseases.

Martinez FJ, Simon RH.

Curr Pharm Des. 2004;10(25):3095-110. Review.

PMID:
15544500
[PubMed - indexed for MEDLINE]
15.

Cell specific control of coagulation and fibrinolysis within the lung.

Sisson TH, Simon RH.

Thromb Haemost. 2004 Sep;92(3):435-7. Review. No abstract available.

PMID:
15351836
[PubMed - indexed for MEDLINE]
16.

Plasminogen activator inhibitor-1 impairs alveolar epithelial repair by binding to vitronectin.

Lazar MH, Christensen PJ, Du M, Yu B, Subbotina NM, Hanson KE, Hansen JM, White ES, Simon RH, Sisson TH.

Am J Respir Cell Mol Biol. 2004 Dec;31(6):672-8. Epub 2004 Aug 12.

PMID:
15308506
[PubMed - indexed for MEDLINE]
17.

Localization of plasminogen activator activity within normal and injured lungs by in situ zymography.

Nishiuma T, Sisson TH, Subbotina N, Simon RH.

Am J Respir Cell Mol Biol. 2004 Nov;31(5):552-8. Epub 2004 Jul 29.

PMID:
15284078
[PubMed - indexed for MEDLINE]
18.

The plasminogen activation system reduces fibrosis in the lung by a hepatocyte growth factor-dependent mechanism.

Hattori N, Mizuno S, Yoshida Y, Chin K, Mishima M, Sisson TH, Simon RH, Nakamura T, Miyake M.

Am J Pathol. 2004 Mar;164(3):1091-8.

PMID:
14982862
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Cystic fibrosis adult care: consensus conference report.

Yankaskas JR, Marshall BC, Sufian B, Simon RH, Rodman D.

Chest. 2004 Jan;125(1 Suppl):1S-39S. Review. No abstract available.

PMID:
14734689
[PubMed - indexed for MEDLINE]
20.

Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1.

Chuang-Tsai S, Sisson TH, Hattori N, Tsai CG, Subbotina NM, Hanson KE, Simon RH.

Am J Pathol. 2003 Aug;163(2):445-52.

PMID:
12875966
[PubMed - indexed for MEDLINE]
Free PMC Article

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