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Results: 1 to 20 of 209

1.

RFC1 80G>A is a genetic determinant of methotrexate efficacy in rheumatoid arthritis: a human genome epidemiologic review and meta-analysis of observational studies.

Kung TN, Dennis J, Ma Y, Xie G, Bykerk V, Pope J, Thorne C, Keystone E, Siminovitch KA, Gagnon F.

Arthritis Rheumatol. 2014 May;66(5):1111-20. doi: 10.1002/art.38331.

PMID:
24782176
[PubMed - in process]
2.

Genetics in PBC: What Do the "Risk Genes" Teach Us?

Hirschfield GM, Siminovitch KA.

Clin Rev Allergy Immunol. 2014 Apr 18. [Epub ahead of print]

PMID:
24744192
[PubMed - as supplied by publisher]
3.

Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene.

Okada Y, Diogo D, Greenberg JD, Mouassess F, Achkar WA, Fulton RS, Denny JC, Gupta N, Mirel D, Gabriel S, Li G, Kremer JM, Pappas DA, Carroll RJ, Eyler AE, Trynka G, Stahl EA, Cui J, Saxena R, Coenen MJ, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Barton A, Canhão H, Fonseca JE, de Vries N, Tak PP, Moreland LW, Bridges SL Jr, Miceli-Richard C, Choi HK, Kamatani Y, Galan P, Lathrop M, Raj T, De Jager PL, Raychaudhuri S, Worthington J, Padyukov L, Klareskog L, Siminovitch KA, Gregersen PK, Mardis ER, Arayssi T, Kazkaz LA, Plenge RM.

PLoS One. 2014 Feb 10;9(2):e87645. doi: 10.1371/journal.pone.0087645. eCollection 2014.

PMID:
24520335
[PubMed - in process]
Free PMC Article
4.

Reply.

Farrer LA, Sherva R, Merkel PA, Siminovitch KA.

Arthritis Rheumatol. 2014 May;66(5):1401. doi: 10.1002/art.38366. No abstract available.

PMID:
24469994
[PubMed - in process]
5.

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Bridges SL Jr, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M; RACI consortium; GARNET consortium, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM.

Nature. 2014 Feb 20;506(7488):376-81. doi: 10.1038/nature12873. Epub 2013 Dec 25.

PMID:
24390342
[PubMed - indexed for MEDLINE]
6.

RFC-1 80G>A is a genetic determinant of methotrexate efficacy in Rheumatoid Arthritis: A HuGE review and meta-analysis of observational studies.

Kung TN, Dennis J, Ma Y, Xie G, Bykerk V, Pope J, Thorne C, Keystone E, Siminovitch KA, Gagnon F.

Arthritis Rheum. 2013 Dec 24. doi: 10.1002/art.38331. [Epub ahead of print]

PMID:
24375097
[PubMed - as supplied by publisher]
7.

Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARγ.

Xu E, Forest MP, Schwab M, Avramoglu RK, St-Amand E, Caron AZ, Bellmann K, Shum M, Voisin G, Paquet M, Montoudis A, Lévy E, Siminovitch KA, Neel BG, Beauchemin N, Marette A.

Hepatology. 2014 May;59(5):1803-15. doi: 10.1002/hep.26957. Epub 2014 Apr 1.

PMID:
24327268
[PubMed - indexed for MEDLINE]
8.

Mammalian diaphanous-related formin 1 regulates GSK3β-dependent microtubule dynamics required for T cell migratory polarization.

Dong B, Zhang SS, Gao W, Su H, Chen J, Jin F, Bhargava A, Chen X, Jorgensen L, Alberts AS, Zhang J, Siminovitch KA.

PLoS One. 2013 Nov 18;8(11):e80500. doi: 10.1371/journal.pone.0080500. eCollection 2013.

PMID:
24260404
[PubMed - in process]
Free PMC Article
9.

Deep basal inferoseptal crypts occur more commonly in patients with hypertrophic cardiomyopathy due to disease-causing myofilament mutations.

Deva DP, Williams LK, Care M, Siminovitch KA, Moshonov H, Wintersperger BJ, Rakowski H, Crean AM.

Radiology. 2013 Oct;269(1):68-76. doi: 10.1148/radiol.13122344. Epub 2013 Jun 14.

PMID:
23771913
[PubMed - indexed for MEDLINE]
10.

Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.

Xie G, Roshandel D, Sherva R, Monach PA, Lu EY, Kung T, Carrington K, Zhang SS, Pulit SL, Ripke S, Carette S, Dellaripa PF, Edberg JC, Hoffman GS, Khalidi N, Langford CA, Mahr AD, St Clair EW, Seo P, Specks U, Spiera RF, Stone JH, Ytterberg SR, Raychaudhuri S, de Bakker PI, Farrer LA, Amos CI, Merkel PA, Siminovitch KA.

Arthritis Rheum. 2013 Sep;65(9):2457-68. doi: 10.1002/art.38036.

PMID:
23740775
[PubMed - indexed for MEDLINE]
11.

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway.

Li G, Diogo D, Wu D, Spoonamore J, Dancik V, Franke L, Kurreeman F, Rossin EJ, Duclos G, Hartland C, Zhou X, Li K, Liu J, De Jager PL, Siminovitch KA, Zhernakova A, Raychaudhuri S, Bowes J, Eyre S, Padyukov L, Gregersen PK, Worthington J; Rheumatoid Arthritis Consortium International (RACI), Gupta N, Clemons PA, Stahl E, Tolliday N, Plenge RM.

PLoS Genet. 2013 May;9(5):e1003487. doi: 10.1371/journal.pgen.1003487. Epub 2013 May 16.

PMID:
23696745
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Pathway-based analysis of primary biliary cirrhosis genome-wide association studies.

Kar SP, Seldin MF, Chen W, Lu E, Hirschfield GM, Invernizzi P, Heathcote J, Cusi D; Italian PBC Genetics Study Group, Gershwin ME, Siminovitch KA, Amos CI.

Genes Immun. 2013 Apr;14(3):179-86. doi: 10.1038/gene.2013.1. Epub 2013 Feb 7.

PMID:
23392275
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis.

Diogo D, Kurreeman F, Stahl EA, Liao KP, Gupta N, Greenberg JD, Rivas MA, Hickey B, Flannick J, Thomson B, Guiducci C, Ripke S, Adzhubey I, Barton A, Kremer JM, Alfredsson L; Consortium of Rheumatology Researchers of North America; Rheumatoid Arthritis Consortium International, Sunyaev S, Martin J, Zhernakova A, Bowes J, Eyre S, Siminovitch KA, Gregersen PK, Worthington J, Klareskog L, Padyukov L, Raychaudhuri S, Plenge RM.

Am J Hum Genet. 2013 Jan 10;92(1):15-27. doi: 10.1016/j.ajhg.2012.11.012. Epub 2012 Dec 20.

PMID:
23261300
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Identification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis.

Xie G, Lu Y, Sun Y, Zhang SS, Keystone EC, Gregersen PK, Plenge RM, Amos CI, Siminovitch KA.

Ann Rheum Dis. 2013 Jul;72(7):1249-54. doi: 10.1136/annrheumdis-2012-202076. Epub 2012 Dec 6.

PMID:
23223422
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.

Wang Q, Siminovitch KA, Downey GP, McCulloch CA.

Biochem J. 2013 Feb 1;449(3):771-82. doi: 10.1042/BJ20121170.

PMID:
23145787
[PubMed - indexed for MEDLINE]
Free Article
16.

Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants.

Juran BD, Hirschfield GM, Invernizzi P, Atkinson EJ, Li Y, Xie G, Kosoy R, Ransom M, Sun Y, Bianchi I, Schlicht EM, Lleo A, Coltescu C, Bernuzzi F, Podda M, Lammert C, Shigeta R, Chan LL, Balschun T, Marconi M, Cusi D, Heathcote EJ, Mason AL, Myers RP, Milkiewicz P, Odin JA, Luketic VA, Bacon BR, Bodenheimer HC Jr, Liakina V, Vincent C, Levy C, Franke A, Gregersen PK, Bossa F, Gershwin ME, deAndrade M, Amos CI; Italian PBC Genetics Study Group, Lazaridis KN, Seldin MF, Siminovitch KA.

Hum Mol Genet. 2012 Dec 1;21(23):5209-21. doi: 10.1093/hmg/dds359. Epub 2012 Aug 29.

PMID:
22936693
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Vitamin D receptor polymorphism rs2228570 (Fok1) is associated with rheumatoid arthritis in North American natives.

Hitchon CA, Sun Y, Robinson DB, Peschken CA, Bernstein CN, Siminovitch KA, El-Gabalawy HS.

J Rheumatol. 2012 Sep;39(9):1792-7. doi: 10.3899/jrheum.120387. Epub 2012 Aug 1.

PMID:
22859341
[PubMed - indexed for MEDLINE]
18.

Hepatocyte-specific Ptpn6 deletion protects from obesity-linked hepatic insulin resistance.

Xu E, Charbonneau A, Rolland Y, Bellmann K, Pao L, Siminovitch KA, Neel BG, Beauchemin N, Marette A.

Diabetes. 2012 Aug;61(8):1949-58. doi: 10.2337/db11-1502. Epub 2012 Jun 14.

PMID:
22698917
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis.

Invernizzi P, Ransom M, Raychaudhuri S, Kosoy R, Lleo A, Shigeta R, Franke A, Bossa F, Amos CI, Gregersen PK, Siminovitch KA, Cusi D, de Bakker PI, Podda M, Gershwin ME, Seldin MF; Italian PBC Genetics Study Group.

Genes Immun. 2012 Sep;13(6):461-8. doi: 10.1038/gene.2012.17. Epub 2012 May 10.

PMID:
22573116
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis.

Chung SA, Xie G, Roshandel D, Sherva R, Edberg JC, Kravitz M, Dellaripa PF, Hoffman GS, Mahr AD, Seo P, Specks U, Spiera RF, St Clair EW, Stone JH, Plenge RM, Siminovitch KA, Merkel PA, Monach PA.

Arthritis Rheum. 2012 Oct;64(10):3463-71. doi: 10.1002/art.34496.

PMID:
22508400
[PubMed - indexed for MEDLINE]
Free PMC Article

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