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A randomized, crossover, placebo-controlled clinical trial to assess the sensitivity of the CRCDS Mini-Sim to the next-day residual effects of zopiclone.

Simen AA, Gargano C, Cha JH, Drexel M, Bautmans A, Heirman I, Laethem T, Hochadel T, Gheyle L, Bleys K, Beals C, Stoch A, Kay GG, Struyk A.

Ther Adv Drug Saf. 2015 Jun;6(3):86-97. doi: 10.1177/2042098615579314.


Efavirenz modulation of sleep spindles and sleep spectral profile.

Simen AA, Ma J, Svetnik V, Mayleben D, Maynard J, Roth A, Mixson L, Mogg R, Shera D, George L, Mast TC, Beals C, Stoch A, Struyk A, Shire N, Fraser I.

J Sleep Res. 2015 Feb;24(1):66-73. doi: 10.1111/jsr.12196. Epub 2014 Aug 12.


cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex.

Carlyle BC, Nairn AC, Wang M, Yang Y, Jin LE, Simen AA, Ramos BP, Bordner KA, Craft GE, Davies P, Pletikos M, Ε estan N, Arnsten AF, Paspalas CD.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):5036-41. doi: 10.1073/pnas.1322360111. Epub 2014 Mar 18.


Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels.

El-Hassar L, Simen AA, Duque A, Patel KD, Kaczmarek LK, Arnsten AF, Yeckel MF.

Biol Psychiatry. 2014 Sep 15;76(6):476-85. doi: 10.1016/j.biopsych.2013.12.019. Epub 2014 Jan 20.


Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction.

Gamo NJ, Duque A, Paspalas CD, Kata A, Fine R, Boven L, Bryan C, Lo T, Anighoro K, Bermudez L, Peng K, Annor A, Raja A, Mansson E, Taylor SR, Patel K, Simen AA, Arnsten AF.

Transl Psychiatry. 2013 Dec 3;3:e328. doi: 10.1038/tp.2013.104.


Maternal separation with early weaning: a rodent model providing novel insights into neglect associated developmental deficits.

Carlyle BC, Duque A, Kitchen RR, Bordner KA, Coman D, Doolittle E, Papademetris X, Hyder F, Taylor JR, Simen AA.

Dev Psychopathol. 2012 Nov;24(4):1401-16. doi: 10.1017/S095457941200079X.


Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence.

Zhang H, Herman AI, Kranzler HR, Anton RF, Simen AA, Gelernter J.

J Hum Genet. 2012 Oct;57(10):670-5. doi: 10.1038/jhg.2012.98. Epub 2012 Aug 23.


Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression.

McIntosh AM, Simen AA, Evans KL, Hall J, Macintyre DJ, Blackwood D, Morris AD, Smith BH, Dominiczak A, Porteous D, Deary HI, Thomson PA.

Front Genet. 2012 Jul 2;3:116. doi: 10.3389/fgene.2012.00116. eCollection 2012.


Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects.

Duric V, Banasr M, Stockmeier CA, Simen AA, Newton SS, Overholser JC, Jurjus GJ, Dieter L, Duman RS.

Int J Neuropsychopharmacol. 2013 Feb;16(1):69-82. doi: 10.1017/S1461145712000016. Epub 2012 Feb 17.


Relative impact of key sources of systematic noise in Affymetrix and Illumina gene-expression microarray experiments.

Kitchen RR, Sabine VS, Simen AA, Dixon JM, Bartlett JM, Sims AH.

BMC Genomics. 2011 Dec 1;12:589. doi: 10.1186/1471-2164-12-589.


Under-treatment of depression in older persons.

Barry LC, Abou JJ, Simen AA, Gill TM.

J Affect Disord. 2012 Feb;136(3):789-96. doi: 10.1016/j.jad.2011.09.038. Epub 2011 Oct 26.


Neuroanatomical changes in a mouse model of early life neglect.

Duque A, Coman D, Carlyle BC, Bordner KA, George ED, Papademetris X, Hyder F, Simen AA.

Brain Struct Funct. 2012 Apr;217(2):459-72. doi: 10.1007/s00429-011-0350-9. Epub 2011 Oct 8.


Functional genomic and proteomic analysis reveals disruption of myelin-related genes and translation in a mouse model of early life neglect.

Bordner KA, George ED, Carlyle BC, Duque A, Kitchen RR, Lam TT, Colangelo CM, Stone KL, Abbott TB, Mane SM, Nairn AC, Simen AA.

Front Psychiatry. 2011 Apr 25;2:18. doi: 10.3389/fpsyt.2011.00018. eCollection 2011.


Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder.

Kelmendi B, Holsbach-Beltrame M, McIntosh AM, Hilt L, George ED, Kitchen RR, Carlyle BC, Pittenger C, Coric V, Nolen-Hoeksema S, Sanacora G, Simen AA.

Neurosci Lett. 2011 Jun 8;496(3):195-9. doi: 10.1016/j.neulet.2011.04.026. Epub 2011 Apr 20.


Cognitive dysfunction with aging and the role of inflammation.

Simen AA, Bordner KA, Martin MP, Moy LA, Barry LC.

Ther Adv Chronic Dis. 2011 May;2(3):175-95. doi: 10.1177/2040622311399145.


Parallel declines in cognition, motivation, and locomotion in aging mice: association with immune gene upregulation in the medial prefrontal cortex.

Bordner KA, Kitchen RR, Carlyle B, George ED, Mahajan MC, Mane SM, Taylor JR, Simen AA.

Exp Gerontol. 2011 Aug;46(8):643-59. doi: 10.1016/j.exger.2011.03.003. Epub 2011 Mar 29.


A negative regulator of MAP kinase causes depressive behavior.

Duric V, Banasr M, Licznerski P, Schmidt HD, Stockmeier CA, Simen AA, Newton SS, Duman RS.

Nat Med. 2010 Nov;16(11):1328-32. doi: 10.1038/nm.2219. Epub 2010 Oct 17.


Maternal separation with early weaning: a novel mouse model of early life neglect.

George ED, Bordner KA, Elwafi HM, Simen AA.

BMC Neurosci. 2010 Sep 29;11:123. doi: 10.1186/1471-2202-11-123.


Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region.

Zhang H, Gelernter J, Gruen JR, Kranzler HR, Herman AI, Simen AA.

J Hum Genet. 2010 May;55(5):278-84. doi: 10.1038/jhg.2010.22. Epub 2010 Mar 19.


Adolescent cannabis use, psychosis and catechol-O-methyltransferase genotype in African Americans and Caucasians.

Kantrowitz JT, Nolan KA, Sen S, Simen AA, Lachman HM, Bowers MB Jr.

Psychiatr Q. 2009 Dec;80(4):213-8. doi: 10.1007/s11126-009-9108-4.

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