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A recombinant two-module form of human properdin is an inhibitor of the complement alternative pathway.

Kouser L, Abdul-Aziz M, Tsolaki AG, Singhal D, Schwaeble WJ, Urban BC, Khan HA, Sim RB, Kishore U.

Mol Immunol. 2016 Apr 6;73:76-87. doi: 10.1016/j.molimm.2016.03.005. [Epub ahead of print]


Complement factor H in its alternative identity as adrenomedullin-binding protein 1.

Sim RB, Ferluga J, Al-Rashidi H, Abbow H, Schwaeble W, Kishore U.

Mol Immunol. 2015 Nov;68(1):45-8. doi: 10.1016/j.molimm.2015.06.006. Review.


Innate immune humoral factors, C1q and factor H, with differential pattern recognition properties, alter macrophage response to carbon nanotubes.

Pondman KM, Pednekar L, Paudyal B, Tsolaki AG, Kouser L, Khan HA, Shamji MH, Ten Haken B, Stenbeck G, Sim RB, Kishore U.

Nanomedicine. 2015 Nov;11(8):2109-18. doi: 10.1016/j.nano.2015.06.009. Epub 2015 Jul 11.


European Union funded project on the development of a whole complement deficiency screening ELISA-A story of success and an exceptional manager: Mohamed R. Daha.

Würzner R, Tedesco F, Garred P, Mollnes TE, Truedsson L, Turner MW, Sommarin Y, Wieslander J, Sim RB.

Mol Immunol. 2015 Nov;68(1):63-6. doi: 10.1016/j.molimm.2015.05.003. Epub 2015 May 23. Review.


Low-dose recombinant properdin provides substantial protection against Streptococcus pneumoniae and Neisseria meningitidis infection.

Ali YM, Hayat A, Saeed BM, Haleem KS, Alshamrani S, Kenawy HI, Ferreira VP, Saggu G, Buchberger A, Lachmann PJ, Sim RB, Goundis D, Andrew PW, Lynch NJ, Schwaeble WJ.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5301-6. doi: 10.1073/pnas.1401011111. Epub 2014 Mar 24.


A potential anti-coagulant role of complement factor H.

Ferluga J, Kishore U, Sim RB.

Mol Immunol. 2014 Jun;59(2):188-93. doi: 10.1016/j.molimm.2014.02.012. Epub 2014 Mar 13.


Complement activation by carbon nanotubes and its influence on the phagocytosis and cytokine response by macrophages.

Pondman KM, Sobik M, Nayak A, Tsolaki AG, Jäkel A, Flahaut E, Hampel S, Ten Haken B, Sim RB, Kishore U.

Nanomedicine. 2014 Aug;10(6):1287-99. doi: 10.1016/j.nano.2014.02.010. Epub 2014 Mar 6.


Human L-ficolin, a recognition molecule of the lectin activation pathway of complement, activates complement by binding to pneumolysin, the major toxin of Streptococcus pneumoniae.

Ali YM, Kenawy HI, Muhammad A, Sim RB, Andrew PW, Schwaeble WJ.

PLoS One. 2013 Dec 12;8(12):e82583. doi: 10.1371/journal.pone.0082583. eCollection 2013.


Purification, quantification, and functional analysis of Complement Factor H.

Yu BB, Moffatt BE, Fedorova M, Villiers CG, Arnold JN, Du E, Swinkels A, Li MC, Ryan A, Sim RB.

Methods Mol Biol. 2014;1100:207-23. doi: 10.1007/978-1-62703-724-2_17.


Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3.

Bajic G, Yatime L, Sim RB, Vorup-Jensen T, Andersen GR.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16426-31. doi: 10.1073/pnas.1311261110. Epub 2013 Sep 24.


Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration.

Ansari M, McKeigue PM, Skerka C, Hayward C, Rudan I, Vitart V, Polasek O, Armbrecht AM, Yates JR, Vatavuk Z, Bencic G, Kolcic I, Oostra BA, Van Duijn CM, Campbell S, Stanton CM, Huffman J, Shu X, Khan JC, Shahid H, Harding SP, Bishop PN, Deary IJ, Moore AT, Dhillon B, Rudan P, Zipfel PF, Sim RB, Hastie ND, Campbell H, Wright AF.

Hum Mol Genet. 2013 Dec 1;22(23):4857-69. doi: 10.1093/hmg/ddt336. Epub 2013 Jul 19.


Ligands and receptors of lung surfactant proteins SP-A and SP-D.

Jakel A, Qaseem AS, Kishore U, Sim RB.

Front Biosci (Landmark Ed). 2013 Jun 1;18:1129-40. Review.


Properdin and factor h: opposing players on the alternative complement pathway "see-saw".

Kouser L, Abdul-Aziz M, Nayak A, Stover CM, Sim RB, Kishore U.

Front Immunol. 2013 Apr 23;4:93. doi: 10.3389/fimmu.2013.00093. eCollection 2013.


The complement system of the goat: haemolytic assays and isolation of major proteins.

Moreno-Indias I, Dodds AW, Argüello A, Castro N, Sim RB.

BMC Vet Res. 2012 Jun 26;8:91. doi: 10.1186/1746-6148-8-91.


Effect of functionalization of carbon nanotubes with psychosine on complement activation and protein adsorption.

Rybak-Smith MJ, Tripisciano C, Borowiak-Palen E, Lamprecht C, Sim RB.

J Biomed Nanotechnol. 2011 Dec;7(6):830-9.


Human complement Factor H modulates C1q-mediated phagocytosis of apoptotic cells.

Kang YH, Urban BC, Sim RB, Kishore U.

Immunobiology. 2012 Apr;217(4):455-64. doi: 10.1016/j.imbio.2011.10.008. Epub 2011 Oct 23.


Chemical labelling of active serum thioester proteins for quantification.

Holm L, Ackland GL, Edwards MR, Breckenridge RA, Sim RB, Offer J.

Immunobiology. 2012 Feb;217(2):256-64. doi: 10.1016/j.imbio.2011.07.021. Epub 2011 Jul 23.


Factor H as a regulator of the classical pathway activation.

Kishore U, Sim RB.

Immunobiology. 2012 Feb;217(2):162-8. doi: 10.1016/j.imbio.2011.07.024. Epub 2011 Jul 23.


Structures of the rat complement regulator CrrY.

Roversi P, Johnson S, Caesar JJ, McLean F, Leath KJ, Tsiftsoglou SA, Morgan BP, Harris CL, Sim RB, Lea SM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):739-43. doi: 10.1107/S1744309111016551. Epub 2011 Jun 23.


Structural basis for complement factor I control and its disease-associated sequence polymorphisms.

Roversi P, Johnson S, Caesar JJ, McLean F, Leath KJ, Tsiftsoglou SA, Morgan BP, Harris CL, Sim RB, Lea SM.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12839-44. doi: 10.1073/pnas.1102167108. Epub 2011 Jul 18.

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