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Molecular pathways and targets in prostate cancer.

Shtivelman E, Beer TM, Evans CP.

Oncotarget. 2014 Sep 15;5(17):7217-59. Review.


Pathways and therapeutic targets in melanoma.

Shtivelman E, Davies MQ, Hwu P, Yang J, Lotem M, Oren M, Flaherty KT, Fisher DE.

Oncotarget. 2014 Apr 15;5(7):1701-52. Review.


Molecular pathways and therapeutic targets in lung cancer.

Shtivelman E, Hensing T, Simon GR, Dennis PA, Otterson GA, Bueno R, Salgia R.

Oncotarget. 2014 Mar 30;5(6):1392-433. Review.


Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS.

Chen V, Staub RE, Fong S, Tagliaferri M, Cohen I, Shtivelman E.

PLoS One. 2012;7(2):e30300. doi: 10.1371/journal.pone.0030300. Epub 2012 Feb 3.


Identification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle.

Chen V, Staub RE, Baggett S, Chimmani R, Tagliaferri M, Cohen I, Shtivelman E.

PLoS One. 2012;7(1):e30107. doi: 10.1371/journal.pone.0030107. Epub 2012 Jan 17.


Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: a combined proteomic and metabolomic study.

Klawitter J, Klawitter J, Gurshtein J, Corby K, Fong S, Tagliaferri M, Quattrochi L, Cohen I, Shtivelman E, Christians U.

Int J Cancer. 2011 Dec 15;129(12):2945-57. doi: 10.1002/ijc.25965. Epub 2011 Apr 20.


CC3/TIP30 regulates metabolic adaptation of tumor cells to glucose limitation.

Chen V, Shtivelman E.

Cell Cycle. 2010 Dec 15;9(24):4941-53. Epub 2010 Dec 15.


Estrogen receptor β causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2.

Paruthiyil S, Cvoro A, Tagliaferri M, Cohen I, Shtivelman E, Leitman DC.

Breast Cancer Res Treat. 2011 Oct;129(3):777-84. doi: 10.1007/s10549-010-1273-5. Epub 2010 Dec 1.


Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression.

DeLisser H, Liu Y, Desprez PY, Thor A, Briasouli P, Handumrongkul C, Wilfong J, Yount G, Nosrati M, Fong S, Shtivelman E, Fehrenbach M, Cao G, Moore DH, Nayak S, Liggitt D, Kashani-Sabet M, Debs R.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18616-21. doi: 10.1073/pnas.1004654107. Epub 2010 Oct 6. Erratum in: Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3821. Nyack, Shruti [corrected to Nayak, Shruti].


CC3/TIP30 affects DNA damage repair.

Fong S, King F, Shtivelman E.

BMC Cell Biol. 2010 Apr 7;11:23. doi: 10.1186/1471-2121-11-23.


A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer.

Perez AT, Arun B, Tripathy D, Tagliaferri MA, Shaw HS, Kimmick GG, Cohen I, Shtivelman E, Caygill KA, Grady D, Schactman M, Shapiro CL.

Breast Cancer Res Treat. 2010 Feb;120(1):111-8. doi: 10.1007/s10549-009-0678-5.


Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid.

Chu R, Zhao X, Griffin C, Staub RE, Shoemaker M, Climent J, Leitman D, Cohen I, Shtivelman E, Fong S.

Int J Cancer. 2010 Sep 1;127(5):1209-19. doi: 10.1002/ijc.25116.


Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress.

King FW, Fong S, Griffin C, Shoemaker M, Staub R, Zhang YL, Cohen I, Shtivelman E.

PLoS One. 2009 Sep 30;4(9):e7283. doi: 10.1371/journal.pone.0007283.


Molecular mechanisms underlying selective cytotoxic activity of BZL101, an extract of Scutellaria barbata, towards breast cancer cells.

Fong S, Shoemaker M, Cadaoas J, Lo A, Liao W, Tagliaferri M, Cohen I, Shtivelman E.

Cancer Biol Ther. 2008 Apr;7(4):577-86. Epub 2008 Jan 7.


Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer.

Rugo H, Shtivelman E, Perez A, Vogel C, Franco S, Tan Chiu E, Melisko M, Tagliaferri M, Cohen I, Shoemaker M, Tran Z, Tripathy D.

Breast Cancer Res Treat. 2007 Sep;105(1):17-28. Epub 2006 Nov 17.


Inhibition of nuclear import by the proapoptotic protein CC3.

King FW, Shtivelman E.

Mol Cell Biol. 2004 Aug;24(16):7091-101.


AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation.

Stiff T, Shtivelman E, Jeggo P, Kysela B.

DNA Repair (Amst). 2004 Mar 4;3(3):245-56.


Inhibition of Chk1 by activated PKB/Akt.

King FW, Skeen J, Hay N, Shtivelman E.

Cell Cycle. 2004 May;3(5):634-7. Epub 2004 May 31.

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