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Results: 1 to 20 of 52

1.

3-Bromopyruvate: targets and outcomes.

Shoshan MC.

J Bioenerg Biomembr. 2012 Feb;44(1):7-15. doi: 10.1007/s10863-012-9419-2. Review.

PMID:
22298255
[PubMed - indexed for MEDLINE]
2.

Potentiation of anti-cancer treatment by modulators of energy metabolism.

Shoshan MC.

Curr Pharm Biotechnol. 2013 Mar 1;14(3):313-30. Review.

PMID:
22201600
[PubMed - indexed for MEDLINE]
3.

Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model.

Fayad W, Brnjic S, Berglind D, Blixt S, Shoshan MC, Berndtsson M, Olofsson MH, Linder S.

Int J Cancer. 2009 Nov 15;125(10):2450-5. doi: 10.1002/ijc.24627.

PMID:
19670329
[PubMed - indexed for MEDLINE]
4.

Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation.

Kutuk O, Arisan ED, Tezil T, Shoshan MC, Basaga H.

Carcinogenesis. 2009 Sep;30(9):1517-27. doi: 10.1093/carcin/bgp165. Epub 2009 Jul 3.

PMID:
19578044
[PubMed - indexed for MEDLINE]
Free Article
5.

Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis.

Berndtsson M, Hernlund E, Shoshan MC, Linder S.

J Chem Biol. 2009 Jun;2(2):81-7. doi: 10.1007/s12154-009-0017-7. Epub 2009 Mar 31.

PMID:
19568785
[PubMed]
Free PMC Article
6.

3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.

Ihrlund LS, Hernlund E, Khan O, Shoshan MC.

Mol Oncol. 2008 Jun;2(1):94-101. doi: 10.1016/j.molonc.2008.01.003. Epub 2008 Jan 13.

PMID:
19383331
[PubMed - indexed for MEDLINE]
Free Article
7.

Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells.

Pettersson HM, Pietras A, Munksgaard Persson M, Karlsson J, Johansson L, Shoshan MC, Påhlman S.

Mol Cancer Ther. 2009 Jan;8(1):160-70. doi: 10.1158/1535-7163.MCT-08-0595.

PMID:
19139125
[PubMed - indexed for MEDLINE]
Free Article
8.

Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II.

Olofsson MH, Havelka AM, Brnjic S, Shoshan MC, Linder S.

BMC Chem Biol. 2008 Aug 1;8:2. doi: 10.1186/1472-6769-8-2.

PMID:
18673549
[PubMed]
Free PMC Article
9.

Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir.

Hernlund E, Ihrlund LS, Khan O, Ates YO, Linder S, Panaretakis T, Shoshan MC.

Int J Cancer. 2008 Jul 15;123(2):476-83. doi: 10.1002/ijc.23525.

PMID:
18452174
[PubMed - indexed for MEDLINE]
10.

Target specificity and off-target effects as determinants of cancer drug efficacy.

Shoshan MC, Linder S.

Expert Opin Drug Metab Toxicol. 2008 Mar;4(3):273-80. doi: 10.1517/17425255.4.3.273 . Review.

PMID:
18363542
[PubMed - indexed for MEDLINE]
11.

Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect?

Havelka AM, Berndtsson M, Olofsson MH, Shoshan MC, Linder S.

Mini Rev Med Chem. 2007 Oct;7(10):1035-9. Review.

PMID:
17979806
[PubMed - indexed for MEDLINE]
12.

Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy.

Olofsson MH, Ueno T, Pan Y, Xu R, Cai F, van der Kuip H, Muerdter TE, Sonnenberg M, Aulitzky WE, Schwarz S, Andersson E, Shoshan MC, Havelka AM, Toi M, Linder S.

Clin Cancer Res. 2007 Jun 1;13(11):3198-206.

PMID:
17545523
[PubMed - indexed for MEDLINE]
Free Article
13.

Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor.

Linder S, Shoshan MC, Gupta RS.

Cancer Res. 2007 Mar 15;67(6):2899; author reply 2899-900. No abstract available. Erratum in: Cancer Res. 2007 Jul 1;67(13):6529.

PMID:
17363615
[PubMed - indexed for MEDLINE]
Free Article
14.

Sense and sensibility: the use of cell death biomarker assays in high-throughput anticancer drug screening and monitoring treatment responses.

Shoshan MC, Havelka AP, Neumann F, Linder S.

Expert Opin Drug Discov. 2006 Nov;1(6):585-94. doi: 10.1517/17460441.1.6.585.

PMID:
23506068
[PubMed]
15.

Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA.

Berndtsson M, Hägg M, Panaretakis T, Havelka AM, Shoshan MC, Linder S.

Int J Cancer. 2007 Jan 1;120(1):175-80.

PMID:
17044026
[PubMed - indexed for MEDLINE]
16.

Is translational research compatible with preclinical publication strategies?

Linder S, Shoshan MC.

Radiat Oncol. 2006 Mar 24;1:4.

PMID:
16722592
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1.

Ihrlund LS, Hernlund E, Viktorsson K, Panaretakis T, Barna G, Sabapathy K, Linder S, Shoshan MC.

Exp Cell Res. 2006 May 15;312(9):1581-9. Epub 2006 Mar 9.

PMID:
16529740
[PubMed - indexed for MEDLINE]
18.

Lysosomes and endoplasmic reticulum: targets for improved, selective anticancer therapy.

Linder S, Shoshan MC.

Drug Resist Updat. 2005 Aug;8(4):199-204. Epub 2005 Aug 1. Review.

PMID:
16055370
[PubMed - indexed for MEDLINE]
19.

Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.

Panaretakis T, Laane E, Pokrovskaja K, Björklund AC, Moustakas A, Zhivotovsky B, Heyman M, Shoshan MC, Grandér D.

Mol Biol Cell. 2005 Aug;16(8):3821-31. Epub 2005 May 25.

PMID:
15917298
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis.

Erdal H, Berndtsson M, Castro J, Brunk U, Shoshan MC, Linder S.

Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):192-7. Epub 2004 Dec 23.

PMID:
15618392
[PubMed - indexed for MEDLINE]
Free PMC Article

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