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Results: 1 to 20 of 115

1.

Clozapine directly increases insulin and glucagon secretion from islets: Implications for impairment of glucose tolerance.

Smith GC, Zhang ZY, Mulvey T, Petersen N, Lach S, Xiu P, Phillips A, Han W, Wang MW, Shepherd PR.

Schizophr Res. 2014 Jun 3. pii: S0920-9964(14)00230-8. doi: 10.1016/j.schres.2014.05.003. [Epub ahead of print]

PMID:
24906220
[PubMed - as supplied by publisher]
2.

The activation of the Akt/PKB signalling pathway in the brains of clozapine-exposed rats is linked to hyperinsulinemia and not a direct drug effect.

Smith GC, McEwen H, Steinberg JD, Shepherd PR.

Psychopharmacology (Berl). 2014 May 7. [Epub ahead of print]

PMID:
24800899
[PubMed - as supplied by publisher]
3.

Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma.

Höland K, Boller D, Hagel C, Dolski S, Treszl A, Pardo OE, Cwiek P, Salm F, Leni Z, Shepherd PR, Styp-Rekowska B, Djonov V, von Bueren AO, Frei K, Arcaro A.

PLoS One. 2014 Apr 9;9(4):e94132. doi: 10.1371/journal.pone.0094132. eCollection 2014.

PMID:
24718026
[PubMed - in process]
Free PMC Article
4.

Structure, function and inhibition of the phosphoinositide 3-kinase p110α enzyme.

Flanagan JU, Shepherd PR.

Biochem Soc Trans. 2014 Feb;42(1):120-4. doi: 10.1042/BST20130255.

PMID:
24450638
[PubMed - in process]
5.

Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation.

Liu J, Xu A, Lam KS, Wong NS, Chen J, Shepherd PR, Wang Y.

Oncotarget. 2013 Oct;4(10):1804-18.

PMID:
24113220
[PubMed - in process]
Free PMC Article
6.

Hypothalamic WNT signalling is impaired during obesity and reinstated by leptin treatment in male mice.

Benzler J, Andrews ZB, Pracht C, Stöhr S, Shepherd PR, Grattan DR, Tups A.

Endocrinology. 2013 Dec;154(12):4737-45. doi: 10.1210/en.2013-1746. Epub 2013 Oct 8.

PMID:
24105484
[PubMed - indexed for MEDLINE]
7.

Enzyme activity effects of N-terminal His-tag attached to catalytic sub-unit of phosphoinositide-3-kinase.

Dickson JM, Lee WJ, Shepherd PR, Buchanan CM.

Biosci Rep. 2013 Nov 5;33(6). pii: e00079. doi: 10.1042/BSR20130075.

PMID:
23968392
[PubMed - in process]
Free PMC Article
8.

Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity.

Buchanan CM, Dickson JM, Lee WJ, Guthridge MA, Kendall JD, Shepherd PR.

PLoS One. 2013 Aug 1;8(8):e71337. doi: 10.1371/journal.pone.0071337. Print 2013.

PMID:
23936502
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.

Liu Y, Lai YC, Hill EV, Tyteca D, Carpentier S, Ingvaldsen A, Vertommen D, Lantier L, Foretz M, Dequiedt F, Courtoy PJ, Erneux C, Viollet B, Shepherd PR, Tavaré JM, Jensen J, Rider MH.

Biochem J. 2013 Oct 15;455(2):195-206. doi: 10.1042/BJ20130644.

PMID:
23905686
[PubMed - indexed for MEDLINE]
10.

Extended treatment with selective phosphatidylinositol 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength.

Smith GC, Ong WK, Costa JL, Watson M, Cornish J, Grey A, Gamble GD, Dickinson M, Leung S, Rewcastle GW, Han W, Shepherd PR.

FEBS J. 2013 Nov;280(21):5337-49. doi: 10.1111/febs.12428. Epub 2013 Aug 12.

PMID:
23837532
[PubMed - indexed for MEDLINE]
11.

Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).

Rewcastle GW, Gamage SA, Flanagan JU, Kendall JD, Denny WA, Baguley BC, Buchanan CM, Chao M, Kestell P, Kolekar S, Lee WJ, Lill CL, Malik A, Singh R, Jamieson SM, Shepherd PR.

Eur J Med Chem. 2013 Jun;64:137-47. doi: 10.1016/j.ejmech.2013.03.038. Epub 2013 Apr 6.

PMID:
23644197
[PubMed - indexed for MEDLINE]
12.

Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival.

Thomas D, Powell JA, Green BD, Barry EF, Ma Y, Woodcock J, Fitter S, Zannettino AC, Pitson SM, Hughes TP, Lopez AF, Shepherd PR, Wei AH, Ekert PG, Guthridge MA.

PLoS Biol. 2013;11(3):e1001515. doi: 10.1371/journal.pbio.1001515. Epub 2013 Mar 19.

PMID:
23526884
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM.

Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264.

PMID:
23211529
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Identification of a pathway by which glucose regulates β-catenin signalling via the cAMP/protein kinase A pathway in β-cell models.

Cognard E, Dargaville CG, Hay DL, Shepherd PR.

Biochem J. 2013 Feb 1;449(3):803-11. doi: 10.1042/BJ20121454.

PMID:
23198873
[PubMed - indexed for MEDLINE]
Free Article
15.

Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism.

Benzler J, Ganjam GK, Krüger M, Pinkenburg O, Kutschke M, Stöhr S, Steger J, Koch CE, Ölkrug R, Schwartz MW, Shepherd PR, Grattan DR, Tups A.

Biochem J. 2012 Oct 1;447(1):175-84. doi: 10.1042/BJ20120834.

PMID:
22849606
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Beta-testing of PI3-kinase inhibitors: is beta better?

Shepherd PR, Denny WA.

Cancer Discov. 2012 May;2(5):393-4. doi: 10.1158/2159-8290.CD-12-0122.

PMID:
22588874
[PubMed - indexed for MEDLINE]
17.

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.

Zheng Z, Amran SI, Zhu J, Schmidt-Kittler O, Kinzler KW, Vogelstein B, Shepherd PR, Thompson PE, Jennings IG.

Biochem J. 2012 Jun 15;444(3):529-35. doi: 10.1042/BJ20120499.

PMID:
22502592
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Concurrent resistance and aerobic exercise stimulates both myofibrillar and mitochondrial protein synthesis in sedentary middle-aged men.

Donges CE, Burd NA, Duffield R, Smith GC, West DW, Short MJ, Mackenzie R, Plank LD, Shepherd PR, Phillips SM, Edge JA.

J Appl Physiol (1985). 2012 Jun;112(12):1992-2001. doi: 10.1152/japplphysiol.00166.2012. Epub 2012 Apr 5.

PMID:
22492939
[PubMed - indexed for MEDLINE]
Free Article
19.

Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines.

Kim JE, Stones C, Joseph WR, Leung E, Finlay GJ, Shelling AN, Phillips WA, Shepherd PR, Baguley BC.

BMC Cancer. 2012 Apr 4;12:141. doi: 10.1186/1471-2407-12-141.

PMID:
22475322
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade.

Lancaster GI, Skiba B, Yang C, Nicholls HT, Langley KG, Chan MH, Bruce CR, Rewcastle GW, Shepherd PR, Karin M, Febbraio MA.

Biochem J. 2012 Mar 15;442(3):723-32. doi: 10.1042/BJ20112037. Erratum in: Biochem J. 2013 May 15;452(1):171.

PMID:
22364283
[PubMed - indexed for MEDLINE]
Free Article

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