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Items: 1 to 20 of 84

1.

Thrombolysis by chemically modified coagulation factor Xa.

Pryzdial EL, Meixner SC, Talbot K, Eltringham-Smith LJ, Baylis JR, Lee FM, Kastrup CJ, Sheffield WP.

J Thromb Haemost. 2016 Jun 30. doi: 10.1111/jth.13402. [Epub ahead of print]

PMID:
27359348
2.

Blood-Borne Pathogens: A Canadian Blood Services Centre for Innovation Symposium.

Walsh GM, Shih AW, Solh Z, Golder M, Schubert P, Fearon M, Sheffield WP.

Transfus Med Rev. 2016 Apr;30(2):53-68. doi: 10.1016/j.tmrv.2016.02.003. Epub 2016 Feb 23. Review.

PMID:
26962008
3.

CD44 Antibody Inhibition of Macrophage Phagocytosis Targets Fcγ Receptor- and Complement Receptor 3-Dependent Mechanisms.

Amash A, Wang L, Wang Y, Bhakta V, Fairn GD, Hou M, Peng J, Sheffield WP, Lazarus AH.

J Immunol. 2016 Apr 15;196(8):3331-40. doi: 10.4049/jimmunol.1502198. Epub 2016 Mar 4.

PMID:
26944929
4.

The M358R variant of α(1)-proteinase inhibitor inhibits coagulation factor VIIa.

Sheffield WP, Bhakta V.

Biochem Biophys Res Commun. 2016 Feb 12;470(3):710-3. doi: 10.1016/j.bbrc.2016.01.069. Epub 2016 Jan 13.

PMID:
26797521
5.

Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin.

Qadri SM, Donkor DA, Bhakta V, Eltringham-Smith LJ, Dwivedi DJ, Moore JC, Pepler L, Ivetic N, Nazi I, Fox-Robichaud AE, Liaw PC, Sheffield WP.

J Cell Mol Med. 2016 Apr;20(4):710-20. doi: 10.1111/jcmm.12778. Epub 2016 Jan 19.

6.

Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2.

Lang E, Bissinger R, Fajol A, Salker MS, Singh Y, Zelenak C, Ghashghaeinia M, Gu S, Jilani K, Lupescu A, Reyskens KM, Ackermann TF, Föller M, Schleicher E, Sheffield WP, Arthur JS, Lang F, Qadri SM.

Sci Rep. 2015 Nov 27;5:17316. doi: 10.1038/srep17316.

7.

Monovalent Fc receptor blockade by an anti-Fcγ receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity.

Yu X, Menard M, Prechl J, Bhakta V, Sheffield WP, Lazarus AH.

Blood. 2016 Jan 7;127(1):132-8. doi: 10.1182/blood-2015-08-664656. Epub 2015 Oct 23.

PMID:
26500340
8.

Stability of coagulation protein activities in single units or pools of cryoprecipitate during storage at 20-24°C for up to 24 h.

Sheffield WP, Bhakta V, Jenkins C.

Vox Sang. 2016 Jan;110(1):12-9. doi: 10.1111/vox.12309. Epub 2015 Jul 14.

PMID:
26178178
9.

Comparison of mammalian and bacterial expression library screening to detect recombinant alpha-1 proteinase inhibitor variants with enhanced thrombin inhibitory capacity.

Gierczak RF, Bhakta V, Xie M, Sheffield WP.

J Biotechnol. 2015 Aug 20;208:54-62. doi: 10.1016/j.jbiotec.2015.05.019. Epub 2015 Jun 1.

PMID:
26043905
10.

Fluorous Analogue of Chloramine-T: Preparation, X-ray Structure Determination, and Use as an Oxidant for Radioiodination and s-Tetrazine Synthesis.

Dzandzi JP, Beckford Vera DR, Genady AR, Albu SA, Eltringham-Smith LJ, Capretta A, Sheffield WP, Valliant JF.

J Org Chem. 2015 Jul 17;80(14):7117-25. doi: 10.1021/acs.joc.5b00988. Epub 2015 Jun 24.

PMID:
26030355
11.

Plasma and Plasma Protein Product Transfusion: A Canadian Blood Services Centre for Innovation Symposium.

Zeller MP, Al-Habsi KS, Golder M, Walsh GM, Sheffield WP.

Transfus Med Rev. 2015 Jul;29(3):181-94. doi: 10.1016/j.tmrv.2015.03.003. Epub 2015 Mar 26.

PMID:
25862281
12.

A plasmin-activatable thrombin inhibitor reduces experimental thrombosis and assists experimental thrombolysis in murine models.

Sheffield WP, Eltringham-Smith LJ, Gataiance S, Bhakta V.

J Thromb Thrombolysis. 2015 May;39(4):443-51. doi: 10.1007/s11239-014-1157-3.

PMID:
25481811
13.

The fibrinogen but not the Factor VIII content of transfused plasma determines its effectiveness at reducing bleeding in coagulopathic mice.

Eltringham-Smith LJ, Lei X, Reheman A, Lambourne MD, Pryzdial EL, Ni H, Sheffield WP.

Transfusion. 2015 May;55(5):1040-50. doi: 10.1111/trf.12931. Epub 2014 Nov 18.

PMID:
25403994
14.

Whole blood treated with riboflavin and ultraviolet light: quality assessment of all blood components produced by the buffy coat method.

Schubert P, Culibrk B, Karwal S, Serrano K, Levin E, Bu D, Bhakta V, Sheffield WP, Goodrich RP, Devine DV.

Transfusion. 2015 Apr;55(4):815-23. doi: 10.1111/trf.12895. Epub 2014 Oct 29.

PMID:
25355434
15.

Alpha-1 proteinase inhibitor M358R reduces thrombin generation when displayed on the surface of cells expressing tissue factor.

Gierczak RF, Pepler L, Bhagirath V, Liaw PC, Sheffield WP.

Thromb Res. 2014 Nov;134(5):1142-9. doi: 10.1016/j.thromres.2014.09.002. Epub 2014 Sep 10.

PMID:
25242242
16.

γT -S195A thrombin reduces the anticoagulant effects of dabigatran in vitro and in vivo.

Sheffield WP, Lambourne MD, Eltringham-Smith LJ, Bhakta V, Arnold DM, Crowther MA.

J Thromb Haemost. 2014 Jul;12(7):1110-5. doi: 10.1111/jth.12601. Epub 2014 Jun 19.

17.

Platelet utilization: a Canadian Blood Services research and development symposium.

Webert KE, Alam AQ, Chargé SB, Sheffield WP.

Transfus Med Rev. 2014 Apr;28(2):84-97. doi: 10.1016/j.tmrv.2014.01.002. Epub 2014 Feb 5.

PMID:
24629305
18.

Phage display of the serpin alpha-1 proteinase inhibitor randomized at consecutive residues in the reactive centre loop and biopanned with or without thrombin.

Scott BM, Matochko WL, Gierczak RF, Bhakta V, Derda R, Sheffield WP.

PLoS One. 2014 Jan 10;9(1):e84491. doi: 10.1371/journal.pone.0084491. eCollection 2014.

19.
20.

Expression screening of bacterial libraries of recombinant alpha-1 proteinase inhibitor variants for candidates with thrombin inhibitory capacity.

Bhakta V, Gierczak RF, Sheffield WP.

J Biotechnol. 2013 Dec;168(4):373-81. doi: 10.1016/j.jbiotec.2013.10.011. Epub 2013 Oct 16.

PMID:
24140600
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