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Items: 1 to 20 of 26


Pulmonary Abnormalities in Young, Light-use Waterpipe (Hookah) Smokers.

Strulovici-Barel Y, Shaykhiev R, Salit J, Deeb RS, Krause A, Kaner RJ, Vincent TL, Agosto-Perez F, Wang G, Hollmann C, Shanmugam V, Almulla AM, Sattar H, Mahmoud M, Mezey JG, Gross SS, Staudt MR, Walters MS, Crystal RG.

Am J Respir Crit Care Med. 2016 Mar 23. [Epub ahead of print]


POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes.

Zhou H, Brekman A, Zuo WL, Ou X, Shaykhiev R, Agosto-Perez FJ, Wang R, Walters MS, Salit J, Strulovici-Barel Y, Staudt MR, Kaner RJ, Mezey JG, Crystal RG, Wang G.

J Immunol. 2016 Apr 1;196(7):3159-67. doi: 10.4049/jimmunol.1502400. Epub 2016 Feb 29.


Multitasking basal cells: combining stem cell and innate immune duties.

Shaykhiev R.

Eur Respir J. 2015 Oct;46(4):894-7. doi: 10.1183/13993003.00521-2015. No abstract available.


Early events in the pathogenesis of chronic obstructive pulmonary disease. Smoking-induced reprogramming of airway epithelial basal progenitor cells.

Shaykhiev R, Crystal RG.

Ann Am Thorac Soc. 2014 Dec;11 Suppl 5:S252-8. doi: 10.1513/AnnalsATS.201402-049AW. Review.


Cilia dysfunction in lung disease.

Tilley AE, Walters MS, Shaykhiev R, Crystal RG.

Annu Rev Physiol. 2015;77:379-406. doi: 10.1146/annurev-physiol-021014-071931. Epub 2014 Oct 29. Review.


Airway Basal stem/progenitor cells have diminished capacity to regenerate airway epithelium in chronic obstructive pulmonary disease.

Staudt MR, Buro-Auriemma LJ, Walters MS, Salit J, Vincent T, Shaykhiev R, Mezey JG, Tilley AE, Kaner RJ, Ho MW, Crystal RG.

Am J Respir Crit Care Med. 2014 Oct 15;190(8):955-8. doi: 10.1164/rccm.201406-1167LE. No abstract available.


Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2.

Ryan DM, Vincent TL, Salit J, Walters MS, Agosto-Perez F, Shaykhiev R, Strulovici-Barel Y, Downey RJ, Buro-Auriemma LJ, Staudt MR, Hackett NR, Mezey JG, Crystal RG.

PLoS One. 2014 Feb 3;9(2):e88051. doi: 10.1371/journal.pone.0088051. eCollection 2014.


Basal cell origins of smoking-induced airway epithelial disorders.

Shaykhiev R, Crystal RG.

Cell Cycle. 2014;13(3):341-2. doi: 10.4161/cc.27510. Epub 2013 Dec 13. No abstract available.


Innate immunity and chronic obstructive pulmonary disease: a mini-review.

Shaykhiev R, Crystal RG.

Gerontology. 2013;59(6):481-9. doi: 10.1159/000354173. Epub 2013 Sep 3. Review.


Airway basal cells of healthy smokers express an embryonic stem cell signature relevant to lung cancer.

Shaykhiev R, Wang R, Zwick RK, Hackett NR, Leung R, Moore MA, Sima CS, Chao IW, Downey RJ, Strulovici-Barel Y, Salit J, Crystal RG.

Stem Cells. 2013 Sep;31(9):1992-2002. doi: 10.1002/stem.1459.


EGF shifts human airway basal cell fate toward a smoking-associated airway epithelial phenotype.

Shaykhiev R, Zuo WL, Chao I, Fukui T, Witover B, Brekman A, Crystal RG.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12102-7. doi: 10.1073/pnas.1303058110. Epub 2013 Jul 1.


Lung adenocarcinoma subtypes based on expression of human airway basal cell genes.

Fukui T, Shaykhiev R, Agosto-Perez F, Mezey JG, Downey RJ, Travis WD, Crystal RG.

Eur Respir J. 2013 Nov;42(5):1332-44. doi: 10.1183/09031936.00144012. Epub 2013 May 3.


Smoking-induced CXCL14 expression in the human airway epithelium links chronic obstructive pulmonary disease to lung cancer.

Shaykhiev R, Sackrowitz R, Fukui T, Zuo WL, Chao IW, Strulovici-Barel Y, Downey RJ, Crystal RG.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):418-25. doi: 10.1165/rcmb.2012-0396OC.


RNA-Seq quantification of the human small airway epithelium transcriptome.

Hackett NR, Butler MW, Shaykhiev R, Salit J, Omberg L, Rodriguez-Flores JL, Mezey JG, Strulovici-Barel Y, Wang G, Didon L, Crystal RG.

BMC Genomics. 2012 Feb 29;13:82. doi: 10.1186/1471-2164-13-82.


The human airway epithelial basal cell transcriptome.

Hackett NR, Shaykhiev R, Walters MS, Wang R, Zwick RK, Ferris B, Witover B, Salit J, Crystal RG.

PLoS One. 2011 May 4;6(5):e18378. doi: 10.1371/journal.pone.0018378.


Modulation of cystatin A expression in human airway epithelium related to genotype, smoking, COPD, and lung cancer.

Butler MW, Fukui T, Salit J, Shaykhiev R, Mezey JG, Hackett NR, Crystal RG.

Cancer Res. 2011 Apr 1;71(7):2572-81. doi: 10.1158/0008-5472.CAN-10-2046. Epub 2011 Feb 16.


Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo.

Shaykhiev R, Otaki F, Bonsu P, Dang DT, Teater M, Strulovici-Barel Y, Salit J, Harvey BG, Crystal RG.

Cell Mol Life Sci. 2011 Mar;68(5):877-92. doi: 10.1007/s00018-010-0500-x. Epub 2010 Sep 6.


The antimicrobial peptide cathelicidin enhances activation of lung epithelial cells by LPS.

Shaykhiev R, Sierigk J, Herr C, Krasteva G, Kummer W, Bals R.

FASEB J. 2010 Dec;24(12):4756-66. doi: 10.1096/fj.09-151332. Epub 2010 Aug 9.


Do airway epithelium air-liquid cultures represent the in vivo airway epithelium transcriptome?

Dvorak A, Tilley AE, Shaykhiev R, Wang R, Crystal RG.

Am J Respir Cell Mol Biol. 2011 Apr;44(4):465-73. doi: 10.1165/rcmb.2009-0453OC. Epub 2010 Jun 4.


Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease.

Shaykhiev R, Krause A, Salit J, Strulovici-Barel Y, Harvey BG, O'Connor TP, Crystal RG.

J Immunol. 2009 Aug 15;183(4):2867-83. doi: 10.4049/jimmunol.0900473. Epub 2009 Jul 27.

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