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Results: 1 to 20 of 191


BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells.

Baker EK, Taylor S, Gupte A, Sharp PP, Walia M, Walsh NC, Zannettino AC, Chalk AM, Burns CJ, Walkley CR.

Sci Rep. 2015 May 6;5:10120. doi: 10.1038/srep10120.


Target specificity of the CRISPR-Cas9 system.

Wu X, Kriz AJ, Sharp PA.

Quant Biol. 2014 Jun;2(2):59-70.


Detained introns are a novel, widespread class of post-transcriptionally spliced introns.

Boutz PL, Bhutkar A, Sharp PA.

Genes Dev. 2015 Jan 1;29(1):63-80. doi: 10.1101/gad.247361.114.


CRISPR-mediated direct mutation of cancer genes in the mouse liver.

Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T.

Nature. 2014 Oct 16;514(7522):380-4. doi: 10.1038/nature13589. Epub 2014 Aug 6.


Florida Initiative for Quality Cancer Care: improvements in breast cancer quality indicators during a 3-year interval.

Laronga C, Gray JE, Siegel EM, Lee JH, Fulp WJ, Fletcher M, Schreiber F, Brown R, Levine R, Cartwright T, Abesada-Terk G Jr, Kim G, Alemany C, Faig D, Sharp P, Markham MJ, Shibata D, Malafa M, Jacobsen PB.

J Am Coll Surg. 2014 Oct;219(4):638-45.e1. doi: 10.1016/j.jamcollsurg.2014.03.063. Epub 2014 Jul 1.


LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint.

Dimitrova N, Zamudio JR, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee JT, Sharp PA, Jacks T.

Mol Cell. 2014 Jun 5;54(5):777-90. doi: 10.1016/j.molcel.2014.04.025. Epub 2014 May 22.


RNA Bind-n-Seq: quantitative assessment of the sequence and structural binding specificity of RNA binding proteins.

Lambert N, Robertson A, Jangi M, McGeary S, Sharp PA, Burge CB.

Mol Cell. 2014 Jun 5;54(5):887-900. doi: 10.1016/j.molcel.2014.04.016. Epub 2014 May 15.


Global microRNA depletion suppresses tumor angiogenesis.

Chen S, Xue Y, Wu X, Le C, Bhutkar A, Bell EL, Zhang F, Langer R, Sharp PA.

Genes Dev. 2014 May 15;28(10):1054-67. doi: 10.1101/gad.239681.114. Epub 2014 May 1.


Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells.

Wu X, Scott DA, Kriz AJ, Chiu AC, Hsu PD, Dadon DB, Cheng AW, Trevino AE, Konermann S, Chen S, Jaenisch R, Zhang F, Sharp PA.

Nat Biotechnol. 2014 Jul;32(7):670-6. doi: 10.1038/nbt.2889. Epub 2014 Apr 20.


Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG.

Nat Biotechnol. 2014 Jun;32(6):551-3. doi: 10.1038/nbt.2884. Epub 2014 Mar 30. Erratum in: Nat Biotechnol. 2014 Sep;32(9):952.


Rbfox2 controls autoregulation in RNA-binding protein networks.

Jangi M, Boutz PL, Paul P, Sharp PA.

Genes Dev. 2014 Mar 15;28(6):637-51. doi: 10.1101/gad.235770.113.


Argonaute-bound small RNAs from promoter-proximal RNA polymerase II.

Zamudio JR, Kelly TJ, Sharp PA.

Cell. 2014 Feb 27;156(5):920-34. doi: 10.1016/j.cell.2014.01.041.


Divergent transcription: a driving force for new gene origination?

Wu X, Sharp PA.

Cell. 2013 Nov 21;155(5):990-6. doi: 10.1016/j.cell.2013.10.048.


Promoter directionality is controlled by U1 snRNP and polyadenylation signals.

Almada AE, Wu X, Kriz AJ, Burge CB, Sharp PA.

Nature. 2013 Jul 18;499(7458):360-3. doi: 10.1038/nature12349. Epub 2013 Jun 23.


Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.

Gurtan AM, Ravi A, Rahl PB, Bosson AD, JnBaptiste CK, Bhutkar A, Whittaker CA, Young RA, Sharp PA.

Genes Dev. 2013 Apr 15;27(8):941-54. doi: 10.1101/gad.215376.113.


Molecular biology. A circuitous route to noncoding RNA.

Wilusz JE, Sharp PA.

Science. 2013 Apr 26;340(6131):440-1. doi: 10.1126/science.1238522. No abstract available.


The role of miRNAs in regulating gene expression networks.

Gurtan AM, Sharp PA.

J Mol Biol. 2013 Oct 9;425(19):3582-600. doi: 10.1016/j.jmb.2013.03.007. Epub 2013 Mar 13. Review.


Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells.

Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2876-81. doi: 10.1073/pnas.1221904110. Epub 2013 Feb 4.


Quantifying Argonaute proteins in and out of GW/P-bodies: implications in microRNA activities.

Leung AK, Sharp PA.

Adv Exp Med Biol. 2013;768:165-82. doi: 10.1007/978-1-4614-5107-5_10. Review.


CD44 promotes Kras-dependent lung adenocarcinoma.

Zhao P, Damerow MS, Stern P, Liu AH, Sweet-Cordero A, Siziopikou K, Neilson JR, Sharp PA, Cheng C.

Oncogene. 2013 Oct 24;32(43):5186-90. doi: 10.1038/onc.2012.542. Epub 2012 Dec 3.

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