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Results: 1 to 20 of 153


Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex.

Sewell H, Tanaka T, El Omari K, Mancini EJ, Cruz A, Fernandez-Fuentes N, Chambers J, Rabbitts TH.

Sci Rep. 2014 Jan 10;4:3643. doi: 10.1038/srep03643.


An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells.

Sharquie IK, Al-Ghouleh A, Fitton P, Clark MR, Armour KL, Sewell HF, Shakib F, Ghaemmaghami AM.

BMC Immunol. 2013 Dec 13;14:54. doi: 10.1186/1471-2172-14-54.


Breach of race equality duties.

Sewell H.

Nurs Stand. 2013 Oct 30-Nov 5;28(9):65. doi: 10.7748/ns2013. No abstract available.


Circulating antibody and memory B-Cell responses to C. difficile toxins A and B in patients with C. difficile-associated diarrhoea, inflammatory bowel disease and cystic fibrosis.

Monaghan TM, Robins A, Knox A, Sewell HF, Mahida YR.

PLoS One. 2013 Sep 10;8(9):e74452. doi: 10.1371/journal.pone.0074452. eCollection 2013.


The role of lectins in allergic sensitization and allergic disease.

Salazar F, Sewell HF, Shakib F, Ghaemmaghami AM.

J Allergy Clin Immunol. 2013 Jul;132(1):27-36. doi: 10.1016/j.jaci.2013.02.001. Epub 2013 Mar 25. Review.


Application of a high throughput method of biomarker discovery to improvement of the EarlyCDT(®)-Lung Test.

Macdonald IK, Murray A, Healey GF, Parsy-Kowalska CB, Allen J, McElveen J, Robertson C, Sewell HF, Chapman CJ, Robertson JF.

PLoS One. 2012;7(12):e51002. doi: 10.1371/journal.pone.0051002. Epub 2012 Dec 13.


Development and validation of a high throughput system for discovery of antigens for autoantibody detection.

Macdonald IK, Allen J, Murray A, Parsy-Kowalska CB, Healey GF, Chapman CJ, Sewell HF, Robertson JF.

PLoS One. 2012;7(7):e40759. doi: 10.1371/journal.pone.0040759. Epub 2012 Jul 18.


The effect of an intercalated BSc on subsequent academic performance.

Mahesan N, Crichton S, Sewell H, Howell S.

BMC Med Educ. 2011 Oct 3;11:76. doi: 10.1186/1472-6920-11-76.


EarlyCDT-Lung: an immunobiomarker test as an aid to early detection of lung cancer.

Lam S, Boyle P, Healey GF, Maddison P, Peek L, Murray A, Chapman CJ, Allen J, Wood WC, Sewell HF, Robertson JF.

Cancer Prev Res (Phila). 2011 Jul;4(7):1126-34. doi: 10.1158/1940-6207.CAPR-10-0328.


Differential binding and internalization of Clostridium difficile toxin A by human peripheral blood monocytes, neutrophils and lymphocytes.

Modi N, Gulati N, Solomon K, Monaghan T, Robins A, Sewell HF, Mahida YR.

Scand J Immunol. 2011 Sep;74(3):264-71. doi: 10.1111/j.1365-3083.2011.02578.x.


Recognition of the major cat allergen Fel d 1 through the cysteine-rich domain of the mannose receptor determines its allergenicity.

Emara M, Royer PJ, Abbas Z, Sewell HF, Mohamed GG, Singh S, Peel S, Fox J, Shakib F, Martinez-Pomares L, Ghaemmaghami AM.

J Biol Chem. 2011 Apr 15;286(15):13033-40. doi: 10.1074/jbc.M111.220657. Epub 2011 Feb 18.


Smaller budgets will have bigger impacts for social care.

Sewell H.

Ment Health Today. 2010 Dec-2011 Jan:20. No abstract available.


Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain.

Tanaka T, Sewell H, Waters S, Phillips SE, Rabbitts TH.

J Biol Chem. 2011 Feb 4;286(5):3707-16. doi: 10.1074/jbc.M110.188193. Epub 2010 Oct 27.


The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity.

Royer PJ, Emara M, Yang C, Al-Ghouleh A, Tighe P, Jones N, Sewell HF, Shakib F, Martinez-Pomares L, Ghaemmaghami AM.

J Immunol. 2010 Aug 1;185(3):1522-31. doi: 10.4049/jimmunol.1000774. Epub 2010 Jul 7.


Technical validation of an autoantibody test for lung cancer.

Murray A, Chapman CJ, Healey G, Peek LJ, Parsons G, Baldwin D, Barnes A, Sewell HF, Fritsche HA, Robertson JF.

Ann Oncol. 2010 Aug;21(8):1687-93. doi: 10.1093/annonc/mdp606. Epub 2010 Feb 2.


Differential protein expression by dendritic cells from atopic and non-atopic individuals after stimulation by the major house dust mite allergen Der p 1.

Horlock C, Shakib F, Jones NS, Sewell HF, Ghaemmaghami AM.

Int Arch Allergy Immunol. 2009;150(3):237-51. doi: 10.1159/000222676. Epub 2009 Jun 4.


Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia.

Appert A, Nam CH, Lobato N, Priego E, Miguel RN, Blundell T, Drynan L, Sewell H, Tanaka T, Rabbitts T.

Cancer Res. 2009 Jun 1;69(11):4784-90. doi: 10.1158/0008-5472.CAN-08-4774.


Allergen-driven suppression of thiol production by human dendritic cells and the effect of thiols on T cell function.

Hasan AA, Ghaemmaghami AM, Fairclough L, Robins A, Sewell HF, Shakib F.

Immunobiology. 2009;214(1):2-16. doi: 10.1016/j.imbio.2008.04.006. Epub 2008 Jun 20.


The molecular basis of allergenicity.

Shakib F, Ghaemmaghami AM, Sewell HF.

Trends Immunol. 2008 Dec;29(12):633-42. doi: 10.1016/ Epub 2008 Oct 24. Review.


An immunoglobulin E-reactive chimeric human immunoglobulin G1 anti-idiotype inhibits basophil degranulation through cross-linking of FcepsilonRI with FcgammaRIIb.

Wigginton SJ, Furtado PB, Armour KL, Clark MR, Robins A, Emara M, Ghaemmaghami AM, Sewell HF, Shakib F.

Clin Exp Allergy. 2008 Feb;38(2):313-9. Epub 2007 Dec 7.

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