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Results: 1 to 20 of 164

1.

2-Hexylthio-β,γ-CH2-ATP is an effective and selective NTPDase2 inhibitor.

Gillerman I, Lecka J, Simhaev L, Munkonda MN, Fausther M, Martín-Satué M, Senderowitz H, Sévigny J, Fischer B.

J Med Chem. 2014 Jun 27. [Epub ahead of print]

PMID:
24972256
[PubMed - as supplied by publisher]
2.

Highly Potent and Selective Ectonucleotide Pyrophosphatase/Phosphodiesterase I Inhibitors Based on an Adenosine 5'-(α or γ)-Thio-(α,β- or β,γ)-methylenetriphosphate Scaffold.

Nadel Y, Lecka J, Gilad Y, Ben-David G, Förster D, Reiser G, Kenigsberg S, Camden J, Weisman GA, Senderowitz H, Sévigny J, Fischer B.

J Med Chem. 2014 Jun 12;57(11):4677-91. doi: 10.1021/jm500196c. Epub 2014 May 30.

PMID:
24846781
[PubMed - in process]
3.

NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression.

Rockenbach L, Braganhol E, Dietrich F, Figueiró F, Pugliese M, Edelweiss MI, Morrone FB, Sévigny J, Battastini AM.

Purinergic Signal. 2014 Jan 26. [Epub ahead of print]

PMID:
24464643
[PubMed - as supplied by publisher]
4.

Identification of sulfonic acids as efficient ecto-5'-nucleotidase inhibitors.

Iqbal J, Saeed A, Raza R, Matin A, Hameed A, Furtmann N, Lecka J, Sévigny J, Bajorath J.

Eur J Med Chem. 2013 Dec;70:685-91. doi: 10.1016/j.ejmech.2013.10.053. Epub 2013 Oct 28.

PMID:
24215819
[PubMed - in process]
5.

Ca2+ responses in enteric glia are mediated by connexin-43 hemichannels and modulate colonic transit in mice.

McClain JL, Grubišić V, Fried D, Gomez-Suarez RA, Leinninger GM, Sévigny J, Parpura V, Gulbransen BD.

Gastroenterology. 2014 Feb;146(2):497-507.e1. doi: 10.1053/j.gastro.2013.10.061. Epub 2013 Nov 6.

PMID:
24211490
[PubMed - indexed for MEDLINE]
6.

Altered lipid and salt taste responsivity in ghrelin and GOAT null mice.

Cai H, Cong WN, Daimon CM, Wang R, Tschöp MH, Sévigny J, Martin B, Maudsley S.

PLoS One. 2013 Oct 4;8(10):e76553. doi: 10.1371/journal.pone.0076553. eCollection 2013.

PMID:
24124572
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Nonhydrolyzable ATP analogues as selective inhibitors of human NPP1: a combined computational/experimental study.

Lecka J, Ben-David G, Simhaev L, Eliahu S, Oscar J Jr, Luyindula P, Pelletier J, Fischer B, Senderowitz H, Sévigny J.

J Med Chem. 2013 Nov 14;56(21):8308-20. doi: 10.1021/jm400918s. Epub 2013 Oct 22.

PMID:
24083941
[PubMed - indexed for MEDLINE]
8.

Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators.

Cai H, Daimon CM, Cong WN, Wang R, Chirdon P, de Cabo R, Sévigny J, Maudsley S, Martin B.

J Gerontol A Biol Sci Med Sci. 2014 May;69(5):532-44. doi: 10.1093/gerona/glt129. Epub 2013 Sep 28.

PMID:
24077597
[PubMed - indexed for MEDLINE]
9.

Homocysteine modifies extracellular ATP availability in macrophages.

Zanin RF, Bergamin LS, Braganhol E, Sévigny J, de Souza Wyse AT, Battastini AM.

Toxicol In Vitro. 2013 Dec;27(8):2273-8. doi: 10.1016/j.tiv.2013.09.001. Epub 2013 Sep 19.

PMID:
24055814
[PubMed - indexed for MEDLINE]
10.

Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferation.

Pinheiro AR, Paramos-de-Carvalho D, Certal M, Costa MA, Costa C, Magalhães-Cardoso MT, Ferreirinha F, Sévigny J, Correia-de-Sá P.

J Biol Chem. 2013 Sep 20;288(38):27571-83. doi: 10.1074/jbc.M113.460865. Epub 2013 Aug 5.

PMID:
23918924
[PubMed - indexed for MEDLINE]
11.

Nucleoside-(5'→P) methylenebisphosphonodithioate analogues: synthesis and chemical properties.

Meltzer D, Nadel Y, Lecka J, Amir A, Sévigny J, Fischer B.

J Org Chem. 2013 Sep 6;78(17):8320-9. doi: 10.1021/jo400931n. Epub 2013 Aug 12.

PMID:
23895237
[PubMed - indexed for MEDLINE]
12.

Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions.

Augusto E, Matos M, Sévigny J, El-Tayeb A, Bynoe MS, Müller CE, Cunha RA, Chen JF.

J Neurosci. 2013 Jul 10;33(28):11390-9. doi: 10.1523/JNEUROSCI.5817-12.2013.

PMID:
23843511
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases.

al-Rashida M, Raza R, Abbas G, Shah MS, Kostakis GE, Lecka J, Sévigny J, Muddassar M, Papatriantafyllopoulou C, Iqbal J.

Eur J Med Chem. 2013 Aug;66:438-49. doi: 10.1016/j.ejmech.2013.06.015. Epub 2013 Jun 19.

PMID:
23831808
[PubMed - indexed for MEDLINE]
14.

Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the "adenosine hypothesis".

Aliagas E, Villar-Menéndez I, Sévigny J, Roca M, Romeu M, Ferrer I, Martín-Satué M, Barrachina M.

Purinergic Signal. 2013 Dec;9(4):599-608. doi: 10.1007/s11302-013-9370-7. Epub 2013 Jun 16.

PMID:
23771238
[PubMed - in process]
Free PMC Article
15.

Regulatory T cells negatively affect IL-2 production of effector T cells through CD39/adenosine pathway in HIV infection.

Jenabian MA, Seddiki N, Yatim A, Carriere M, Hulin A, Younas M, Ghadimi E, Kök A, Routy JP, Tremblay A, Sévigny J, Lelievre JD, Levy Y.

PLoS Pathog. 2013;9(4):e1003319. doi: 10.1371/journal.ppat.1003319. Epub 2013 Apr 25.

PMID:
23658513
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Attenuated allergic airway inflammation in Cd39 null mice.

Idzko M, K Ayata C, Müller T, Dürk T, Grimm M, Baudiß K, Vieira RP, Cicko S, Boehlke C, Zech A, Sorichter S, Pelletier J, Sévigny J, Robson SC.

Allergy. 2013 Apr;68(4):472-80. doi: 10.1111/all.12119. Epub 2013 Mar 1.

PMID:
23452076
[PubMed - indexed for MEDLINE]
17.

8-BuS-ATP derivatives as specific NTPDase1 inhibitors.

Lecka J, Gillerman I, Fausther M, Salem M, Munkonda MN, Brosseau JP, Cadot C, Martín-Satué M, d'Orléans-Juste P, Rousseau E, Poirier D, Künzli B, Fischer B, Sévigny J.

Br J Pharmacol. 2013 May;169(1):179-96. doi: 10.1111/bph.12135.

PMID:
23425137
[PubMed - in process]
Free PMC Article
18.

Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium.

Aliagas E, Vidal A, Torrejón-Escribano B, Taco Mdel R, Ponce J, de Aranda IG, Sévigny J, Condom E, Martín-Satué M.

Purinergic Signal. 2013 Jun;9(2):227-37. doi: 10.1007/s11302-012-9345-0. Epub 2012 Dec 6.

PMID:
23225236
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

A highly sensitive capillary electrophoresis method using p-nitrophenyl 5'-thymidine monophosphate as a substrate for the monitoring of nucleotide pyrophosphatase/phosphodiesterase activities.

Lee SY, Lévesque SA, Sévigny J, Müller CE.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Dec 12;911:162-9. doi: 10.1016/j.jchromb.2012.10.044. Epub 2012 Nov 7.

PMID:
23217320
[PubMed - indexed for MEDLINE]
20.

Identification of small molecule sulfonic acids as ecto-5'-Nucleotidase inhibitors.

Raza R, Saeed A, Lecka J, Sévigny J, Iqbal J.

Med Chem. 2012 Nov;8(6):1133-9.

PMID:
22741787
[PubMed - indexed for MEDLINE]

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