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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 3
1967 1
1971 2
1974 2
1976 1
1977 1
1979 1
1981 4
1982 3
1983 2
1984 5
1985 7
1986 5
1987 8
1988 8
1989 5
1990 6
1991 5
1992 6
1993 2
1994 3
1995 2
1996 5
1997 3
1998 4
1999 4
2000 1
2001 2
2002 6
2003 3
2004 8
2005 7
2006 1
2007 3
2008 4
2009 6
2010 7
2011 7
2013 5
2014 10
2015 15
2016 2
2017 9
2018 9
2019 13
2020 9
2021 17
2022 13
2023 4
2024 2

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243 results

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Page 1
Detection of Senecionine in Dietary Sources by Single-Use Electrochemical Sensor.
Senturk H, Eksin E, Zeybek U, Erdem A. Senturk H, et al. Micromachines (Basel). 2021 Dec 20;12(12):1585. doi: 10.3390/mi12121585. Micromachines (Basel). 2021. PMID: 34945435 Free PMC article.
For the first time in the literature, a simple and inexpensive electrochemical assay based on a single-use sensor was introduced for quantitative determination of senecionine (SEN) in the most frequently contaminated food sources. ...
For the first time in the literature, a simple and inexpensive electrochemical assay based on a single-use sensor was introduced for quantit …
Bear bile powder attenuates senecionine-induced hepatic sinusoidal obstruction syndrome in mice.
Jiang KY, Zhang Y, Ye XL, Xiong F, Chen Y, Jia XL, Zhang YX, Yang L, Xiong AZ, Wang ZT. Jiang KY, et al. Chin J Nat Med. 2022 Apr;20(4):270-281. doi: 10.1016/S1875-5364(22)60169-9. Chin J Nat Med. 2022. PMID: 35487597
Here, we aim to evaluate the protective effect of BBP against HSOS induced by senecionine, a highly hepatotoxic PA compound. Our results showed that BBP treatment protected mice from senecionine-induced HSOS dose-dependently, which was evident by improved liver hist …
Here, we aim to evaluate the protective effect of BBP against HSOS induced by senecionine, a highly hepatotoxic PA compound. Our resu …
The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice.
Hessel-Pras S, Braeuning A, Guenther G, Adawy A, Enge AM, Ebmeyer J, Henderson CJ, Hengstler JG, Lampen A, Reif R. Hessel-Pras S, et al. Arch Toxicol. 2020 Jan;94(1):219-229. doi: 10.1007/s00204-019-02582-8. Epub 2019 Oct 12. Arch Toxicol. 2020. PMID: 31606820
In vitro experiments showed no cytotoxicity to freshly isolated LSECs up to 500 M senecionine. However, metabolic activation of senecionine by preincubation with primary mouse hepatocytes increased the cytotoxicity to cultivated LSECs with an EC(50) of approximately …
In vitro experiments showed no cytotoxicity to freshly isolated LSECs up to 500 M senecionine. However, metabolic activation of se …
Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice.
Yang X, Wang H, Ni HM, Xiong A, Wang Z, Sesaki H, Ding WX, Yang L. Yang X, et al. Redox Biol. 2017 Aug;12:264-273. doi: 10.1016/j.redox.2017.02.020. Epub 2017 Mar 2. Redox Biol. 2017. PMID: 28282614 Free PMC article.
We found that senecionine administration increased serum alanine aminotransferase levels in mice. ...SP600125, a specific JNK inhibitor, and ZVAD-fmk, a general caspase inhibitor, alleviated senecionine-induced apoptosis in primary hepatocytes. Interestingly, sen …
We found that senecionine administration increased serum alanine aminotransferase levels in mice. ...SP600125, a specific JNK inhibit …
Physiologically based kinetic modeling of senecionine N-oxide in rats as a new approach methodology to define the effects of dose and endpoint used on relative potency values of pyrrolizidine alkaloid N-oxides.
Widjaja F, Zheng L, Wesseling S, Rietjens IMCM. Widjaja F, et al. Front Pharmacol. 2023 Mar 2;14:1125146. doi: 10.3389/fphar.2023.1125146. eCollection 2023. Front Pharmacol. 2023. PMID: 36937884 Free PMC article.
PA-N-oxides are toxic when reduced to their parent PAs, which are bioactivated into pyrrole intermediates that generate protein- and DNA-adducts resulting in liver toxicity and carcinogenicity. Literature data for senecionine N-oxide in rats indicate that the relative pote …
PA-N-oxides are toxic when reduced to their parent PAs, which are bioactivated into pyrrole intermediates that generate protein- and DNA-add …
Firm evidence for the detoxification of senecionine-induced hepatotoxicity via N-glucuronidation in UGT1A4-humanized transgenic mice.
Chen Y, Wang WQ, Jia XL, Wang CH, Yang L, Wang ZT, Xiong AZ. Chen Y, et al. Food Chem Toxicol. 2022 Jul;165:113185. doi: 10.1016/j.fct.2022.113185. Epub 2022 May 27. Food Chem Toxicol. 2022. PMID: 35636643
As results, senecionine-induced toxicity was significantly decreased as approved by mortality, pathology, and biochemistry assays in hUGT1A4 mice and cultured primary hepatocytes. ...Conclusively, UGT1A4 plays an important role in detoxification of senecionine and t …
As results, senecionine-induced toxicity was significantly decreased as approved by mortality, pathology, and biochemistry assays in …
Identification of microRNAs Implicated in Modulating Senecionine-Induced Liver Toxicity in HepaRG Cells.
Enge AM, Sprenger H, Braeuning A, Hessel-Pras S. Enge AM, et al. Foods. 2022 Feb 12;11(4):532. doi: 10.3390/foods11040532. Foods. 2022. PMID: 35206009 Free PMC article.
Beyond that, nuclear receptor activation has only been observed for one receptor and two PAs, yielding the possibility that other cellular mediators are involved in PA-mediated toxicity. Here, the mode of action of Senecionine (Sc), a prominent and ubiquitous representativ …
Beyond that, nuclear receptor activation has only been observed for one receptor and two PAs, yielding the possibility that other cellular m …
Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver.
Miranda CL, Reed RL, Guengerich FP, Buhler DR. Miranda CL, et al. Carcinogenesis. 1991 Mar;12(3):515-9. doi: 10.1093/carcin/12.3.515. Carcinogenesis. 1991. PMID: 2009596
Human liver microsomes metabolized senecionine to two major products, (+/-)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP) and senecionine N-oxide. ...At 5 mg IgG/nmol P450, anti-P450IIIA4 inhibited 90 and 84% respectively of the formation of DHP and …
Human liver microsomes metabolized senecionine to two major products, (+/-)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP …
Species difference in toxicokinetics and safety assessment of senecionine N-oxide in a UDP-glucuronosyltransferase 1A4 humanized mouse model.
Chen Y, Tang Y, Liu P, Wang J, Wang W, Wang C, Ding L, Xiong A, Yang L, Wang Z. Chen Y, et al. Chem Biol Interact. 2023 Aug 1;380:110505. doi: 10.1016/j.cbi.2023.110505. Epub 2023 Apr 18. Chem Biol Interact. 2023. PMID: 37080376
The variation in toxicokinetic characteristics was also observed between hUGT1A4 mice and WT mice with a notably enhanced clearance of senecionine N-oxide and senecionine, and accordingly less formation of pyrrole-protein adducts in hUGT1A4 mice, which finally led t …
The variation in toxicokinetic characteristics was also observed between hUGT1A4 mice and WT mice with a notably enhanced clearance of se …
Organic Cation Transporter I and Na(+) /taurocholate Co-Transporting Polypeptide are Involved in Retrorsine- and Senecionine-Induced Hepatotoxicity in HepaRG cells.
Enge AM, Kaltner F, Gottschalk C, Kin A, Kirstgen M, Geyer J, These A, Hammer H, Pötz O, Braeuning A, Hessel-Pras S. Enge AM, et al. Mol Nutr Food Res. 2022 Jan;66(2):e2100800. doi: 10.1002/mnfr.202100800. Epub 2021 Dec 11. Mol Nutr Food Res. 2022. PMID: 34826203
METHODS AND RESULTS: We show that transporter expression levels are significantly affected by treatment with the PAs senecionine (Sc) and retrorsine (Re) in the human hepatoma cell line HepaRG. ...
METHODS AND RESULTS: We show that transporter expression levels are significantly affected by treatment with the PAs senecionine (Sc) …
243 results