Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 378

1.

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid.

Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ.

Alzheimers Res Ther. 2015 Mar 22;7(1):14. doi: 10.1186/s13195-015-0100-y. eCollection 2015.

2.

Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.

Luth ES, Bartels T, Dettmer U, Kim NC, Selkoe DJ.

Biochemistry. 2015 Jan 20;54(2):279-92. doi: 10.1021/bi501188a. Epub 2014 Dec 23.

PMID:
25490121
3.

N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation.

Bartels T, Kim NC, Luth ES, Selkoe DJ.

PLoS One. 2014 Jul 30;9(7):e103727. doi: 10.1371/journal.pone.0103727. eCollection 2014.

4.

Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes.

Renella R, Schlehe JS, Selkoe DJ, Williams DA, LaVoie MJ.

Am J Hematol. 2014 Oct;89(10):974-7. doi: 10.1002/ajh.23796. Epub 2014 Jul 21.

PMID:
25043722
5.

γ-Secretase: a horseshoe structure brings good luck.

Wolfe MS, Selkoe DJ.

Cell. 2014 Jul 17;158(2):247-9. doi: 10.1016/j.cell.2014.06.043.

PMID:
25036627
6.

Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.

Luth ES, Stavrovskaya IG, Bartels T, Kristal BS, Selkoe DJ.

J Biol Chem. 2014 Aug 1;289(31):21490-507. doi: 10.1074/jbc.M113.545749. Epub 2014 Jun 18.

PMID:
24942732
7.

Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis.

Holmes O, Paturi S, Selkoe DJ, Wolfe MS.

Biochemistry. 2014 Jul 15;53(27):4393-406. doi: 10.1021/bi500489j. Epub 2014 Jun 30.

PMID:
24941111
8.

Functional analysis and purification of a Pen-2 fusion protein for γ-secretase structural studies.

Holmes O, Paturi S, Wolfe MS, Selkoe DJ.

J Neurochem. 2014 Oct;131(1):94-100. doi: 10.1111/jnc.12772. Epub 2014 Jun 18.

PMID:
24865334
9.

Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity.

Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ.

Biochemistry. 2014 Jun 24;53(24):3908-21.

10.

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Hong S, Ostaszewski BL, Yang T, O'Malley TT, Jin M, Yanagisawa K, Li S, Bartels T, Selkoe DJ.

Neuron. 2014 Apr 16;82(2):308-19. doi: 10.1016/j.neuron.2014.02.027. Epub 2014 Mar 27.

11.

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons.

Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL.

Hum Mol Genet. 2014 Jul 1;23(13):3523-36. doi: 10.1093/hmg/ddu064. Epub 2014 Feb 12.

PMID:
24524897
12.

Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study.

Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, Gomperts SN, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Hyman BT, Sudarsky LR, Growdon JH, Scherzer CR.

Neurology. 2013 Oct 22;81(17):1531-7. doi: 10.1212/WNL.0b013e3182a95818. Epub 2013 Sep 25.

13.

The therapeutics of Alzheimer's disease: Where we stand and where we are heading.

Selkoe DJ.

Ann Neurol. 2013 Sep;74(3):328-36. doi: 10.1002/ana.24001.

PMID:
25813842
14.

SnapShot: pathobiology of Alzheimer's disease.

Selkoe DJ.

Cell. 2013 Jul 18;154(2):468-468.e1. doi: 10.1016/j.cell.2013.07.003. No abstract available.

15.

Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein.

Rice HC, Young-Pearse TL, Selkoe DJ.

Biochemistry. 2013 May 14;52(19):3264-77. doi: 10.1021/bi400165f. Epub 2013 May 2.

16.

Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.

Koeglsperger T, Li S, Brenneis C, Saulnier JL, Mayo L, Carrier Y, Selkoe DJ, Weiner HL.

Glia. 2013 Jun;61(6):985-1002. doi: 10.1002/glia.22490. Epub 2013 Mar 28.

17.

Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.

Li S, Jin M, Zhang D, Yang T, Koeglsperger T, Fu H, Selkoe DJ.

Neuron. 2013 Mar 6;77(5):929-41. doi: 10.1016/j.neuron.2012.12.040.

18.

New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF.

Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ.

Alzheimers Dement. 2013 Mar;9(2):99-112. doi: 10.1016/j.jalz.2012.11.005. Epub 2013 Jan 30.

19.

Alzheimer disease in 2020.

Holtzman DM, Mandelkow E, Selkoe DJ.

Cold Spring Harb Perspect Med. 2012 Nov 1;2(11). pii: a011585. doi: 10.1101/cshperspect.a011585. Review.

20.

Preventing Alzheimer's disease.

Selkoe DJ.

Science. 2012 Sep 21;337(6101):1488-92.

PMID:
22997326
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Loading ...
Write to the Help Desk