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Results: 1 to 20 of 38

1.

Akt signaling leads to stem cell activation and promotes tumor development in epidermis.

Segrelles C, García-Escudero R, Garín MI, Aranda JF, Hernández P, Ariza JM, Santos M, Paramio JM, Lorz C.

Stem Cells. 2014 Jul;32(7):1917-28. doi: 10.1002/stem.1669.

PMID:
24504902
2.

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia.

Saiz-Ladera C, Lara MF, Garín M, Ruiz S, Santos M, Lorz C, García-Escudero R, Martínez-Fernández M, Bravo A, Fernández-Capetillo O, Segrelles C, Paramio JM.

Oncogene. 2014 Sep 11;33(37):4599-612. doi: 10.1038/onc.2013.417. Epub 2013 Oct 14.

PMID:
24121270
3.

A novel tumor suppressor network in squamous malignancies.

Costa C, Santos M, Segrelles C, Dueñas M, Lara MF, Agirre X, Prosper F, García-Escudero R, Paramio JM.

Sci Rep. 2012;2:828. doi: 10.1038/srep00828. Epub 2012 Nov 9.

4.

EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours.

Bornachea O, Santos M, Martínez-Cruz AB, García-Escudero R, Dueñas M, Costa C, Segrelles C, Lorz C, Buitrago A, Saiz-Ladera C, Agirre X, Grande T, Paradela B, Maraver A, Ariza JM, Prosper F, Serrano M, Sánchez-Céspedes M, Paramio JM.

Sci Rep. 2012;2:434. doi: 10.1038/srep00434. Epub 2012 May 31.

5.

The thyroid hormone receptors modulate the skin response to retinoids.

García-Serrano L, Gomez-Ferrería MA, Contreras-Jurado C, Segrelles C, Paramio JM, Aranda A.

PLoS One. 2011;6(8):e23825. doi: 10.1371/journal.pone.0023825. Epub 2011 Aug 17.

6.

Establishment of a murine epidermal cell line suitable for in vitro and in vivo skin modelling.

Segrelles C, Holguín A, Hernández P, Ariza JM, Paramio JM, Lorz C.

BMC Dermatol. 2011 Apr 21;11:9. doi: 10.1186/1471-5945-11-9.

7.

Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy.

García-Escudero R, Martínez-Cruz AB, Santos M, Lorz C, Segrelles C, Garaulet G, Saiz-Ladera C, Costa C, Buitrago-Pérez A, Dueñas M, Paramio JM.

Mol Cancer. 2010 Jul 14;9:193. doi: 10.1186/1476-4598-9-193.

8.

A functional role of RB-dependent pathway in the control of quiescence in adult epidermal stem cells revealed by genomic profiling.

Lorz C, García-Escudero R, Segrelles C, Garín MI, Ariza JM, Santos M, Ruiz S, Lara MF, Martínez-Cruz AB, Costa C, Buitrago-Pérez A, Saiz-Ladera C, Dueñas M, Paramio JM.

Stem Cell Rev. 2010 Jun;6(2):162-77. doi: 10.1007/s12015-010-9139-0.

9.

Isolation of adult mouse stem keratinocytes using magnetic cell sorting (MACS).

Lorz C, Segrelles C, Garín M, Paramio JM.

Methods Mol Biol. 2010;585:1-11. doi: 10.1007/978-1-60761-380-0_1.

PMID:
19907992
10.

Transgenic mice expressing constitutively active Akt in oral epithelium validate KLFA as a potential biomarker of head and neck squamous cell carcinoma.

Moral M, Segrelles C, Martínez-Cruz AB, Lorz C, Santos M, García-Escudero R, Lu J, Buitrago A, Costa C, Saiz C, Ariza JM, Dueñas M, Rodriguez-Peralto JL, Martinez-Tello FJ, Rodriguez-Pinilla M, Sanchez-Cespedes M, Digiovanni J, Paramio JM.

In Vivo. 2009 Sep-Oct;23(5):653-60.

11.

Spontaneous tumor formation in Trp53-deficient epidermis mediated by chromosomal instability and inflammation.

Martínez-Cruz AB, Santos M, García-Escudero R, Moral M, Segrelles C, Lorz C, Saiz C, Buitrago-Pérez A, Costa C, Paramio JM.

Anticancer Res. 2009 Aug;29(8):3035-42.

12.

On the origin of epidermal cancers.

Lorz C, Segrelles C, Paramio JM.

Curr Mol Med. 2009 Apr;9(3):353-64. Review.

PMID:
19355916
13.

Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma.

Moral M, Segrelles C, Lara MF, Martínez-Cruz AB, Lorz C, Santos M, García-Escudero R, Lu J, Kiguchi K, Buitrago A, Costa C, Saiz C, Rodriguez-Peralto JL, Martinez-Tello FJ, Rodriguez-Pinilla M, Sanchez-Cespedes M, Garín M, Grande T, Bravo A, DiGiovanni J, Paramio JM.

Cancer Res. 2009 Feb 1;69(3):1099-108. doi: 10.1158/0008-5472.CAN-08-3240. Epub 2009 Jan 27.

14.

Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage.

Santos M, Ruiz S, Lara MF, Segrelles C, Moral M, Martínez-Cruz AB, Ballestín C, Lorz C, García-Escudero R, Paramio JM.

Mol Carcinog. 2008 Nov;47(11):815-21. doi: 10.1002/mc.20426.

PMID:
18300254
15.

Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors.

Martínez-Cruz AB, Santos M, Lara MF, Segrelles C, Ruiz S, Moral M, Lorz C, García-Escudero R, Paramio JM.

Cancer Res. 2008 Feb 1;68(3):683-92. doi: 10.1158/0008-5472.CAN-07-3049.

16.

Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis.

Segrelles C, Lu J, Hammann B, Santos M, Moral M, Cascallana JL, Lara MF, Rho O, Carbajal S, Traag J, Beltrán L, Martínez-Cruz AB, García-Escudero R, Lorz C, Ruiz S, Bravo A, Paramio JM, DiGiovanni J.

Cancer Res. 2007 Nov 15;67(22):10879-88.

17.

Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling.

Segrelles C, Moral M, Lorz C, Santos M, Lu J, Cascallana JL, Lara MF, Carbajal S, Martínez-Cruz AB, García-Escudero R, Beltran L, Segovia JC, Bravo A, DiGiovanni J, Paramio JM.

Mol Biol Cell. 2008 Jan;19(1):137-49. Epub 2007 Oct 24.

18.

Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis.

Lara MF, García-Escudero R, Ruiz S, Santos M, Moral M, Martínez-Cruz AB, Segrelles C, Lorz C, Paramio JM.

Mol Carcinog. 2008 Mar;47(3):209-21.

PMID:
17932948
19.

p107 acts as a tumor suppressor in pRb-deficient epidermis.

Lara MF, Santos M, Ruiz S, Segrelles C, Moral M, Martínez-Cruz AB, Hernández P, Martínez-Palacio J, Lorz C, García-Escudero R, Paramio JM.

Mol Carcinog. 2008 Feb;47(2):105-13.

PMID:
17932945
20.

Unexpected roles for pRb in mouse skin carcinogenesis.

Ruiz S, Santos M, Lara MF, Segrelles C, Ballestín C, Paramio JM.

Cancer Res. 2005 Nov 1;65(21):9678-86.

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