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Results: 1 to 20 of 408

1.

Maternal depressive symptoms throughout pregnancy are associated with increased placental glucocorticoid sensitivity.

Reynolds RM, Pesonen AK, O'Reilly JR, Tuovinen S, Lahti M, Kajantie E, Villa PM, Laivuori H, Hämäläinen E, Seckl JR, Räikkönen K.

Psychol Med. 2015 Jan 28:1-8. [Epub ahead of print]

PMID:
25628053
2.

Diurnal and stress-induced intra-hippocampal corticosterone rise attenuated in 11β-HSD1-deficient mice: a microdialysis study in young and aged mice.

Yau JL, Noble J, Kenyon CJ, Ludwig M, Seckl JR.

Eur J Neurosci. 2015 Mar;41(6):787-92. doi: 10.1111/ejn.12836. Epub 2015 Jan 23.

PMID:
25614240
3.

5α-Reduced neurosteroids sex-dependently reverse central prenatal programming of neuroendocrine stress responses in rats.

Brunton PJ, Donadio MV, Yao ST, Greenwood M, Seckl JR, Murphy D, Russell JA.

J Neurosci. 2015 Jan 14;35(2):666-77. doi: 10.1523/JNEUROSCI.5104-13.2015.

4.

Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice.

Wheelan N, Webster SP, Kenyon CJ, Caughey S, Walker BR, Holmes MC, Seckl JR, Yau JL.

Neuropharmacology. 2015 Apr;91:71-6. doi: 10.1016/j.neuropharm.2014.12.005. Epub 2014 Dec 11.

5.

Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion.

Michailidou Z, Morton NM, Moreno Navarrete JM, West CC, Stewart KJ, Fernández-Real JM, Schofield CJ, Seckl JR, Ratcliffe PJ.

Diabetes. 2015 Mar;64(3):733-45. doi: 10.2337/db14-0233. Epub 2014 Nov 5.

PMID:
25377876
6.

β-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction.

Liu X, Turban S, Carter RN, Ahmad S, Ramage L, Webster SP, Walker BR, Seckl JR, Morton NM.

Front Endocrinol (Lausanne). 2014 Oct 14;5:165. doi: 10.3389/fendo.2014.00165. eCollection 2014.

7.

Cholestenoic acids regulate motor neuron survival via liver X receptors.

Theofilopoulos S, Griffiths WJ, Crick PJ, Yang S, Meljon A, Ogundare M, Kitambi SS, Lockhart A, Tuschl K, Clayton PT, Morris AA, Martinez A, Reddy MA, Martinuzzi A, Bassi MT, Honda A, Mizuochi T, Kimura A, Nittono H, De Michele G, Carbone R, Criscuolo C, Yau JL, Seckl JR, Schüle R, Schöls L, Sailer AW, Kuhle J, Fraidakis MJ, Gustafsson JÅ, Steffensen KR, Björkhem I, Ernfors P, Sjövall J, Arenas E, Wang Y.

J Clin Invest. 2014 Nov;124(11):4829-42. doi: 10.1172/JCI68506. Epub 2014 Oct 1.

8.

Epigenomic profiling of men exposed to early-life stress reveals DNA methylation differences in association with current mental state.

Khulan B, Manning JR, Dunbar DR, Seckl JR, Raikkonen K, Eriksson JG, Drake AJ.

Transl Psychiatry. 2014 Sep 23;4:e448. doi: 10.1038/tp.2014.94.

9.

Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice.

Yau JL, Wheelan N, Noble J, Walker BR, Webster SP, Kenyon CJ, Ludwig M, Seckl JR.

Neurobiol Aging. 2015 Jan;36(1):334-43. doi: 10.1016/j.neurobiolaging.2014.07.007. Epub 2014 Jul 15.

PMID:
25109766
10.

Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life.

King V, Norman JE, Seckl JR, Drake AJ.

Reprod Biol Endocrinol. 2014 Aug 1;12:73. doi: 10.1186/1477-7827-12-73.

11.

Increased maternal BMI is associated with infant wheezing in early life: a prospective cohort study.

de Vries A, Reynolds RM, Seckl JR, van der Wal M, Bonsel GJ, Vrijkotte TG.

J Dev Orig Health Dis. 2014 Jun 25:1-10. [Epub ahead of print]

PMID:
25081820
12.

Elevation of 11β-hydroxysteroid dehydrogenase type 2 activity in Holocaust survivor offspring: evidence for an intergenerational effect of maternal trauma exposure.

Bierer LM, Bader HN, Daskalakis NP, Lehrner AL, Makotkine I, Seckl JR, Yehuda R.

Psychoneuroendocrinology. 2014 Oct;48:1-10. doi: 10.1016/j.psyneuen.2014.06.001. Epub 2014 Jun 7.

PMID:
24971590
13.

Glucocorticoid receptor gene expression in adipose tissue and associated metabolic risk in black and white South African women.

Goedecke JH, Chorell E, Livingstone DE, Stimson RH, Hayes P, Adams K, Dave JA, Victor H, Levitt NS, Kahn SE, Seckl JR, Walker BR, Olsson T.

Int J Obes (Lond). 2015 Feb;39(2):303-11. doi: 10.1038/ijo.2014.94. Epub 2014 May 20.

PMID:
24854429
14.

24S,25-Epoxycholesterol in mouse and rat brain.

Wang Y, Karu K, Meljon A, Turton J, Yau JL, Seckl JR, Wang Y, Griffiths WJ.

Biochem Biophys Res Commun. 2014 Jun 27;449(2):229-34. doi: 10.1016/j.bbrc.2014.05.012. Epub 2014 May 14.

15.

Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia.

Chapagain A, Caton PW, Kieswich J, Andrikopoulos P, Nayuni N, Long JH, Harwood SM, Webster SP, Raftery MJ, Thiemermann C, Walker BR, Seckl JR, Corder R, Yaqoob MM.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3817-22. doi: 10.1073/pnas.1312436111. Epub 2014 Feb 25.

16.

Inhibiting 11β-hydroxysteroid dehydrogenase type 1 prevents stress effects on hippocampal synaptic plasticity and impairs contextual fear conditioning.

Sarabdjitsingh RA, Zhou M, Yau JL, Webster SP, Walker BR, Seckl JR, Joëls M, Krugers HJ.

Neuropharmacology. 2014 Jun;81:231-6. doi: 10.1016/j.neuropharm.2014.01.042. Epub 2014 Feb 1.

PMID:
24495397
17.

Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas.

Issler O, Carter RN, Paul ED, Kelly PA, Olverman HJ, Neufeld-Cohen A, Kuperman Y, Lowry CA, Seckl JR, Chen A, Jamieson PM.

Biol Mood Anxiety Disord. 2014 Jan 21;4(1):1. doi: 10.1186/2045-5380-4-1.

18.

Associations between maternal level of education and occupational status with placental glucocorticoid regeneration and sensitivity.

Räikkönen K, O'Reilly JR, Pesonen AK, Kajantie E, Villa P, Laivuori H, Hämäläinen E, Seckl JR, Reynolds RM.

Clin Endocrinol (Oxf). 2014 Aug;81(2):175-82. doi: 10.1111/cen.12412. Epub 2014 Feb 13.

PMID:
24443823
19.

Foetal and placental 11β-HSD2: a hub for developmental programming.

Cottrell EC, Seckl JR, Holmes MC, Wyrwoll CS.

Acta Physiol (Oxf). 2014 Feb;210(2):288-95. doi: 10.1111/apha.12187. Epub 2013 Dec 12.

PMID:
24330050
20.

Proinflammatory cytokine induction of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in human adipocytes is mediated by MEK, C/EBPβ, and NF-κB/RelA.

Esteves CL, Kelly V, Breton A, Taylor AI, West CC, Donadeu FX, Péault B, Seckl JR, Chapman KE.

J Clin Endocrinol Metab. 2014 Jan;99(1):E160-8. doi: 10.1210/jc.2013-1708. Epub 2013 Dec 20.

PMID:
24243637
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