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Results: 1 to 20 of 235

1.

Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases.

Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C, Ripke S, Bulik-Sullivan B, Stahl E; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M, Pasaniuc B, Sullivan PF, Neale BM, Wray NR, Raychaudhuri S, Price AL; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium.

Am J Hum Genet. 2014 Nov 6;95(5):535-52. doi: 10.1016/j.ajhg.2014.10.004. Epub 2014 Nov 6.

PMID:
25439723
[PubMed - in process]
2.

Biological insights from 108 schizophrenia-associated genetic loci.

Schizophrenia Working Group of the Psychiatric Genomics Consortium.

Nature. 2014 Jul 24;511(7510):421-7. doi: 10.1038/nature13595. Epub 2014 Jul 22.

PMID:
25056061
[PubMed - indexed for MEDLINE]
3.

Identification of pathways for bipolar disorder: a meta-analysis.

Nurnberger JI Jr, Koller DL, Jung J, Edenberg HJ, Foroud T, Guella I, Vawter MP, Kelsoe JR; Psychiatric Genomics Consortium Bipolar Group.

JAMA Psychiatry. 2014 Jun;71(6):657-64. doi: 10.1001/jamapsychiatry.2014.176.

PMID:
24718920
[PubMed - indexed for MEDLINE]
4.

A polygenic burden of rare disruptive mutations in schizophrenia.

Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, O'Dushlaine C, Chambert K, Bergen SE, Kähler A, Duncan L, Stahl E, Genovese G, Fernández E, Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E, Shakir K, Garimella K, Fennell T, DePristo M, Grant SG, Haggarty SJ, Gabriel S, Scolnick EM, Lander ES, Hultman CM, Sullivan PF, McCarroll SA, Sklar P.

Nature. 2014 Feb 13;506(7487):185-90. doi: 10.1038/nature12975. Epub 2014 Jan 22.

PMID:
24463508
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

De novo mutations in schizophrenia implicate synaptic networks.

Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, Carrera N, Humphreys I, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Grant SG, Hannon E, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Kirov G, Palotie A, McCarroll SA, Holmans P, Sklar P, Owen MJ, Purcell SM, O'Donovan MC.

Nature. 2014 Feb 13;506(7487):179-84. doi: 10.1038/nature12929. Epub 2014 Jan 22.

PMID:
24463507
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Comorbidity of severe psychotic disorders with measures of substance use.

Hartz SM, Pato CN, Medeiros H, Cavazos-Rehg P, Sobell JL, Knowles JA, Bierut LJ, Pato MT; Genomic Psychiatry Cohort Consortium.

JAMA Psychiatry. 2014 Mar;71(3):248-54. doi: 10.1001/jamapsychiatry.2013.3726.

PMID:
24382686
[PubMed - indexed for MEDLINE]
7.

Validating therapeutic targets through human genetics.

Plenge RM, Scolnick EM, Altshuler D.

Nat Rev Drug Discov. 2013 Aug;12(8):581-94. doi: 10.1038/nrd4051. Epub 2013 Jul 19. Review.

PMID:
23868113
[PubMed - indexed for MEDLINE]
8.

Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia.

Jia P, Wang L, Fanous AH, Pato CN, Edwards TL; International Schizophrenia Consortium, Zhao Z.

PLoS Comput Biol. 2012;8(7):e1002587. doi: 10.1371/journal.pcbi.1002587. Epub 2012 Jul 5.

PMID:
22792057
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.

Bergen SE, O'Dushlaine CT, Ripke S, Lee PH, Ruderfer DM, Akterin S, Moran JL, Chambert KD, Handsaker RE, Backlund L, Ösby U, McCarroll S, Landen M, Scolnick EM, Magnusson PK, Lichtenstein P, Hultman CM, Purcell SM, Sklar P, Sullivan PF.

Mol Psychiatry. 2012 Sep;17(9):880-6. doi: 10.1038/mp.2012.73. Epub 2012 Jun 12.

PMID:
22688191
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia.

Jia P, Wang L, Fanous AH, Chen X, Kendler KS; International Schizophrenia Consortium, Zhao Z.

J Med Genet. 2012 Feb;49(2):96-103. doi: 10.1136/jmedgenet-2011-100397. Epub 2011 Dec 20.

PMID:
22187495
[PubMed - indexed for MEDLINE]
11.

Advancing drug discovery for schizophrenia.

Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, Law AJ, Campbell B, Krystal JH, Moghaddam B, Sawa A, Caron MG, George SR, Allen JA, Solis M.

Ann N Y Acad Sci. 2011 Oct;1236:30-43. doi: 10.1111/j.1749-6632.2011.06216.x. Erratum in: Ann N Y Acad Sci. 2012 Jul;1259:145. Saw, Akira [corrected to Sawa, Akira].

PMID:
22032400
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.

Kuai L, Ong SE, Madison JM, Wang X, Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, Haggarty SJ.

Chem Biol. 2011 Jul 29;18(7):891-906. doi: 10.1016/j.chembiol.2011.03.017.

PMID:
21802010
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia.

Chen J, Lee G, Fanous AH, Zhao Z, Jia P, O'Neill A, Walsh D, Kendler KS, Chen X; International Schizophrenia Consortium.

Schizophr Res. 2011 Sep;131(1-3):43-51. doi: 10.1016/j.schres.2011.06.023. Epub 2011 Jul 14.

PMID:
21752600
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Genetic classification of populations using supervised learning.

Bridges M, Heron EA, O'Dushlaine C, Segurado R; International Schizophrenia Consortium (ISC), Morris D, Corvin A, Gill M, Pinto C.

PLoS One. 2011 May 12;6(5):e14802. doi: 10.1371/journal.pone.0014802.

PMID:
21589856
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.

Pan JQ, Lewis MC, Ketterman JK, Clore EL, Riley M, Richards KR, Berry-Scott E, Liu X, Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, Haggarty SJ.

Neuropsychopharmacology. 2011 Jun;36(7):1397-411. doi: 10.1038/npp.2011.24. Epub 2011 Mar 9.

PMID:
21389981
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain.

Richards AL, Jones L, Moskvina V, Kirov G, Gejman PV, Levinson DF, Sanders AR; Molecular Genetics of Schizophrenia Collaboration (MGS); International Schizophrenia Consortium (ISC), Purcell S, Visscher PM, Craddock N, Owen MJ, Holmans P, O'Donovan MC.

Mol Psychiatry. 2012 Feb;17(2):193-201. doi: 10.1038/mp.2011.11. Epub 2011 Feb 22.

PMID:
21339752
[PubMed - indexed for MEDLINE]
17.

GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.

Chen X, Lee G, Maher BS, Fanous AH, Chen J, Zhao Z, Guo A, van den Oord E, Sullivan PF, Shi J, Levinson DF, Gejman PV, Sanders A, Duan J, Owen MJ, Craddock NJ, O'Donovan MC, Blackman J, Lewis D, Kirov GK, Qin W, Schwab S, Wildenauer D, Chowdari K, Nimgaonkar V, Straub RE, Weinberger DR, O'Neill FA, Walsh D, Bronstein M, Darvasi A, Lencz T, Malhotra AK, Rujescu D, Giegling I, Werge T, Hansen T, Ingason A, Nöethen MM, Rietschel M, Cichon S, Djurovic S, Andreassen OA, Cantor RM, Ophoff R, Corvin A, Morris DW, Gill M, Pato CN, Pato MT, Macedo A, Gurling HM, McQuillin A, Pimm J, Hultman C, Lichtenstein P, Sklar P, Purcell SM, Scolnick E, St Clair D, Blackwood DH, Kendler KS; GROUP investigators; International Schizophrenia Consortium.

Mol Psychiatry. 2011 Nov;16(11):1117-29. doi: 10.1038/mp.2010.96. Epub 2010 Sep 14.

PMID:
20838396
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling.

Kuai L, Wang X, Madison JM, Schreiber SL, Scolnick EM, Haggarty SJ.

ACS Chem Neurosci. 2010 Jan 28;1(4):325-342.

PMID:
20495671
[PubMed]
Free PMC Article
19.

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.

Liu Y, Blackwood DH, Caesar S, de Geus EJ, Farmer A, Ferreira MA, Ferrier IN, Fraser C, Gordon-Smith K, Green EK, Grozeva D, Gurling HM, Hamshere ML, Heutink P, Holmans PA, Hoogendijk WJ, Hottenga JJ, Jones L, Jones IR, Kirov G, Lin D, McGuffin P, Moskvina V, Nolen WA, Perlis RH, Posthuma D, Scolnick EM, Smit AB, Smit JH, Smoller JW, St Clair D, van Dyck R, Verhage M, Willemsen G, Young AH, Zandbelt T, Boomsma DI, Craddock N, O'Donovan MC, Owen MJ, Penninx BW, Purcell S, Sklar P, Sullivan PF; Wellcome Trust Case-Control Consortium.

Mol Psychiatry. 2011 Jan;16(1):2-4. doi: 10.1038/mp.2009.107. Epub 2010 Mar 30. No abstract available.

PMID:
20351715
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility.

O'Dushlaine C, Kenny E, Heron E, Donohoe G, Gill M, Morris D; International Schizophrenia Consortium, Corvin A.

Mol Psychiatry. 2011 Mar;16(3):286-92. doi: 10.1038/mp.2010.7. Epub 2010 Feb 16.

PMID:
20157312
[PubMed - indexed for MEDLINE]

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