The meta-analysis results show that, compared to the placebo, probiotics significantly improved stool consistency (MD = 0.72, 95% CI (0.18, 1.26), p < 0.05, low quality) and increased the number of fecal Bifidobacteria (MD = 1.75, 95% CI (1.51, 2.00), p < 0.05, low quality)
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The meta-analysis results showed that, compared to the placebo, probiotics therapy significantly decreased the score of IBS-D symptoms (SMD = - 0.55, 95% CI: [- 0.83, - 0.27], P < 0.05), abdominal pain (SMD = - 0.43, 95% CI: [- 0.57, - 0.29], P < 0.05), and abdominal
…For the supplement users (n = 333; 82.8%), a median ProMAS sum score of 11.0 (7.0-15.0) was observed. Increasing age and medicine intake were positive predictors of compliance (age: B = 0.058, p = 0.01; medicine intake: B = 0.39, p < 0.001), while experiencing barriers
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