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Results: 1 to 20 of 57

1.

Interaction of cCMP with the cGK, cAK and MAPK Kinases in Murine Tissues.

Wolfertstetter S, Reinders J, Schwede F, Ruth P, Schinner E, Schlossmann J.

PLoS One. 2015 May 15;10(5):e0126057. doi: 10.1371/journal.pone.0126057. eCollection 2015.

2.

Structure-guided design of selective Epac1 and Epac2 agonists.

Schwede F, Bertinetti D, Langerijs CN, Hadders MA, Wienk H, Ellenbroek JH, de Koning EJ, Bos JL, Herberg FW, Genieser HG, Janssen RA, Rehmann H.

PLoS Biol. 2015 Jan 20;13(1):e1002038. doi: 10.1371/journal.pbio.1002038. eCollection 2015 Jan.

3.

Identification, characterization, and structure analysis of the cyclic di-AMP-binding PII-like signal transduction protein DarA.

Gundlach J, Dickmanns A, Schröder-Tittmann K, Neumann P, Kaesler J, Kampf J, Herzberg C, Hammer E, Schwede F, Kaever V, Tittmann K, Stülke J, Ficner R.

J Biol Chem. 2015 Jan 30;290(5):3069-80. doi: 10.1074/jbc.M114.619619. Epub 2014 Nov 28.

PMID:
25433025
4.

N4-monobutyryl-cCMP activates PKA RIα and PKA RIIα more potently and with higher efficacy than PKG Iα in vitro but not in vivo.

Wolter S, Dove S, Golombek M, Schwede F, Seifert R.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Dec;387(12):1163-75. doi: 10.1007/s00210-014-1042-9. Epub 2014 Sep 6.

PMID:
25192685
5.

cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects.

Beckert U, Grundmann M, Wolter S, Schwede F, Rehmann H, Kaever V, Kostenis E, Seifert R.

Biochem Biophys Res Commun. 2014 Sep 5;451(4):497-502. doi: 10.1016/j.bbrc.2014.07.134. Epub 2014 Aug 7.

PMID:
25108158
6.

Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.

Lolicato M, Bucchi A, Arrigoni C, Zucca S, Nardini M, Schroeder I, Simmons K, Aquila M, DiFrancesco D, Bolognesi M, Schwede F, Kashin D, Fishwick CW, Johnson AP, Thiel G, Moroni A.

Nat Chem Biol. 2014 Jun;10(6):457-62. doi: 10.1038/nchembio.1521. Epub 2014 Apr 28. Erratum in: Nat Chem Biol. 2014 Aug;10(8):692.

PMID:
24776929
7.

Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.

Herfindal L, Krakstad C, Myhren L, Hagland H, Kopperud R, Teigen K, Schwede F, Kleppe R, Døskeland SO.

PLoS One. 2014 Apr 16;9(4):e94926. doi: 10.1371/journal.pone.0094926. eCollection 2014.

8.

Cyclic nucleotide mapping of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

Möller S, Alfieri A, Bertinetti D, Aquila M, Schwede F, Lolicato M, Rehmann H, Moroni A, Herberg FW.

ACS Chem Biol. 2014 May 16;9(5):1128-37. doi: 10.1021/cb400904s. Epub 2014 Mar 7.

PMID:
24605759
9.

Epac-Rap signaling reduces oxidative stress in the tubular epithelium.

Stokman G, Qin Y, Booij TH, Ramaiahgari S, Lacombe M, Dolman ME, van Dorenmalen KM, Teske GJ, Florquin S, Schwede F, van de Water B, Kok RJ, Price LS.

J Am Soc Nephrol. 2014 Jul;25(7):1474-85. doi: 10.1681/ASN.2013070679. Epub 2014 Feb 7.

PMID:
24511123
10.

Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.

Chepurny OG, Bertinetti D, Diskar M, Leech CA, Afshari P, Tsalkova T, Cheng X, Schwede F, Genieser HG, Herberg FW, Holz GG.

Mol Endocrinol. 2013 Aug;27(8):1267-82. doi: 10.1210/me.2013-1029. Epub 2013 Jun 24.

11.

Dissociations in the effects of β2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: support for the concept of functional selectivity.

Brunskole Hummel I, Reinartz MT, Kälble S, Burhenne H, Schwede F, Buschauer A, Seifert R.

PLoS One. 2013 May 31;8(5):e64556. doi: 10.1371/journal.pone.0064556. Print 2013.

12.

Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis.

Gausdal G, Wergeland A, Skavland J, Nguyen E, Pendino F, Rouhee N, McCormack E, Herfindal L, Kleppe R, Havemann U, Schwede F, Bruserud O, Gjertsen BT, Lanotte M, Ségal-Bendirdjian E, Døskeland SO.

Cell Death Dis. 2013 Feb 28;4:e516. doi: 10.1038/cddis.2013.39.

13.
14.

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.

Almahariq M, Tsalkova T, Mei FC, Chen H, Zhou J, Sastry SK, Schwede F, Cheng X.

Mol Pharmacol. 2013 Jan;83(1):122-8. doi: 10.1124/mol.112.080689. Epub 2012 Oct 11.

15.

Binding of regulatory subunits of cyclic AMP-dependent protein kinase to cyclic CMP agarose.

Hammerschmidt A, Chatterji B, Zeiser J, Schröder A, Genieser HG, Pich A, Kaever V, Schwede F, Wolter S, Seifert R.

PLoS One. 2012;7(7):e39848. doi: 10.1371/journal.pone.0039848. Epub 2012 Jul 9.

16.

Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels.

Nache V, Zimmer T, Wongsamitkul N, Schmauder R, Kusch J, Reinhardt L, Bönigk W, Seifert R, Biskup C, Schwede F, Benndorf K.

Sci Signal. 2012 Jul 10;5(232):ra48. doi: 10.1126/scisignal.2003110.

17.

How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels.

Kusch J, Thon S, Schulz E, Biskup C, Nache V, Zimmer T, Seifert R, Schwede F, Benndorf K.

Nat Chem Biol. 2011 Dec 18;8(2):162-9. doi: 10.1038/nchembio.747.

PMID:
22179066
18.

A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa.

Düvel J, Bertinetti D, Möller S, Schwede F, Morr M, Wissing J, Radamm L, Zimmermann B, Genieser HG, Jänsch L, Herberg FW, Häussler S.

J Microbiol Methods. 2012 Feb;88(2):229-36. doi: 10.1016/j.mimet.2011.11.015. Epub 2011 Dec 8.

PMID:
22178430
19.

Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription.

Huseby S, Gausdal G, Keen TJ, Kjærland E, Krakstad C, Myhren L, Brønstad K, Kunick C, Schwede F, Genieser HG, Kleppe R, Døskeland SO.

Cell Death Dis. 2011 Dec 8;2:e237. doi: 10.1038/cddis.2011.124.

20.

Activation of PDE10 and PDE11 phosphodiesterases.

Jäger R, Russwurm C, Schwede F, Genieser HG, Koesling D, Russwurm M.

J Biol Chem. 2012 Jan 6;287(2):1210-9. doi: 10.1074/jbc.M111.263806. Epub 2011 Nov 21.

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