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Complement factor H in its alternative identity as adrenomedullin-binding protein 1.

Sim RB, Ferluga J, Al-Rashidi H, Abbow H, Schwaeble W, Kishore U.

Mol Immunol. 2015 Nov;68(1):45-8. doi: 10.1016/j.molimm.2015.06.006.


Further studies of the down-regulation by Factor I of the C3b feedback cycle using endotoxin as a soluble activator and red cells as a source of CR1 on sera of different complotype.

Lachmann PJ, Lay E, Seilly DJ, Buchberger A, Schwaeble W, Khadake J.

Clin Exp Immunol. 2015 Sep 28. doi: 10.1111/cei.12714. [Epub ahead of print]


Properdin Regulation of Complement Activation Affects Colitis in Interleukin 10 Gene-Deficient Mice.

Jain U, Midgen CA, Schwaeble WJ, Stover CM, Stadnyk AW.

Inflamm Bowel Dis. 2015 Jul;21(7):1519-28. doi: 10.1097/MIB.0000000000000398.


Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome.

Venkatraman Girija U, Furze CM, Gingras AR, Yoshizaki T, Ohtani K, Marshall JE, Wallis AK, Schwaeble WJ, El-Mezgueldi M, Mitchell DA, Moody PC, Wakamiya N, Wallis R.

BMC Biol. 2015 Apr 17;13:27. doi: 10.1186/s12915-015-0136-2.


Properdin provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6-dependent manner.

Jain U, Cao Q, Thomas NA, Woodruff TM, Schwaeble WJ, Stover CM, Stadnyk AW.

J Immunol. 2015 Apr 1;194(7):3414-21. doi: 10.4049/jimmunol.1401814. Epub 2015 Feb 27.


Deficiency in mannose-binding lectin-associated serine protease-2 does not increase susceptibility to Trypanosoma cruzi infection.

Ribeiro CH, Lynch NJ, Stover CM, Ali YM, Valck C, Noya-Leal F, Schwaeble WJ, Ferreira A.

Am J Trop Med Hyg. 2015 Feb;92(2):320-4. doi: 10.4269/ajtmh.14-0236. Epub 2014 Dec 29.


Complotype affects the extent of down-regulation by Factor I of the C3b feedback cycle in vitro.

Lay E, Nutland S, Smith JE, Hiles I, Smith RA, Seilly DJ, Buchberger A, Schwaeble W, Lachmann PJ.

Clin Exp Immunol. 2015 Aug;181(2):314-22. doi: 10.1111/cei.12437.


Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4.

Asgari E, Farrar CA, Lynch N, Ali YM, Roscher S, Stover C, Zhou W, Schwaeble WJ, Sacks SH.

FASEB J. 2014 Sep;28(9):3996-4003. doi: 10.1096/fj.13-246306. Epub 2014 May 27.


Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin.

Sosoniuk E, Vallejos G, Kenawy H, Gaboriaud C, Thielens N, Fujita T, Schwaeble W, Ferreira A, Valck C.

Mol Immunol. 2014 Jul;60(1):80-5. doi: 10.1016/j.molimm.2014.03.014. Epub 2014 Apr 24.


Septicaemia models using Streptococcus pneumoniae and Listeria monocytogenes: understanding the role of complement properdin.

Dupont A, Mohamed F, Salehen N, Glenn S, Francescut L, Adib R, Byrne S, Brewin H, Elliott I, Richards L, Dimitrova P, Schwaeble W, Ivanovska N, Kadioglu A, Machado LR, Andrew PW, Stover C.

Med Microbiol Immunol. 2014 Aug;203(4):257-71. doi: 10.1007/s00430-013-0324-z. Epub 2014 Apr 12.


Low-dose recombinant properdin provides substantial protection against Streptococcus pneumoniae and Neisseria meningitidis infection.

Ali YM, Hayat A, Saeed BM, Haleem KS, Alshamrani S, Kenawy HI, Ferreira VP, Saggu G, Buchberger A, Lachmann PJ, Sim RB, Goundis D, Andrew PW, Lynch NJ, Schwaeble WJ.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5301-6. doi: 10.1073/pnas.1401011111. Epub 2014 Mar 24.


Human L-ficolin, a recognition molecule of the lectin activation pathway of complement, activates complement by binding to pneumolysin, the major toxin of Streptococcus pneumoniae.

Ali YM, Kenawy HI, Muhammad A, Sim RB, Andrew PW, Schwaeble WJ.

PLoS One. 2013 Dec 12;8(12):e82583. doi: 10.1371/journal.pone.0082583. eCollection 2013.


Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation.

Venkatraman Girija U, Gingras AR, Marshall JE, Panchal R, Sheikh MA, Gál P, Schwaeble WJ, Mitchell DA, Moody PC, Wallis R.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13916-20. doi: 10.1073/pnas.1311113110. Epub 2013 Aug 6.


Role of ficolin-A and lectin complement pathway in the innate defense against pathogenic Aspergillus species.

Bidula S, Kenawy H, Ali YM, Sexton D, Schwaeble WJ, Schelenz S.

Infect Immun. 2013 May;81(5):1730-40. doi: 10.1128/IAI.00032-13. Epub 2013 Mar 11.


Targeting complement at the time of transplantation.

Sacks S, Karegli J, Farrar CA, Asgari E, Schwaeble W, Zhou W, Smith RA.

Adv Exp Med Biol. 2013;735:247-55. Review.


Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency.

Ruseva MM, Vernon KA, Lesher AM, Schwaeble WJ, Ali YM, Botto M, Cook T, Song W, Stover CM, Pickering MC.

J Am Soc Nephrol. 2013 Jan;24(1):43-52. doi: 10.1681/ASN.2012060571. Epub 2012 Nov 26.


Which pathways trigger the role of complement in ischaemia/reperfusion injury?

Farrar CA, Asgari E, Schwaeble WJ, Sacks SH.

Front Immunol. 2012 Nov 19;3:341. doi: 10.3389/fimmu.2012.00341. eCollection 2012.


Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection.

Endo Y, Takahashi M, Iwaki D, Ishida Y, Nakazawa N, Kodama T, Matsuzaka T, Kanno K, Liu Y, Tsuchiya K, Kawamura I, Ikawa M, Waguri S, Wada I, Matsushita M, Schwaeble WJ, Fujita T.

J Immunol. 2012 Dec 15;189(12):5860-6. doi: 10.4049/jimmunol.1200836. Epub 2012 Nov 12.


The complement system in ischemia-reperfusion injuries.

Gorsuch WB, Chrysanthou E, Schwaeble WJ, Stahl GL.

Immunobiology. 2012 Nov;217(11):1026-33. doi: 10.1016/j.imbio.2012.07.024. Epub 2012 Aug 7. Review.


Abrogated RANKL expression in properdin-deficient mice is associated with better outcome from collagen-antibody-induced arthritis.

Dimitrova P, Ivanovska N, Belenska L, Milanova V, Schwaeble W, Stover C.

Arthritis Res Ther. 2012 Jul 25;14(4):R173. doi: 10.1186/ar3926.

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