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A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions.

Schuster S, Roessler C, Meleshin M, Zimmermann P, Simic Z, Kambach C, Schiene-Fischer C, Steegborn C, Hottiger MO, Schutkowski M.

Sci Rep. 2016 Mar 4;6:22643. doi: 10.1038/srep22643.


PKC-Theta is a Novel SC35 Splicing Factor Regulator in Response to T Cell Activation.

McCuaig RD, Dunn J, Li J, Masch A, Knaute T, Schutkowski M, Zerweck J, Rao S.

Front Immunol. 2015 Nov 5;6:562. doi: 10.3389/fimmu.2015.00562. eCollection 2015.


The ɛ-Amino Group of Protein Lysine Residues Is Highly Susceptible to Nonenzymatic Acylation by Several Physiological Acyl-CoA Thioesters.

Simic Z, Weiwad M, Schierhorn A, Steegborn C, Schutkowski M.

Chembiochem. 2015 Nov 2;16(16):2337-47. doi: 10.1002/cbic.201500364. Epub 2015 Sep 18.


A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases.

Roessler C, Tüting C, Meleshin M, Steegborn C, Schutkowski M.

J Med Chem. 2015 Sep 24;58(18):7217-23. doi: 10.1021/acs.jmedchem.5b00293. Epub 2015 Sep 8.


Identification of peptidic substrates for the human kinase Myt1 using peptide microarrays.

Rohe A, Platzer C, Masch A, Greiner S, Henze C, Ihling C, Erdmann F, Schutkowski M, Sippl W, Schmidt M.

Bioorg Med Chem. 2015 Aug 1;23(15):4936-42. doi: 10.1016/j.bmc.2015.05.021. Epub 2015 May 19.


SIRT5 regulation of ammonia-induced autophagy and mitophagy.

Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, Steegborn C, Nowak T, Schutkowski M, Pellegrini L, Sansone L, Villanova L, Runci A, Pucci B, Morgante E, Fini M, Mai A, Russo MA, Tafani M.

Autophagy. 2015;11(2):253-70. doi: 10.1080/15548627.2015.1009778.


Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M.

Nat Commun. 2015 Feb 12;6:6263. doi: 10.1038/ncomms7263.


The peptide microarray "ChloroPhos1.0" identifies new phosphorylation targets of plastid casein kinase II (pCKII) in Arabidopsis thaliana.

Schönberg A, Bergner E, Helm S, Agne B, Dünschede B, Schünemann D, Schutkowski M, Baginsky S.

PLoS One. 2014 Oct 8;9(10):e108344. doi: 10.1371/journal.pone.0108344. eCollection 2014.


Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors.

Roessler C, Nowak T, Pannek M, Gertz M, Nguyen GT, Scharfe M, Born I, Sippl W, Steegborn C, Schutkowski M.

Angew Chem Int Ed Engl. 2014 Sep 26;53(40):10728-32. doi: 10.1002/anie.201402679. Epub 2014 Aug 11.


Whole CMV proteome pattern recognition analysis after HSCT identifies unique epitope targets associated with the CMV status.

Pérez-Bercoff L, Valentini D, Gaseitsiwe S, Mahdavifar S, Schutkowski M, Poiret T, Pérez-Bercoff Å, Ljungman P, Maeurer MJ.

PLoS One. 2014 Apr 16;9(4):e89648. doi: 10.1371/journal.pone.0089648. eCollection 2014.


New assays and approaches for discovery and design of Sirtuin modulators.

Schutkowski M, Fischer F, Roessler C, Steegborn C.

Expert Opin Drug Discov. 2014 Feb;9(2):183-99. doi: 10.1517/17460441.2014.875526. Epub 2014 Jan 2. Review.


Serotyping of Toxoplasma gondii in cats (Felis domesticus) reveals predominance of type II infections in Germany.

Maksimov P, Zerweck J, Dubey JP, Pantchev N, Frey CF, Maksimov A, Reimer U, Schutkowski M, Hosseininejad M, Ziller M, Conraths FJ, Schares G.

PLoS One. 2013 Nov 7;8(11):e80213. doi: 10.1371/journal.pone.0080213. eCollection 2013.


An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms.

Rauh D, Fischer F, Gertz M, Lakshminarasimhan M, Bergbrede T, Aladini F, Kambach C, Becker CF, Zerweck J, Schutkowski M, Steegborn C.

Nat Commun. 2013;4:2327. doi: 10.1038/ncomms3327.


Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.

Gertz M, Fischer F, Nguyen GT, Lakshminarasimhan M, Schutkowski M, Weyand M, Steegborn C.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2772-81. doi: 10.1073/pnas.1303628110. Epub 2013 Jul 9.


The SH2 domain interaction landscape.

Tinti M, Kiemer L, Costa S, Miller ML, Sacco F, Olsen JV, Carducci M, Paoluzi S, Langone F, Workman CT, Blom N, Machida K, Thompson CM, Schutkowski M, Brunak S, Mann M, Mayer BJ, Castagnoli L, Cesareni G.

Cell Rep. 2013 Apr 25;3(4):1293-305. doi: 10.1016/j.celrep.2013.03.001. Epub 2013 Mar 28.


Sirt1 activation by resveratrol is substrate sequence-selective.

Lakshminarasimhan M, Rauh D, Schutkowski M, Steegborn C.

Aging (Albany NY). 2013 Mar;5(3):151-4.


Identification of prolyl oligopeptidase as a cyclosporine-sensitive protease by screening of mouse liver extracts.

Rentzsch A, Kahlert V, Jahreis G, Schlott B, Schutkowski M, Malešević M, Fischer G.

Biol Chem. 2013 Aug;394(8):1057-67. doi: 10.1515/hsz-2013-0125.


Crystal structure analysis of human Sirt2 and its ADP-ribose complex.

Moniot S, Schutkowski M, Steegborn C.

J Struct Biol. 2013 May;182(2):136-43. doi: 10.1016/j.jsb.2013.02.012. Epub 2013 Feb 26.


Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation.

Wolf A, Rietscher K, Glaß M, Hüttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M.

J Cell Sci. 2013 Apr 15;126(Pt 8):1832-44. doi: 10.1242/jcs.118992. Epub 2013 Feb 26.


Peptide binding by catalytic domains of the protein disulfide isomerase-related protein ERp46.

Funkner A, Parthier C, Schutkowski M, Zerweck J, Lilie H, Gyrych N, Fischer G, Stubbs MT, Ferrari DM.

J Mol Biol. 2013 Apr 26;425(8):1340-62. doi: 10.1016/j.jmb.2013.01.029. Epub 2013 Jan 30.

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