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Items: 1 to 20 of 32

1.

Automated harvesting and 2-step purification of unclarified mammalian cell-culture broths containing antibodies.

Holenstein F, Eriksson C, Erlandsson I, Norrman N, Simon J, Danielsson Å, Milicov A, Schindler P, Schlaeppi JM.

J Chromatogr A. 2015 Oct 30;1418:103-9. doi: 10.1016/j.chroma.2015.09.040. Epub 2015 Sep 18.

2.
3.

Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue.

Chène P, Rudloff J, Schoepfer J, Furet P, Meier P, Qian Z, Schlaeppi JM, Schmitz R, Radimerski T.

BMC Chem Biol. 2009 Jan 7;9:1. doi: 10.1186/1472-6769-9-1.

4.

The guinea-pig tracheal potential difference as an in vivo model for the study of epithelial sodium channel function in the airways.

Coote KJ, Atherton H, Young A, Sugar R, Burrows R, Smith NJ, Schlaeppi JM, Groot-Kormelink PJ, Gosling M, Danahay H.

Br J Pharmacol. 2008 Dec;155(7):1025-33. doi: 10.1038/bjp.2008.363. Epub 2008 Sep 22.

5.

Improved expression of kinases in Baculovirus-infected insect cells upon addition of specific kinase inhibitors to the culture helpful for structural studies.

Strauss A, Fendrich G, Horisberger MA, Liebetanz J, Meyhack B, Schlaeppi JM, Schmitz R.

Protein Expr Purif. 2007 Dec;56(2):167-76. Epub 2007 Jul 10.

PMID:
17720535
6.

Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization.

Fernández-Montalván A, Bouwmeester T, Joberty G, Mader R, Mahnke M, Pierrat B, Schlaeppi JM, Worpenberg S, Gerhartz B.

FEBS J. 2007 Aug;274(16):4256-70. Epub 2007 Jul 25.

7.

Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism.

Kallen J, Lattmann R, Beerli R, Blechschmidt A, Blommers MJ, Geiser M, Ottl J, Schlaeppi JM, Strauss A, Fournier B.

J Biol Chem. 2007 Aug 10;282(32):23231-9. Epub 2007 Jun 6.

8.

A semi-automated large-scale process for the production of recombinant tagged proteins in the Baculovirus expression system.

Schlaeppi JM, Henke M, Mahnke M, Hartmann S, Schmitz R, Pouliquen Y, Kerins B, Weber E, Kolbinger F, Kocher HP.

Protein Expr Purif. 2006 Dec;50(2):185-95. Epub 2006 Jul 4.

PMID:
16904904
9.
10.

Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A.

Kallen J, Schlaeppi JM, Bitsch F, Delhon I, Fournier B.

J Biol Chem. 2004 Apr 2;279(14):14033-8. Epub 2004 Jan 13.

11.

Identification of natural ligands of retinoic acid receptor-related orphan receptor alpha ligand-binding domain expressed in Sf9 cells--a mass spectrometry approach.

Bitsch F, Aichholz R, Kallen J, Geisse S, Fournier B, Schlaeppi JM.

Anal Biochem. 2003 Dec 1;323(1):139-49.

PMID:
14622968
12.

Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands.

Renaud J, Bischoff SF, Buhl T, Floersheim P, Fournier B, Halleux C, Kallen J, Keller H, Schlaeppi JM, Stark W.

J Med Chem. 2003 Jul 3;46(14):2945-57.

PMID:
12825935
13.

X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha.

Kallen JA, Schlaeppi JM, Bitsch F, Geisse S, Geiser M, Delhon I, Fournier B.

Structure. 2002 Dec;10(12):1697-707.

14.

Therapies directed at vascular endothelial growth factor.

Manley PW, Martiny-Baron G, Schlaeppi JM, Wood JM.

Expert Opin Investig Drugs. 2002 Dec;11(12):1715-36. Review.

PMID:
12457433
15.

Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis.

Viloria-Petit A, Crombet T, Jothy S, Hicklin D, Bohlen P, Schlaeppi JM, Rak J, Kerbel RS.

Cancer Res. 2001 Jul 1;61(13):5090-101.

17.

Characterization of a new potent, in vivo neutralizing monoclonal antibody to human vascular endothelial growth factor.

Schlaeppi JM, Siemeister G, Weindel K, Schnell C, Wood J.

J Cancer Res Clin Oncol. 1999;125(6):336-42.

PMID:
10363565
18.

Markers of tumor angiogenesis and proteolysis independently define high- and low-risk subsets of node-negative breast cancer patients.

Eppenberger U, Kueng W, Schlaeppi JM, Roesel JL, Benz C, Mueller H, Matter A, Zuber M, Luescher K, Litschgi M, Schmitt M, Foekens JA, Eppenberger-Castori S.

J Clin Oncol. 1998 Sep;16(9):3129-36.

PMID:
9738585
19.

1,25-Dihydroxyvitamin D3 induces the expression of vascular endothelial growth factor in osteoblastic cells.

Schlaeppi JM, Gutzwiller S, Finkenzeller G, Fournier B.

Endocr Res. 1997 Aug;23(3):213-29.

PMID:
9378108
20.

Chemiluminescence immunoassay for vascular endothelial growth factor (vascular permeability factor) in tumor-tissue homogenates.

Schlaeppi JM, Eppenberger U, Martiny-Baron G, Küng W.

Clin Chem. 1996 Nov;42(11):1777-84.

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