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Results: 1 to 20 of 30

1.

Optimization of 1,2,5-Thiadiazole Carbamates as Potent and Selective ABHD6 Inhibitors.

Patel JZ, Nevalainen TJ, Savinainen JR, Adams Y, Laitinen T, Runyon RS, Vaara M, Ahenkorah S, Kaczor AA, Navia-Paldanius D, Gynther M, Aaltonen N, Joharapurkar AA, Jain MR, Haka AS, Maxfield FR, Laitinen JT, Parkkari T.

ChemMedChem. 2015 Feb;10(2):253-65. doi: 10.1002/cmdc.201402453. Epub 2014 Dec 11.

PMID:
25504894
[PubMed - in process]
2.

Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands.

Bertini S, Parkkari T, Savinainen JR, Arena C, Saccomanni G, Saguto S, Ligresti A, Allarà M, Bruno A, Marinelli L, Di Marzo V, Novellino E, Manera C, Macchia M.

Eur J Med Chem. 2015 Jan 27;90:526-36. doi: 10.1016/j.ejmech.2014.11.066. Epub 2014 Dec 2.

PMID:
25486424
[PubMed - in process]
3.

Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A).

Savinainen JR, Patel JZ, Parkkari T, Navia-Paldanius D, Marjamaa JJ, Laitinen T, Nevalainen T, Laitinen JT.

PLoS One. 2014 Oct 7;9(10):e109869. doi: 10.1371/journal.pone.0109869. eCollection 2014.

PMID:
25290914
[PubMed - in process]
Free PMC Article
4.

Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).

Korhonen J, Kuusisto A, van Bruchem J, Patel JZ, Laitinen T, Navia-Paldanius D, Laitinen JT, Savinainen JR, Parkkari T, Nevalainen TJ.

Bioorg Med Chem. 2014 Dec 1;22(23):6694-705. doi: 10.1016/j.bmc.2014.09.012. Epub 2014 Sep 16.

PMID:
25282655
[PubMed - in process]
5.

Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL).

Savinainen JR, Kansanen E, Pantsar T, Navia-Paldanius D, Parkkari T, Lehtonen M, Laitinen T, Nevalainen T, Poso A, Levonen AL, Laitinen JT.

Mol Pharmacol. 2014 Nov;86(5):522-35. doi: 10.1124/mol.114.094284. Epub 2014 Aug 19.

PMID:
25140003
[PubMed - indexed for MEDLINE]
6.

Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12).

Parkkari T, Haavikko R, Laitinen T, Navia-Paldanius D, Rytilahti R, Vaara M, Lehtonen M, Alakurtti S, Yli-Kauhaluoma J, Nevalainen T, Savinainen JR, Laitinen JT.

PLoS One. 2014 May 30;9(5):e98286. doi: 10.1371/journal.pone.0098286. eCollection 2014.

PMID:
24879289
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor.

Lucchesi V, Parkkari T, Savinainen JR, Malfitano AM, Allarà M, Bertini S, Castelli F, Del Carlo S, Laezza C, Ligresti A, Saccomanni G, Bifulco M, Di Marzo V, Macchia M, Manera C.

Eur J Med Chem. 2014 Mar 3;74:524-32. doi: 10.1016/j.ejmech.2013.10.070. Epub 2014 Jan 21.

PMID:
24518874
[PubMed - indexed for MEDLINE]
8.

Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency.

Laitinen T, Navia-Paldanius D, Rytilahti R, Marjamaa JJ, Kařízková J, Parkkari T, Pantsar T, Poso A, Laitinen JT, Savinainen JR.

Mol Pharmacol. 2014 Mar;85(3):510-9. doi: 10.1124/mol.113.090795. Epub 2013 Dec 24.

PMID:
24368842
[PubMed - indexed for MEDLINE]
9.

Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.

Patel JZ, Parkkari T, Laitinen T, Kaczor AA, Saario SM, Savinainen JR, Navia-Paldanius D, Cipriano M, Leppänen J, Koshevoy IO, Poso A, Fowler CJ, Laitinen JT, Nevalainen T.

J Med Chem. 2013 Nov 14;56(21):8484-96. doi: 10.1021/jm400923s. Epub 2013 Oct 22.

PMID:
24083878
[PubMed - indexed for MEDLINE]
10.

Brain regional cannabinoid CB(1) receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice.

Aaltonen N, Riera Ribas C, Lehtonen M, Savinainen JR, Laitinen JT.

Eur J Pharm Sci. 2014 Jan 23;51:87-95. doi: 10.1016/j.ejps.2013.08.035. Epub 2013 Sep 3.

PMID:
24012970
[PubMed - indexed for MEDLINE]
11.

Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.

Aaltonen N, Savinainen JR, Ribas CR, Rönkkö J, Kuusisto A, Korhonen J, Navia-Paldanius D, Häyrinen J, Takabe P, Käsnänen H, Pantsar T, Laitinen T, Lehtonen M, Pasonen-Seppänen S, Poso A, Nevalainen T, Laitinen JT.

Chem Biol. 2013 Mar 21;20(3):379-90. doi: 10.1016/j.chembiol.2013.01.012.

PMID:
23521796
[PubMed - indexed for MEDLINE]
Free Article
12.

Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).

Navia-Paldanius D, Savinainen JR, Laitinen JT.

J Lipid Res. 2012 Nov;53(11):2413-24. doi: 10.1194/jlr.M030411. Epub 2012 Sep 11.

PMID:
22969151
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors.

Savinainen JR, Saario SM, Laitinen JT.

Acta Physiol (Oxf). 2012 Feb;204(2):267-76. doi: 10.1111/j.1748-1716.2011.02280.x. Epub 2011 Apr 22. Review. Erratum in: Acta Physiol (Oxf). 2012 Mar;204(3):460.

PMID:
21418147
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique.

Savinainen JR, Yoshino M, Minkkilä A, Nevalainen T, Laitinen JT.

Anal Biochem. 2010 Apr 1;399(1):132-4. doi: 10.1016/j.ab.2009.12.009. Epub 2009 Dec 11.

PMID:
20005861
[PubMed - indexed for MEDLINE]
15.

Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors.

Minkkilä A, Savinainen JR, Käsnänen H, Xhaard H, Nevalainen T, Laitinen JT, Poso A, Leppänen J, Saario SM.

ChemMedChem. 2009 Aug;4(8):1253-9. doi: 10.1002/cmdc.200900137. No abstract available.

PMID:
19472270
[PubMed - indexed for MEDLINE]
16.

Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography.

Palomäki VA, Lehtonen M, Savinainen JR, Laitinen JT.

J Neurochem. 2007 May;101(4):972-81. Epub 2007 Jan 24.

PMID:
17254014
[PubMed - indexed for MEDLINE]
17.

Synthesis and in vitro evaluation of novel 2-oxo-1,2-dihydroquinoline CB2 receptor inverse agonists.

Raitio KH, Savinainen JR, Nevalainen T, Järvinen T, Vepsäläinen J.

Chem Biol Drug Des. 2006 Dec;68(6):334-40.

PMID:
17177896
[PubMed - indexed for MEDLINE]
18.

Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide.

Parkkari T, Savinainen JR, Raitio KH, Saario SM, Matilainen L, Sirviö T, Laitinen JT, Nevalainen T, Niemi R, Järvinen T.

Bioorg Med Chem. 2006 Aug 1;14(15):5252-8. Epub 2006 Apr 27.

PMID:
16644227
[PubMed - indexed for MEDLINE]
19.

Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists.

Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T.

J Med Chem. 2006 Mar 23;49(6):2022-7.

PMID:
16539390
[PubMed - indexed for MEDLINE]
20.

Alpha-methylated derivatives of 2-arachidonoyl glycerol: synthesis, CB1 receptor activity, and enzymatic stability.

Parkkari T, Myllymäki M, Savinainen JR, Saario SM, Castillo-Meléndez JA, Laitinen JT, Nevalainen T, Koskinen AM, Järvinen T.

Bioorg Med Chem Lett. 2006 May 1;16(9):2437-40. Epub 2006 Feb 8.

PMID:
16466915
[PubMed - indexed for MEDLINE]
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