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Results: 1 to 20 of 267

1.

Improving efficiency in clinical trials using auxiliary information: Application of a multi-state cure model.

Conlon AS, Taylor JM, Sargent DJ.

Biometrics. 2015 Jan 13. doi: 10.1111/biom.12281. [Epub ahead of print]

PMID:
25585942
[PubMed - as supplied by publisher]
2.

Adaptive randomized phase II design for biomarker threshold selection and independent evaluation.

Renfro LA, Coughlin CM, Grothey AM, Sargent DJ.

Chin Clin Oncol. 2014 Mar 1;3(1). pii: 3489.

PMID:
25485277
[PubMed]
Free PMC Article
3.

Drug designs fulfilling the requirements of clinical trials aiming at personalizing medicine.

Mandrekar SJ, Sargent DJ.

Chin Clin Oncol. 2014 Jun 1;3(2):14.

PMID:
25414851
[PubMed]
Free PMC Article
4.

Individual patient data analysis of progression-free survival versus overall survival as a first-line end point for metastatic colorectal cancer in modern randomized trials: findings from the analysis and research in cancers of the digestive system database.

Shi Q, de Gramont A, Grothey A, Zalcberg J, Chibaudel B, Schmoll HJ, Seymour MT, Adams R, Saltz L, Goldberg RM, Punt CJ, Douillard JY, Hoff PM, Hecht JR, Hurwitz H, Díaz-Rubio E, Porschen R, Tebbutt NC, Fuchs C, Souglakos J, Falcone A, Tournigand C, Kabbinavar FF, Heinemann V, Van Cutsem E, Bokemeyer C, Buyse M, Sargent DJ.

J Clin Oncol. 2015 Jan 1;33(1):22-8. doi: 10.1200/JCO.2014.56.5887. Epub 2014 Nov 10.

PMID:
25385741
[PubMed - in process]
5.

DPYD variants as predictors of 5-fluorouracil toxicity in adjuvant colon cancer treatment (NCCTG N0147).

Lee AM, Shi Q, Pavey E, Alberts SR, Sargent DJ, Sinicrope FA, Berenberg JL, Goldberg RM, Diasio RB.

J Natl Cancer Inst. 2014 Nov 7;106(12). pii: dju298. doi: 10.1093/jnci/dju298. Print 2014 Dec.

PMID:
25381393
[PubMed - indexed for MEDLINE]
6.

ACCENT-based web calculators to predict recurrence and overall survival in stage III colon cancer.

Renfro LA, Grothey A, Xue Y, Saltz LB, André T, Twelves C, Labianca R, Allegra CJ, Alberts SR, Loprinzi CL, Yothers G, Sargent DJ; Adjuvant Colon Cancer Endpoints (ACCENT) Group.

J Natl Cancer Inst. 2014 Oct 29;106(12). pii: dju333. doi: 10.1093/jnci/dju333. Print 2014 Dec.

PMID:
25359867
[PubMed - indexed for MEDLINE]
7.

Resampling the N9741 Trial to Compare Tumor Dynamic Versus Conventional End Points in Randomized Phase II Trials.

Sharma MR, Gray E, Goldberg RM, Sargent DJ, Karrison TG.

J Clin Oncol. 2015 Jan 1;33(1):36-41. doi: 10.1200/JCO.2014.57.2826. Epub 2014 Oct 27.

PMID:
25349295
[PubMed - in process]
8.

Molecular Markers Identify Subtypes of Stage III Colon Cancer Associated With Patient Outcomes.

Sinicrope FA, Shi Q, Smyrk TC, Thibodeau SN, Dienstmann R, Guinney J, Bot BM, Tejpar S, Delorenzi M, Goldberg RM, Mahoney M, Sargent DJ, Alberts SR.

Gastroenterology. 2015 Jan;148(1):88-99. doi: 10.1053/j.gastro.2014.09.041. Epub 2014 Oct 8.

PMID:
25305506
[PubMed - in process]
Free Article
9.

Development and validation of a 20K single nucleotide polymorphism (SNP) whole genome genotyping array for apple (Malus × domestica Borkh).

Bianco L, Cestaro A, Sargent DJ, Banchi E, Derdak S, Di Guardo M, Salvi S, Jansen J, Viola R, Gut I, Laurens F, Chagné D, Velasco R, van de Weg E, Troggio M.

PLoS One. 2014 Oct 10;9(10):e110377. doi: 10.1371/journal.pone.0110377. eCollection 2014.

PMID:
25303088
[PubMed - in process]
Free PMC Article
10.

Decade in review--clinical trials: shifting paradigms in cancer clinical trial design.

Sargent DJ, Korn EL.

Nat Rev Clin Oncol. 2014 Nov;11(11):625-6. doi: 10.1038/nrclinonc.2014.167. Epub 2014 Oct 7. No abstract available.

PMID:
25286977
[PubMed - in process]
11.

Raising the bar for antineoplastic agents: how to choose threshold values for superiority trials in advanced solid tumors.

Sobrero AF, Pastorino A, Sargent DJ, Bruzzi P.

Clin Cancer Res. 2014 Sep 17. pii: clincanres.1505.2014. [Epub ahead of print]

PMID:
25231398
[PubMed - as supplied by publisher]
12.

Looking forward to genetically edited fruit crops.

Nagamangala Kanchiswamy C, Sargent DJ, Velasco R, Maffei ME, Malnoy M.

Trends Biotechnol. 2014 Aug 12. pii: S0167-7799(14)00147-4. doi: 10.1016/j.tibtech.2014.07.003. [Epub ahead of print]

PMID:
25129425
[PubMed - as supplied by publisher]
13.

Design of phase I combination trials: recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee.

Paller CJ, Bradbury PA, Ivy SP, Seymour L, LoRusso PM, Baker L, Rubinstein L, Huang E, Collyar D, Groshen S, Reeves S, Ellis LM, Sargent DJ, Rosner GL, LeBlanc ML, Ratain MJ.

Clin Cancer Res. 2014 Aug 15;20(16):4210-7. doi: 10.1158/1078-0432.CCR-14-0521.

PMID:
25125258
[PubMed - in process]
14.

Center-Within-Trial Versus Trial-Level Evaluation of Surrogate Endpoints.

Renfro LA, Shi Q, Xue Y, Li J, Shang H, Sargent DJ.

Comput Stat Data Anal. 2014 Oct 1;78:1-20.

PMID:
25061255
[PubMed]
15.

Evaluation of a chemoresponse assay as a predictive marker in the treatment of recurrent ovarian cancer: further analysis of a prospective study.

Tian C, Sargent DJ, Krivak TC, Powell MA, Gabrin MJ, Brower SL, Coleman RL.

Br J Cancer. 2014 Aug 26;111(5):843-50. doi: 10.1038/bjc.2014.375. Epub 2014 Jul 8.

PMID:
25003664
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Association of age with survival in patients with metastatic colorectal cancer: analysis from the ARCAD Clinical Trials Program.

Lieu CH, Renfro LA, de Gramont A, Meyers JP, Maughan TS, Seymour MT, Saltz L, Goldberg RM, Sargent DJ, Eckhardt SG, Eng C; Aide et Recherche en Cancérologie Digestive Foundation.

J Clin Oncol. 2014 Sep 20;32(27):2975-84.

PMID:
25002720
[PubMed - in process]
17.

Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147.

Gonsalves WI, Mahoney MR, Sargent DJ, Nelson GD, Alberts SR, Sinicrope FA, Goldberg RM, Limburg PJ, Thibodeau SN, Grothey A, Hubbard JM, Chan E, Nair S, Berenberg JL, McWilliams RR; Alliance for Clinical Trials in Oncology.

J Natl Cancer Inst. 2014 Jun 12;106(7). pii: dju106. doi: 10.1093/jnci/dju106. Print 2014 Jul. Erratum in: J Natl Cancer Inst. 2014 Jul;106(7). doi:10.1093/jnci/dju228.

PMID:
24925349
[PubMed - indexed for MEDLINE]
18.

Molecular testing for lymph node metastases as a determinant of colon cancer recurrence: results from a retrospective multicenter study.

Sargent DJ, Shi Q, Gill S, Louvet C, Everson RB, Kellner U, Clancy TE, Pipas JM, Resnick MB, Meyers MO, Wu TT, Huntsman D, Validire P, Farooq U, Pavey ES, Beaudry G, Haince JF, Fradet Y.

Clin Cancer Res. 2014 Aug 15;20(16):4361-9. doi: 10.1158/1078-0432.CCR-13-2659. Epub 2014 Jun 11.

PMID:
24919572
[PubMed - in process]
19.

Impact of copula directional specification on multi-trial evaluation of surrogate endpoints.

Renfro LA, Shang H, Sargent DJ.

J Biopharm Stat. 2014 Jun 6. [Epub ahead of print]

PMID:
24905465
[PubMed - as supplied by publisher]
20.

Exploring the statistical and clinical impact of two interim analyses on the Phase II design with option for direct assignment.

An MW, Mandrekar SJ, Edelman MJ, Sargent DJ.

Contemp Clin Trials. 2014 Jul;38(2):157-62. doi: 10.1016/j.cct.2014.04.007. Epub 2014 Apr 24.

PMID:
24768938
[PubMed - in process]
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