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Results: 1 to 20 of 22

1.

Inhibition of c-Abl kinase activity renders cancer cells highly sensitive to mitoxantrone.

Alpay K, Farshchian M, Tuomela J, Sandholm J, Aittokallio K, Siljamäki E, Kallio M, Kähäri VM, Hietanen S.

PLoS One. 2014 Aug 22;9(8):e105526. doi: 10.1371/journal.pone.0105526. eCollection 2014.

2.

Toll-like receptor 9 in breast cancer.

Sandholm J, Selander KS.

Front Immunol. 2014 Jul 22;5:330. doi: 10.3389/fimmu.2014.00330. eCollection 2014. Review.

3.

Hypoxia regulates Toll-like receptor-9 expression and invasive function in human brain cancer cells in vitro.

Sandholm J, Tuomela J, Kauppila JH, Harris KW, Graves D, Selander KS.

Oncol Lett. 2014 Jul;8(1):266-274. Epub 2014 Apr 25.

4.

Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer.

Tuomela J, Sandholm J, Kauppila JH, Lehenkari P, Harris KW, Selander KS.

Oncol Lett. 2013 Dec;6(6):1665-1672. Epub 2013 Oct 4.

5.

DNA from dead cancer cells induces TLR9-mediated invasion and inflammation in living cancer cells.

Tuomela J, Sandholm J, Kaakinen M, Patel A, Kauppila JH, Ilvesaro J, Chen D, Harris KW, Graves D, Selander KS.

Breast Cancer Res Treat. 2013 Dec;142(3):477-87. doi: 10.1007/s10549-013-2762-0. Epub 2013 Nov 10.

6.

Low TLR9 expression defines an aggressive subtype of triple-negative breast cancer.

Tuomela J, Sandholm J, Karihtala P, Ilvesaro J, Vuopala KS, Kauppila JH, Kauppila S, Chen D, Pressey C, Härkönen P, Harris KW, Graves D, Auvinen PK, Soini Y, Jukkola-Vuorinen A, Selander KS.

Breast Cancer Res Treat. 2012 Sep;135(2):481-93. doi: 10.1007/s10549-012-2181-7. Epub 2012 Jul 31.

PMID:
22847512
7.

Multiple cellular and molecular mechanisms are involved in human Aβ clearance by transplanted adult astrocytes.

Pihlaja R, Koistinaho J, Kauppinen R, Sandholm J, Tanila H, Koistinaho M.

Glia. 2011 Nov;59(11):1643-57. doi: 10.1002/glia.21212. Epub 2011 Aug 8.

PMID:
21826742
8.

Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes.

Heinonen J, Taipaleenmäki H, Roering P, Takatalo M, Harkness L, Sandholm J, Uusitalo-Järvinen H, Kassem M, Kiviranta I, Laitala-Leinonen T, Säämänen AM.

Osteoarthritis Cartilage. 2011 Aug;19(8):1026-35. doi: 10.1016/j.joca.2011.04.016. Epub 2011 May 17.

9.

Estrogen receptor-α and sex steroid hormones regulate Toll-like receptor-9 expression and invasive function in human breast cancer cells.

Sandholm J, Kauppila JH, Pressey C, Tuomela J, Jukkola-Vuorinen A, Vaarala M, Johnson MR, Harris KW, Selander KS.

Breast Cancer Res Treat. 2012 Apr;132(2):411-9. doi: 10.1007/s10549-011-1590-3. Epub 2011 May 24.

PMID:
21607583
10.

Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate.

Westerlund N, Zdrojewska J, Padzik A, Komulainen E, Björkblom B, Rannikko E, Tararuk T, Garcia-Frigola C, Sandholm J, Nguyen L, Kallunki T, Courtney MJ, Coffey ET.

Nat Neurosci. 2011 Mar;14(3):305-13. doi: 10.1038/nn.2755. Epub 2011 Feb 6.

PMID:
21297631
11.

Fast growth associated with aberrant vasculature and hypoxia in fibroblast growth factor 8b (FGF8b) over-expressing PC-3 prostate tumour xenografts.

Tuomela J, Grönroos TJ, Valta MP, Sandholm J, Schrey A, Seppänen J, Marjamäki P, Forsback S, Kinnunen I, Solin O, Minn H, Härkönen PL.

BMC Cancer. 2010 Oct 30;10:596. doi: 10.1186/1471-2407-10-596.

12.

Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion.

Santio NM, Vahakoski RL, Rainio EM, Sandholm JA, Virtanen SS, Prudhomme M, Anizon F, Moreau P, Koskinen PJ.

Mol Cancer. 2010 Oct 19;9:279. doi: 10.1186/1476-4598-9-279.

13.

Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells.

Virtanen SS, Sandholm J, Yegutkin G, Kalervo Väänänen H, Härkönen PL.

Cell Biol Int. 2010 Aug;34(8):815-26. doi: 10.1042/CBI20090288.

PMID:
20446922
14.

Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor.

Peltola K, Hollmen M, Maula SM, Rainio E, Ristamäki R, Luukkaa M, Sandholm J, Sundvall M, Elenius K, Koskinen PJ, Grenman R, Jalkanen S.

Neoplasia. 2009 Jul;11(7):629-36.

15.

Reconstruction of critical size calvarial bone defects in rabbits with glass-fiber-reinforced composite with bioactive glass granule coating.

Tuusa SM, Peltola MJ, Tirri T, Puska MA, Röyttä M, Aho H, Sandholm J, Lassila LV, Vallittu PK.

J Biomed Mater Res B Appl Biomater. 2008 Feb;84(2):510-9.

PMID:
17618510
16.

Intrinsic properties of so-called dormant probiotic bacteria, determined by flow cytometric viability assays.

Lahtinen SJ, Ouwehand AC, Reinikainen JP, Korpela JM, Sandholm J, Salminen SJ.

Appl Environ Microbiol. 2006 Jul;72(7):5132-4.

17.

Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity.

Aho TL, Sandholm J, Peltola KJ, Ito Y, Koskinen PJ.

BMC Cell Biol. 2006 May 9;7:21.

18.

Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site.

Aho TL, Sandholm J, Peltola KJ, Mankonen HP, Lilly M, Koskinen PJ.

FEBS Lett. 2004 Jul 30;571(1-3):43-9.

PMID:
15280015
19.

Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase.

Rainio EM, Sandholm J, Koskinen PJ.

J Immunol. 2002 Feb 15;168(4):1524-7.

20.
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