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J Viral Hepat. 2010 Oct;17(10):714-9. doi: 10.1111/j.1365-2893.2009.01229.x.

Prevalence and factors associated with significant liver fibrosis assessed by transient elastometry in HIV/hepatitis C virus-coinfected patients.

Collaborators (102)

Fernández R, Rodríguez R, Ocampo A, Grandes-Ibañez J, Pulido F, Rubio R, Mariño A, Valencia E, Moreno V, Cartón-Sanchez JA, Asensi-Alvarez V, Moreno-Torrico A, Sanjoaquín Conde I, García Latas JL, Galindo-Puerto MJ, Ferrer A, Hinojosa C, del Pozo MA, González-Guilabert I, Muñoz-Medina L, Mallolas J, Vergas-García J, Valles P, Pérez-Cecilia E, Campoamor Serrano MT, Colomina Avilés J, Granados Monzón JR, Condés Moreno E, Sola Boneta J, Reparaz Padrós J, Vallecillo Sánchez G, Bahamonde A, Dueñas Gutierrez C, Clotet Sala B, Pedrol Clotet E, Garcia P, Berenguer Berenguer J, Sánchez M, López Bernaldo de Quirós JC, Terron Pernia JA, Ortiz L, Merino Muñoz D, López Aldeguer J, Pascual Catalán A, Arazo Cortés P, Gil Pérez D, Pascua Molina J, Lozano de León F, Sebastián G, Cervantes García M, Blanco Ramos JR, Pérez L, Ojea de Castro R, Paz Vilariño E, Quereda C, San Frutos A, Sanchez Navarro J, Tuya MJ, Alonso Villaverde C, Cuadrado Pastor JM, Jusdado Ruiz-Capilla JJ, Bassa Malondra A, Payeras Cifré A, Homar Borrás F, Domingo Pedrol P, Fontanet A, Gómez Sirvent JL, Alemán R, López Lirola AM, Alonso MM, Rodriguez P, Prieto Martínez A, Antela López A, Losada Arias E, Bachiller Luque P, Castro Iglesias A, López S, Arribas JR, González García J, Pérez Valero I, Sanz Sanz J, Santos I, Sanz Moreno J, Arranz Caso A, Antonio Girón J, López Ruz MA, López M, Pasquau Liaño J, García C, Crespo Casal M, Galera Peñaranda C, Chocarro Martínez A, García I, Viciana P, Rodríguez Baños J, Machado C, Tribis-Arrospe B, García JA, Fuentes MJ, García N, Gomez X, Griffa L.

Author information

  • 1Unit of Infectious Diseases, Hospital Universitario de Valme, Seville, Spain. japineda@telefonica.net

Abstract

Transient elastometry (TE) could provide a more accurate evaluation of the frequency and risk factors of liver fibrosis in hepatitis C virus (HCV) infection than that based on biopsy. The aim of this study was to assess the prevalence of and factors associated with significant liver fibrosis in a large population of HIV/HCV-coinfected patients. HIV/HCV-coinfected patients, who had participated in a cross-sectional, multicenter, retrospective study of liver fibrosis using noninvasive markers and in whom a determination of liver stiffness (LS) by TE was available, were included in this analysis. Factors potentially associated with significant fibrosis (LS ≥ 9 kPa) were analyzed. One thousand three hundred and ten patients fulfilled the inclusion criteria, 526 (40%) of them showed LS ≥ 9 kPa and 316 (24%) cirrhosis (LS ≥ 14 kPa). The factors independently associated with significant fibrosis [adjusted odds ratio (95% confidence interval, P value) were the following: older age [1.04 (1.01-1.07), 0.002], daily alcohol intake > 50 g/day [1.58 (1.10-2.27), 0.013] and the length of HCV infection [1.03 (1.00-1.06), 0.023]]. A CD4 cell count lower than < 200 per mm(3) [1.67 (0.99-2.81), 0.053] and HCV genotype 4 [0.66 (0.42-1.02), 0.066] were marginally associated with LS ≥ 9 kPa. In conclusion, the prevalence of cirrhosis in HIV/HCV-coinfected patients seems to be higher than previously reported in studies based on liver biopsy. Older age, alcohol consumption and lower CD4 cell counts are related with significant fibrosis. The latter association supports an earlier starting of antiretroviral therapy in this setting.

© 2009 Blackwell Publishing Ltd.

PMID:
20002560
[PubMed - indexed for MEDLINE]
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