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Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner.

Calvo JA, Allocca M, Fake KR, Muthupalani S, Corrigan JJ, Bronson RT, Samson LD.

Oncotarget. 2016 Jul 6. doi: 10.18632/oncotarget.10440. [Epub ahead of print]


The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury.

Yu AM, Calvo JA, Muthupalani S, Samson LD.

Oncotarget. 2016 Apr 13. doi: 10.18632/oncotarget.8721. [Epub ahead of print]


Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response.

Beharry AA, Nagel ZD, Samson LD, Kool ET.

PLoS One. 2016 Apr 1;11(4):e0152684. doi: 10.1371/journal.pone.0152684. eCollection 2016.


The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants.

Fu D, Samson LD, Hübscher U, van Loon B.

DNA Repair (Amst). 2015 Nov;35:13-8. doi: 10.1016/j.dnarep.2015.09.008. Epub 2015 Sep 14.


Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide.

McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD.

Cancer Res. 2015 Aug 1;75(15):3127-38. doi: 10.1158/0008-5472.CAN-14-3616. Epub 2015 May 29.


Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney.

Ebrahimkhani MR, Daneshmand A, Mazumder A, Allocca M, Calvo JA, Abolhassani N, Jhun I, Muthupalani S, Ayata C, Samson LD.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4878-86. doi: 10.1073/pnas.1413582111. Epub 2014 Oct 27.


DNA glycosylase activity and cell proliferation are key factors in modulating homologous recombination in vivo.

Kiraly O, Gong G, Roytman MD, Yamada Y, Samson LD, Engelward BP.

Carcinogenesis. 2014 Nov;35(11):2495-502. doi: 10.1093/carcin/bgu177. Epub 2014 Aug 25.


Repair of endogenous DNA base lesions modulate lifespan in mice.

Meira LB, Calvo JA, Shah D, Klapacz J, Moroski-Erkul CA, Bronson RT, Samson LD.

DNA Repair (Amst). 2014 Sep;21:78-86. doi: 10.1016/j.dnarep.2014.05.012. Epub 2014 Jun 30.


Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research.

Nagel ZD, Chaim IA, Samson LD.

DNA Repair (Amst). 2014 Jul;19:199-213. doi: 10.1016/j.dnarep.2014.03.009. Epub 2014 Apr 26.


Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis.

Nagel ZD, Margulies CM, Chaim IA, McRee SK, Mazzucato P, Ahmad A, Abo RP, Butty VL, Forget AL, Samson LD.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1823-32. doi: 10.1073/pnas.1401182111. Epub 2014 Apr 22.


Genomic phenotyping by barcode sequencing broadly distinguishes between alkylating agents, oxidizing agents, and non-genotoxic agents, and reveals a role for aromatic amino acids in cellular recovery after quinone exposure.

Svensson JP, Quirós Pesudo L, McRee SK, Adeleye Y, Carmichael P, Samson LD.

PLoS One. 2013 Sep 9;8(9):e73736. doi: 10.1371/journal.pone.0073736. eCollection 2013.


Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae.

Mazumder A, Pesudo LQ, McRee S, Bathe M, Samson LD.

Nucleic Acids Res. 2013 Nov;41(20):9310-24. doi: 10.1093/nar/gkt715. Epub 2013 Aug 9.


Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis.

Fu D, Jordan JJ, Samson LD.

Genes Dev. 2013 May 15;27(10):1089-100. doi: 10.1101/gad.215533.113. Epub 2013 May 10.


Microfluidic genome-wide profiling of intrinsic electrical properties in Saccharomyces cerevisiae.

Vahey MD, Quiros Pesudo L, Svensson JP, Samson LD, Voldman J.

Lab Chip. 2013 Jul 21;13(14):2754-63. doi: 10.1039/c3lc50162k.


Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1.

Calvo JA, Moroski-Erkul CA, Lake A, Eichinger LW, Shah D, Jhun I, Limsirichai P, Bronson RT, Christiani DC, Meira LB, Samson LD.

PLoS Genet. 2013 Apr;9(4):e1003413. doi: 10.1371/journal.pgen.1003413. Epub 2013 Apr 4.


Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB).

van Loon B, Samson LD.

DNA Repair (Amst). 2013 Mar 1;12(3):177-87. doi: 10.1016/j.dnarep.2012.11.009. Epub 2013 Jan 3.


Single-cell analysis of ribonucleotide reductase transcriptional and translational response to DNA damage.

Mazumder A, Tummler K, Bathe M, Samson LD.

Mol Cell Biol. 2013 Feb;33(3):635-42. doi: 10.1128/MCB.01020-12. Epub 2012 Nov 26.


DNA repair is indispensable for survival after acute inflammation.

Calvo JA, Meira LB, Lee CY, Moroski-Erkul CA, Abolhassani N, Taghizadeh K, Eichinger LW, Muthupalani S, Nordstrand LM, Klungland A, Samson LD.

J Clin Invest. 2012 Jul;122(7):2680-9. doi: 10.1172/JCI63338. Epub 2012 Jun 11.


Identification of novel human damage response proteins targeted through yeast orthology.

Svensson JP, Fry RC, Wang E, Somoza LA, Samson LD.

PLoS One. 2012;7(5):e37368. doi: 10.1371/journal.pone.0037368. Epub 2012 May 16.

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