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Differential regulation of cytotoxicity pathway discriminating between HIV, HCV mono- and co-infection identified by transcriptome profiling of PBMCs.

Wu JQ, Saksena MM, Soriano V, Vispo E, Saksena NK.

Virol J. 2015 Jan 27;12:4. doi: 10.1186/s12985-014-0236-6.


Regulation of gene expression by microRNA in HCV infection and HCV-mediated hepatocellular carcinoma.

Gupta P, Cairns MJ, Saksena NK.

Virol J. 2014 Apr 1;11:64. doi: 10.1186/1743-422X-11-64. Review.


Genome-wide mRNA and miRNA analysis of peripheral blood mononuclear cells (PBMC) reveals different miRNAs regulating HIV/HCV co-infection.

Gupta P, Liu B, Wu JQ, Soriano V, Vispo E, Carroll AP, Goldie BJ, Cairns MJ, Saksena NK.

Virology. 2014 Feb;450-451:336-49. doi: 10.1016/j.virol.2013.12.026. Epub 2014 Jan 14.


HIV Associated Neurocognitive Disorders.

Zhou L, Saksena NK.

Infect Dis Rep. 2013 Jun 6;5(Suppl 1):e8. doi: 10.4081/idr.2013.s1.e8. eCollection 2013 Jun 6. Review.


Special Issue on HIV/AIDS: Infectious Disease Reports.

Saksena NK, Dwyer DE, Zhao RY.

Infect Dis Rep. 2013 Jun 6;5(Suppl 1):e1. doi: 10.4081/idr.2013.s1.e1. eCollection 2013 Jun 6. No abstract available.


Genome-wide analysis of primary peripheral blood mononuclear cells from HIV + patients-pre-and post- HAART show immune activation and inflammation the main drivers of host gene expression.

da Conceicao VN, Dyer WB, Gandhi K, Gupta P, Saksena NK.

Mol Cell Ther. 2014 Apr 3;2:11. doi: 10.1186/2052-8426-2-11. eCollection 2014.


Transcriptome analysis of primary monocytes from HIV-positive patients with differential responses to antiretroviral therapy.

Wu JQ, Sassé TR, Saksena MM, Saksena NK.

Virol J. 2013 Dec 27;10:361. doi: 10.1186/1743-422X-10-361.


Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naïve Subjects with Progressive HIV-1 Subtype C Infection.

Jakobsen MR, Cashin K, Roche M, Sterjovski J, Ellett A, Borm K, Flynn J, Erikstrup C, Gouillou M, Gray LR, Saksena NK, Wang B, Purcell DF, Kallestrup P, Zinyama-Gutsire R, Gomo E, Ullum H, Ostergaard L, Lee B, Ramsland PA, Churchill MJ, Gorry PR.

PLoS One. 2013 Jun 18;8(6):e65950. Print 2013.


Viruses and neurodegeneration.

Zhou L, Miranda-Saksena M, Saksena NK.

Virol J. 2013 May 31;10:172. doi: 10.1186/1743-422X-10-172. Review.


Micro-RNA: new players in HIV-pathogenesis, diagnosis, prognosis and antiviral therapy.

Fowler L, Saksena NK.

AIDS Rev. 2013 Jan-Mar;15(1):3-14. Review.


Gene array data relevant to immunological and virological monitoring of human immunodeficiency virus type 1 infection.

Saksena NK, Conceicao V, Perera SS, Wu J.

Curr Opin HIV AIDS. 2013 Mar;8(2):132-9. doi: 10.1097/COH.0b013e32835ccae1. Review.


A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration.

Zhou L, Pupo GM, Gupta P, Liu B, Tran SL, Rahme R, Wang B, Rua R, Rizos H, Carroll A, Cairns MJ, Saksena NK.

BMC Genomics. 2012 Nov 28;13:677. doi: 10.1186/1471-2164-13-677.


Transcriptome analysis of primary monocytes shows global down-regulation of genetic networks in HIV viremic patients versus long-term non-progressors.

Wu JQ, Sassé TR, Wolkenstein G, Conceicao V, Saksena MM, Soedjono M, Perera SS, Wang B, Dwyer DE, Saksena NK.

Virology. 2013 Jan 20;435(2):308-19. doi: 10.1016/j.virol.2012.10.026. Epub 2012 Nov 13.


Evidence of the circulation of pandemic influenza (H1N1) 2009 with D222D/G/N/S hemagglutinin polymorphisms during the first wave of the 2009 influenza pandemic.

Wang B, Dwyer DE, Soedjono M, Shi H, Matlho K, Ratnamohan M, Blyth C, McPhie K, Cunningham AL, Saksena NK.

J Clin Virol. 2011 Dec;52(4):304-6. doi: 10.1016/j.jcv.2011.08.023. Epub 2011 Sep 16.


Genome-wide analysis of primary CD4+ and CD8+ T cell transcriptomes shows evidence for a network of enriched pathways associated with HIV disease.

Wu JQ, Dwyer DE, Dyer WB, Yang YH, Wang B, Saksena NK.

Retrovirology. 2011 Mar 16;8:18. doi: 10.1186/1742-4690-8-18.


Hierarchical kernel mixture models for the prediction of AIDS disease progression using HIV structural gp120 profiles.

Yoo PD, Shwen Ho Y, Ng J, Charleston M, Saksena NK, Yang P, Zomaya AY.

BMC Genomics. 2010 Dec 2;11 Suppl 4:S22. doi: 10.1186/1471-2164-11-S4-S22.


Both CD31(+) and CD31⁻ naive CD4(+) T cells are persistent HIV type 1-infected reservoirs in individuals receiving antiretroviral therapy.

Wightman F, Solomon A, Khoury G, Green JA, Gray L, Gorry PR, Ho YS, Saksena NK, Hoy J, Crowe SM, Cameron PU, Lewin SR.

J Infect Dis. 2010 Dec 1;202(11):1738-48. doi: 10.1086/656721. Epub 2010 Oct 27.


First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia.

Zhou L, Diefenbach E, Crossett B, Tran SL, Ng T, Rizos H, Rua R, Wang B, Kapur A, Gandhi K, Brew BJ, Saksena NK.

Mol Neurodegener. 2010 Jun 24;5:27. doi: 10.1186/1750-1326-5-27.

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