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Items: 1 to 20 of 228


Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment.

Chaudhari U, Nemade H, Wagh V, Gaspar JA, Ellis JK, Srinivasan SP, Spitkovski D, Nguemo F, Louisse J, Bremer S, Hescheler J, Keun HC, Hengstler JG, Sachinidis A.

Arch Toxicol. 2015 Nov 4. [Epub ahead of print]


Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems.

Rodrigues RM, Heymans A, De Boe V, Sachinidis A, Chaudhari U, Govaere O, Roskams T, Vanhaecke T, Rogiers V, De Kock J.

Toxicol Lett. 2015 Oct 20;240(1):50-59. doi: 10.1016/j.toxlet.2015.10.014. [Epub ahead of print]


Differences in the Early Development of Human and Mouse Embryonic Stem Cells.

Gabdoulline R, Kaisers W, Gaspar A, Meganathan K, Doss MX, Jagtap S, Hescheler J, Sachinidis A, Schwender H.

PLoS One. 2015 Oct 16;10(10):e0140803. doi: 10.1371/journal.pone.0140803. eCollection 2015.


A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.

Rempel E, Hoelting L, Waldmann T, Balmer NV, Schildknecht S, Grinberg M, Das Gaspar JA, Shinde V, Stöber R, Marchan R, van Thriel C, Liebing J, Meisig J, Blüthgen N, Sachinidis A, Rahnenführer J, Hengstler JG, Leist M.

Arch Toxicol. 2015 Sep;89(9):1599-618. doi: 10.1007/s00204-015-1573-y. Epub 2015 Aug 14.


Transcriptomics of Hepatocytes Treated with Toxicants for Investigating Molecular Mechanisms Underlying Hepatotoxicity.

Shinde V, Stöber R, Nemade H, Sotiriadou I, Hescheler J, Hengstler J, Sachinidis A.

Methods Mol Biol. 2015;1250:225-40. doi: 10.1007/978-1-4939-2074-7_16.


Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation.

Shinde V, Klima S, Sureshkumar PS, Meganathan K, Jagtap S, Rempel E, Rahnenführer J, Hengstler JG, Waldmann T, Hescheler J, Leist M, Sachinidis A.

J Vis Exp. 2015 Jun 17;(100):e52333. doi: 10.3791/52333.


Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells.

Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, Björquist P, Widera A, Stöber R, Campos G, Hammad S, Sachinidis A, Chaudhari U, Damm G, Weiss TS, Nüssler A, Synnergren J, Edlund K, Küppers-Munther B, Hay DC, Hengstler JG.

J Hepatol. 2015 Oct;63(4):934-42. doi: 10.1016/j.jhep.2015.05.013. Epub 2015 May 25.


Ascorbic Acid-Induced Cardiac Differentiation of Murine Pluripotent Stem Cells: Transcriptional Profiling and Effect of a Small Molecule Synergist of Wnt/β-Catenin Signaling Pathway.

Ivanyuk D, Budash G, Zheng Y, Gaspar JA, Chaudhari U, Fatima A, Bahmanpour S, Grin VK, Popandopulo AG, Sachinidis A, Hescheler J, Šarić T.

Cell Physiol Biochem. 2015;36(2):810-30. doi: 10.1159/000430140. Epub 2015 May 22.


Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells.

Meganathan K, Jagtap S, Srinivasan SP, Wagh V, Hescheler J, Hengstler J, Leist M, Sachinidis A.

Cell Death Dis. 2015 May 7;6:e1756. doi: 10.1038/cddis.2015.121.


Regulation of liver metabolism by the endosomal GTPase Rab5.

Zeigerer A, Bogorad RL, Sharma K, Gilleron J, Seifert S, Sales S, Berndt N, Bulik S, Marsico G, D'Souza RC, Lakshmanaperumal N, Meganathan K, Natarajan K, Sachinidis A, Dahl A, Holzhütter HG, Shevchenko A, Mann M, Koteliansky V, Zerial M.

Cell Rep. 2015 May 12;11(6):884-92. doi: 10.1016/j.celrep.2015.04.018. Epub 2015 Apr 30.


Stem cells and differentiation--a synoptic review of patents granted since 2009.

Sureshkumar P, Srinivasan SP, Natarajan K, Gaspar JA, Hescheler J, Sachinidis A.

Expert Opin Ther Pat. 2015 Jun;25(6):663-73. doi: 10.1517/13543776.2015.1021334. Epub 2015 Mar 2.


In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells.

Rodrigues RM, Branson S, De Boe V, Sachinidis A, Rogiers V, De Kock J, Vanhaecke T.

Arch Toxicol. 2015 Feb 26. [Epub ahead of print]


Signaling molecules, transcription growth factors and other regulators revealed from in-vivo and in-vitro models for the regulation of cardiac development.

Meganathan K, Sotiriadou I, Natarajan K, Hescheler J, Sachinidis A.

Int J Cardiol. 2015 Mar 15;183:117-28. doi: 10.1016/j.ijcard.2015.01.049. Epub 2015 Jan 27. Review.


Electrophysiological characteristics of embryonic stem cell-derived cardiomyocytes are cell line-dependent.

Hannes T, Wolff M, Doss MX, Pfannkuche K, Haustein M, Müller-Ehmsen J, Sachinidis A, Hescheler J, Khalil M, Halbach M.

Cell Physiol Biochem. 2015;35(1):305-14. doi: 10.1159/000369697. Epub 2015 Jan 10.


Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors.

Rodrigues RM, Sachinidis A, De Boe V, Rogiers V, Vanhaecke T, De Kock J.

Toxicol In Vitro. 2015 Sep;29(6):1231-9. doi: 10.1016/j.tiv.2014.10.012. Epub 2014 Oct 24.


Toxicogenomics directory of chemically exposed human hepatocytes.

Grinberg M, Stöber RM, Edlund K, Rempel E, Godoy P, Reif R, Widera A, Madjar K, Schmidt-Heck W, Marchan R, Sachinidis A, Spitkovsky D, Hescheler J, Carmo H, Arbo MD, van de Water B, Wink S, Vinken M, Rogiers V, Escher S, Hardy B, Mitic D, Myatt G, Waldmann T, Mardinoglu A, Damm G, Seehofer D, Nüssler A, Weiss TS, Oberemm A, Lampen A, Schaap MM, Luijten M, van Steeg H, Thasler WE, Kleinjans JC, Stierum RH, Leist M, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2014 Dec;88(12):2261-87. doi: 10.1007/s00204-014-1400-x. Epub 2014 Nov 16.


A comparative transcriptomic study on the effects of valproic acid on two different hESCs lines in a neural teratogenicity test system.

Colleoni S, Galli C, Gaspar JA, Meganathan K, Jagtap S, Hescheler J, Zagoura D, Bremer S, Sachinidis A, Lazzari G.

Toxicol Lett. 2014 Nov 18;231(1):38-44. doi: 10.1016/j.toxlet.2014.08.023. Epub 2014 Sep 2.


Development of a pluripotent stem cell derived neuronal model to identify chemically induced pathway perturbations in relation to neurotoxicity: effects of CREB pathway inhibition.

Pistollato F, Louisse J, Scelfo B, Mennecozzi M, Accordi B, Basso G, Gaspar JA, Zagoura D, Barilari M, Palosaari T, Sachinidis A, Bremer-Hoffmann S.

Toxicol Appl Pharmacol. 2014 Oct 15;280(2):378-88. doi: 10.1016/j.taap.2014.08.007. Epub 2014 Aug 19.


Lineage-specific regulation of epigenetic modifier genes in human liver and brain.

Weng MK, Natarajan K, Scholz D, Ivanova VN, Sachinidis A, Hengstler JG, Waldmann T, Leist M.

PLoS One. 2014 Jul 23;9(7):e102035. doi: 10.1371/journal.pone.0102035. eCollection 2014.


Fam40b is required for lineage commitment of murine embryonic stem cells.

Wagh V, Doss MX, Sabour D, Niemann R, Meganathan K, Jagtap S, Gaspar JA, Ardestani MA, Papadopoulos S, Gajewski M, Winkler J, Hescheler J, Sachinidis A.

Cell Death Dis. 2014 Jul 10;5:e1320. doi: 10.1038/cddis.2014.273.

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