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Items: 13

1.

DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis.

Hu HY, Lim NH, Ding-Pfennigdorff D, Saas J, Wendt KU, Ritzeler O, Nagase H, Plettenburg O, Schultz C, Nazare M.

Bioconjug Chem. 2015 Mar 18;26(3):383-8. doi: 10.1021/bc500557s. Epub 2015 Feb 12.

PMID:
25629889
2.

Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors.

Halland N, Schmidt F, Weiss T, Saas J, Li Z, Czech J, Dreyer M, Hofmeister A, Mertsch K, Dietz U, Strübing C, Nazare M.

ACS Med Chem Lett. 2014 Oct 23;6(1):73-8. doi: 10.1021/ml5003376. eCollection 2015 Jan 8.

3.

Targeting dynamic pockets of HIV-1 protease by structure-based computational screening for allosteric inhibitors.

Kunze J, Todoroff N, Schneider P, Rodrigues T, Geppert T, Reisen F, Schreuder H, Saas J, Hessler G, Baringhaus KH, Schneider G.

J Chem Inf Model. 2014 Mar 24;54(3):987-91. doi: 10.1021/ci400712h. Epub 2014 Feb 14.

PMID:
24528206
4.

IL-1beta, but not BMP-7 leads to a dramatic change in the gene expression pattern of human adult articular chondrocytes--portraying the gene expression pattern in two donors.

Saas J, Haag J, Rueger D, Chubinskaya S, Sohler F, Zimmer R, Bartnik E, Aigner T.

Cytokine. 2006 Oct;36(1-2):90-9. Epub 2006 Dec 11.

PMID:
17161615
5.

Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis.

Aigner T, Fundel K, Saas J, Gebhard PM, Haag J, Weiss T, Zien A, Obermayr F, Zimmer R, Bartnik E.

Arthritis Rheum. 2006 Nov;54(11):3533-44.

6.

The human chondrosarcoma HCS-2/8 cell line is responsive to BMP-7, but not to IL-1beta.

Saas J, Gebauer M, Jacobi C, Haag J, Takigawa M, Aigner T.

Front Biosci. 2005 May 1;10:2027-35.

PMID:
15970475
7.

Comparison of the chondrosarcoma cell line SW1353 with primary human adult articular chondrocytes with regard to their gene expression profile and reactivity to IL-1beta.

Gebauer M, Saas J, Sohler F, Haag J, Söder S, Pieper M, Bartnik E, Beninga J, Zimmer R, Aigner T.

Osteoarthritis Cartilage. 2005 Aug;13(8):697-708.

8.

Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage.

Gebauer M, Saas J, Haag J, Dietz U, Takigawa M, Bartnik E, Aigner T.

Arthritis Res Ther. 2005;7(2):R274-84. Epub 2005 Jan 11.

9.

Molecular phenotyping of HCS-2/8 cells as an in vitro model of human chondrocytes.

Saas J, Lindauer K, Bau B, Takigawa M, Aigner T.

Osteoarthritis Cartilage. 2004 Nov;12(11):924-34.

10.

Analysis of differential gene expression in healthy and osteoarthritic cartilage and isolated chondrocytes by microarray analysis.

Aigner T, Saas J, Zien A, Zimmer R, Gebhard PM, Knorr T.

Methods Mol Med. 2004;100:109-28.

PMID:
15280592
11.

Procyclic Trypanosoma brucei do not use Krebs cycle activity for energy generation.

van Weelden SW, Fast B, Vogt A, van der Meer P, Saas J, van Hellemond JJ, Tielens AG, Boshart M.

J Biol Chem. 2003 Apr 11;278(15):12854-63. Epub 2003 Jan 31.

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