PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes.
Gass MM, Borkowsky S, Lotz ML, Siwek R, Schröter R, Nedvetsky P, Luschnig S, Rohlmann A, Missler M, Krahn MP.
Gass MM, et al.
Cell Mol Life Sci. 2022 Apr 18;79(5):248. doi: 10.1007/s00018-022-04273-7.
Cell Mol Life Sci. 2022.
PMID: 35437696
Free PMC article.
Here, we demonstrate that both phospholipids are present in the plasma membrane of nephrocytes, but only PI(4,5)P2 accumulates at slit diaphragms. Knockdown of Skittles, a phosphatidylinositol(4)phosphate 5-kinase, which produces PI(4,5)P2, abolished slit diaphragm formati …
Here, we demonstrate that both phospholipids are present in the plasma membrane of nephrocytes, but only PI(4,5)P2 accumulates at slit diaph …