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Items: 13


The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function.

Gu Y, Jones AE, Yang W, Liu S, Dai Q, Liu Y, Swindle CS, Zhou D, Zhang Z, Ryan TM, Townes TM, Klug CA, Chen D, Wang H.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E51-60. doi: 10.1073/pnas.1517041113. Epub 2015 Dec 22.


Erythropoiesis in the absence of adult hemoglobin.

Liu S, McConnell SC, Ryan TM.

Mol Cell Biol. 2013 Jun;33(11):2241-51. doi: 10.1128/MCB.01734-12. Epub 2013 Mar 25.


Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development.

McConnell SC, Huo Y, Liu S, Ryan TM.

Mol Cell Biol. 2011 Feb;31(4):876-83. doi: 10.1128/MCB.00725-10. Epub 2010 Dec 20.


Humanized mouse models of Cooley's anemia: correct fetal-to-adult hemoglobin switching, disease onset, and disease pathology.

Huo Y, McConnell SC, Liu S, Zhang T, Yang R, Ren J, Ryan TM.

Ann N Y Acad Sci. 2010 Aug;1202:45-51. doi: 10.1111/j.1749-6632.2010.05547.x.


Preclinical transfusion-dependent humanized mouse model of beta thalassemia major.

Huo Y, McConnell SC, Ryan TM.

Blood. 2009 May 7;113(19):4763-70. doi: 10.1182/blood-2008-12-197012. Epub 2009 Mar 3.


Humanized Mouse Model of Cooley's Anemia.

Huo Y, McConnell SC, Liu SR, Yang R, Zhang TT, Sun CW, Wu LC, Ryan TM.

J Biol Chem. 2009 Feb 20;284(8):4889-96. doi: 10.1074/jbc.M805681200. Epub 2008 Dec 19.


JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells.

Hock TD, Liby K, Wright MM, McConnell S, Schorpp-Kistner M, Ryan TM, Agarwal A.

J Biol Chem. 2007 Mar 2;282(9):6875-86. Epub 2007 Jan 3.


Correction of sickle cell disease by homologous recombination in embryonic stem cells.

Wu LC, Sun CW, Ryan TM, Pawlik KM, Ren J, Townes TM.

Blood. 2006 Aug 15;108(4):1183-8. Epub 2006 Apr 25.


Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts.

Zhou D, Ren JX, Ryan TM, Higgins NP, Townes TM.

Nucleic Acids Res. 2004 Sep 8;32(16):e128.


A recombinant human hemoglobin with anti-sickling properties greater than fetal hemoglobin.

Levasseur DN, Ryan TM, Reilly MP, McCune SL, Asakura T, Townes TM.

J Biol Chem. 2004 Jun 25;279(26):27518-24. Epub 2004 Apr 14.


Nitric oxide-dependent generation of reactive species in sickle cell disease. Actin tyrosine induces defective cytoskeletal polymerization.

Aslan M, Ryan TM, Townes TM, Coward L, Kirk MC, Barnes S, Alexander CB, Rosenfeld SS, Freeman BA.

J Biol Chem. 2003 Feb 7;278(6):4194-204. Epub 2002 Oct 24.


Distinguishable live erythroid and myeloid cells in beta-globin ECFP x lysozyme EGFP mice.

Heck S, Ermakova O, Iwasaki H, Akashi K, Sun CW, Ryan TM, Townes T, Graf T.

Blood. 2003 Feb 1;101(3):903-6. Epub 2002 Sep 26.

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