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T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration.

Okoye I, Wang L, Pallmer K, Richter K, Ichimura T, Haas R, Crouse J, Choi O, Heathcote D, Lovo E, Mauro C, Abdi R, Oxenius A, Rutschmann S, Ashton-Rickardt PG.

Science. 2015 May 29;348(6238):995-1001. doi: 10.1126/science.aaa7516. Epub 2015 Apr 16.


ENU-induced phenovariance in mice: inferences from 587 mutations.

Arnold CN, Barnes MJ, Berger M, Blasius AL, Brandl K, Croker B, Crozat K, Du X, Eidenschenk C, Georgel P, Hoebe K, Huang H, Jiang Z, Krebs P, La Vine D, Li X, Lyon S, Moresco EM, Murray AR, Popkin DL, Rutschmann S, Siggs OM, Smart NG, Sun L, Tabeta K, Webster V, Tomisato W, Won S, Xia Y, Xiao N, Beutler B.

BMC Res Notes. 2012 Oct 24;5:577. doi: 10.1186/1756-0500-5-577.


Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease.

Siggs OM, Cruite JT, Du X, Rutschmann S, Masliah E, Beutler B, Oldstone MB.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13733-8. doi: 10.1073/pnas.1211499109. Epub 2012 Aug 6.


Dissecting immunity by germline mutagenesis.

Choi O, Rutschmann S.

Immunology. 2012 Oct;137(2):124-30. doi: 10.1111/j.1365-2567.2012.03613.x. Review.


Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice.

Rutschmann S, Crozat K, Li X, Du X, Hanselman JC, Shigeoka AA, Brandl K, Popkin DL, McKay DB, Xia Y, Moresco EM, Beutler B.

G3 (Bethesda). 2012 Apr;2(4):499-504. doi: 10.1534/g3.112.002196. Epub 2012 Apr 1.


A deficiency in nucleoside salvage impairs murine lymphocyte development, homeostasis, and survival.

Choi O, Heathcote DA, Ho KK, Müller PJ, Ghani H, Lam EW, Ashton-Rickardt PG, Rutschmann S.

J Immunol. 2012 Apr 15;188(8):3920-7. doi: 10.4049/jimmunol.1102587. Epub 2012 Mar 9.


Parallel ecological diversification in Antarctic notothenioid fishes as evidence for adaptive radiation.

Rutschmann S, Matschiner M, Damerau M, Muschick M, Lehmann MF, Hanel R, Salzburger W.

Mol Ecol. 2011 Nov;20(22):4707-21. doi: 10.1111/j.1365-294X.2011.05279.x. Epub 2011 Sep 27.


Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner.

Popkin DL, Teijaro JR, Sullivan BM, Urata S, Rutschmann S, de la Torre JC, Kunz S, Beutler B, Oldstone M.

Cell Host Microbe. 2011 Mar 17;9(3):212-22. doi: 10.1016/j.chom.2011.02.006.


Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells.

Blasius AL, Arnold CN, Georgel P, Rutschmann S, Xia Y, Lin P, Ross C, Li X, Smart NG, Beutler B.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19973-8. doi: 10.1073/pnas.1014051107. Epub 2010 Nov 2.


Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response.

Brandl K, Rutschmann S, Li X, Du X, Xiao N, Schnabl B, Brenner DA, Beutler B.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3300-5. doi: 10.1073/pnas.0813036106. Epub 2009 Feb 6.


Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger.

Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15028-33. doi: 10.1073/pnas.0806619105. Epub 2008 Sep 19. Erratum in: Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19561. Rutschmann, Sophie [added].


Dissecting innate immunity by germline mutagenesis.

Rutschmann S, Hoebe K.

Immunology. 2008 Apr;123(4):459-68. doi: 10.1111/j.1365-2567.2007.02786.x. Epub 2008 Jan 18. Review.


Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis.

Crozat K, Hoebe K, Ugolini S, Hong NA, Janssen E, Rutschmann S, Mudd S, Sovath S, Vivier E, Beutler B.

J Exp Med. 2007 Apr 16;204(4):853-63. Epub 2007 Apr 9. Erratum in: J Exp Med. 2008 Mar 17;205(3):737.


Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes.

Munafó DB, Johnson JL, Ellis BA, Rutschmann S, Beutler B, Catz SD.

Biochem J. 2007 Mar 1;402(2):229-39.


Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis.

Jiang Z, Georgel P, Li C, Choe J, Crozat K, Rutschmann S, Du X, Bigby T, Mudd S, Sovath S, Wilson IA, Olson A, Beutler B.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10961-6. Epub 2006 Jul 10.


Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway.

Janssen E, Tabeta K, Barnes MJ, Rutschmann S, McBride S, Bahjat KS, Schoenberger SP, Theofilopoulos AN, Beutler B, Hoebe K.

Immunity. 2006 Jun;24(6):787-99.


PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development.

Rutschmann S, Hoebe K, Zalevsky J, Du X, Mann N, Dahiyat BI, Steed P, Beutler B.

J Immunol. 2006 Jun 15;176(12):7525-32.


Analysis of the MCMV resistome by ENU mutagenesis.

Crozat K, Georgel P, Rutschmann S, Mann N, Du X, Hoebe K, Beutler B.

Mamm Genome. 2006 May;17(5):398-406.


Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.

Beutler B, Jiang Z, Georgel P, Crozat K, Croker B, Rutschmann S, Du X, Hoebe K.

Annu Rev Immunol. 2006;24:353-89. Review.

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