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Results: 1 to 20 of 138

1.

Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays.

Low YS, Sedykh AY, Rusyn I, Tropsha A.

Curr Top Med Chem. 2014;14(11):1356-64.

PMID:
24805064
[PubMed - in process]
2.

Standardizing benchmark dose calculations to improve science-based decisions in human health assessments.

Wignall JA, Shapiro AJ, Wright FA, Woodruff TJ, Chiu WA, Guyton KZ, Rusyn I.

Environ Health Perspect. 2014 May;122(5):499-505. doi: 10.1289/ehp.1307539. Epub 2014 Feb 24.

PMID:
24569956
[PubMed - in process]
Free PMC Article
3.

Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse.

Chiu WA, Campbell JL Jr, Clewell HJ 3rd, Zhou YH, Wright FA, Guyton KZ, Rusyn I.

Environ Health Perspect. 2014 May;122(5):456-63. doi: 10.1289/ehp.1307623. Epub 2014 Feb 10.

PMID:
24518055
[PubMed - in process]
Free PMC Article
4.

Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.

Chappell G, Kutanzi K, Uehara T, Tryndyak V, Hong HH, Hoenerhoff M, Beland FA, Rusyn I, Pogribny IP.

Int J Cancer. 2014 Jun 15;134(12):2778-88. doi: 10.1002/ijc.28610. Epub 2013 Dec 14.

PMID:
24242335
[PubMed - indexed for MEDLINE]
5.

High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells.

Sirenko O, Hesley J, Rusyn I, Cromwell EF.

Assay Drug Dev Technol. 2014 Jan-Feb;12(1):43-54. doi: 10.1089/adt.2013.520. Epub 2013 Nov 14.

PMID:
24229356
[PubMed - in process]
6.

Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix.

Buck LD, Inman SW, Rusyn I, Griffith LG.

Biotechnol Bioeng. 2014 May;111(5):1018-27. doi: 10.1002/bit.25152. Epub 2014 Jan 31.

PMID:
24222008
[PubMed - in process]
7.

Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity.

Sirenko O, Cromwell EF, Crittenden C, Wignall JA, Wright FA, Rusyn I.

Toxicol Appl Pharmacol. 2013 Dec 15;273(3):500-7. doi: 10.1016/j.taap.2013.09.017. Epub 2013 Oct 1.

PMID:
24095675
[PubMed - indexed for MEDLINE]
8.

Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard.

Rusyn I, Chiu WA, Lash LH, Kromhout H, Hansen J, Guyton KZ.

Pharmacol Ther. 2014 Jan;141(1):55-68. doi: 10.1016/j.pharmthera.2013.08.004. Epub 2013 Aug 23.

PMID:
23973663
[PubMed - in process]
9.

A systematic approach for identifying and presenting mechanistic evidence in human health assessments.

Kushman ME, Kraft AD, Guyton KZ, Chiu WA, Makris SL, Rusyn I.

Regul Toxicol Pharmacol. 2013 Nov;67(2):266-77. doi: 10.1016/j.yrtph.2013.08.005. Epub 2013 Aug 16.

PMID:
23959061
[PubMed - indexed for MEDLINE]
10.

Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies?

Rusyn I, Lemon SM.

Cancer Lett. 2014 Apr 10;345(2):210-5. doi: 10.1016/j.canlet.2013.06.028. Epub 2013 Jul 18. Review.

PMID:
23871966
[PubMed - indexed for MEDLINE]
11.

Integrative chemical-biological read-across approach for chemical hazard classification.

Low Y, Sedykh A, Fourches D, Golbraikh A, Whelan M, Rusyn I, Tropsha A.

Chem Res Toxicol. 2013 Aug 19;26(8):1199-208. doi: 10.1021/tx400110f. Epub 2013 Aug 5.

PMID:
23848138
[PubMed - indexed for MEDLINE]
12.

Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches.

Zhang L, Sedykh A, Tripathi A, Zhu H, Afantitis A, Mouchlis VD, Melagraki G, Rusyn I, Tropsha A.

Toxicol Appl Pharmacol. 2013 Oct 1;272(1):67-76. doi: 10.1016/j.taap.2013.04.032. Epub 2013 May 23.

PMID:
23707773
[PubMed - indexed for MEDLINE]
13.

Effects of polymorphisms in alcohol metabolism and oxidative stress genes on survival from head and neck cancer.

Hakenewerth AM, Millikan RC, Rusyn I, Herring AH, Weissler MC, Funkhouser WK, North KE, Barnholtz-Sloan JS, Olshan AF.

Cancer Epidemiol. 2013 Aug;37(4):479-91. doi: 10.1016/j.canep.2013.03.010. Epub 2013 Apr 28.

PMID:
23632049
[PubMed - indexed for MEDLINE]
14.

Reply to: "The autophagic response to alcohol toxicity: the missing layer".

Rusyn I, Bataller R.

J Hepatol. 2013 Aug;59(2):399-400. doi: 10.1016/j.jhep.2013.04.015. Epub 2013 Apr 25. No abstract available.

PMID:
23624250
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

In vitro models for liver toxicity testing.

Soldatow VY, Lecluyse EL, Griffith LG, Rusyn I.

Toxicol Res (Camb). 2013 Jan 1;2(1):23-39. Epub 2012 Nov 23.

PMID:
23495363
[PubMed]
Free PMC Article
16.

Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury.

Pogribny IP, Kutanzi K, Melnyk S, de Conti A, Tryndyak V, Montgomery B, Pogribna M, Muskhelishvili L, Latendresse JR, James SJ, Beland FA, Rusyn I.

FASEB J. 2013 Jun;27(6):2233-43. doi: 10.1096/fj.12-227116. Epub 2013 Feb 25.

PMID:
23439872
[PubMed - indexed for MEDLINE]
Free Article
17.

Alcohol and toxicity.

Rusyn I, Bataller R.

J Hepatol. 2013 Aug;59(2):387-8. doi: 10.1016/j.jhep.2013.01.035. Epub 2013 Feb 4. No abstract available.

PMID:
23391479
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.

Uehara T, Ainslie GR, Kutanzi K, Pogribny IP, Muskhelishvili L, Izawa T, Yamate J, Kosyk O, Shymonyak S, Bradford BU, Boorman GA, Bataller R, Rusyn I.

Toxicol Sci. 2013 Mar;132(1):53-63. doi: 10.1093/toxsci/kfs342. Epub 2013 Jan 3.

PMID:
23288052
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence.

Reif DM, Sypa M, Lock EF, Wright FA, Wilson A, Cathey T, Judson RR, Rusyn I.

Bioinformatics. 2013 Feb 1;29(3):402-3. doi: 10.1093/bioinformatics/bts686. Epub 2012 Nov 29.

PMID:
23202747
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Acetaminophen-induced acute liver injury in HCV transgenic mice.

Uehara T, Kosyk O, Jeannot E, Bradford BU, Tech K, Macdonald JM, Boorman GA, Chatterjee S, Mason RP, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I.

Toxicol Appl Pharmacol. 2013 Jan 15;266(2):224-32. doi: 10.1016/j.taap.2012.11.019. Epub 2012 Nov 29.

PMID:
23200774
[PubMed - indexed for MEDLINE]
Free PMC Article

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