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Results: 1 to 20 of 146

1.

From "weight of evidence" to quantitative data integration using multicriteria decision analysis and Bayesian methods.

Linkov I, Massey O, Keisler J, Rusyn I, Hartung T.

ALTEX. 2015;32(1):3-8. doi: http://dx.doi.org/10.14573/altex.1412231.

PMID:
25592482
[PubMed - in process]
Free Article
2.

High-Content High-Throughput Assays for Characterizing the Viability and Morphology of Human iPSC-Derived Neuronal Cultures.

Sirenko O, Hesley J, Rusyn I, Cromwell EF.

Assay Drug Dev Technol. 2014 Nov-Dec;12(9-10):536-47. doi: 10.1089/adt.2014.592.

PMID:
25506803
[PubMed - in process]
3.

Trichloroethylene Biotransformation and its Role in Mutagenicity, Carcinogenicity and Target Organ Toxicity.

Lash LH, Chiu WA, Guyton KZ, Rusyn I.

Mutat Res Rev Mutat Res. 2014 Oct;762:22-36.

PMID:
25484616
[PubMed]
4.

Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects.

Yoo HS, Bradford BU, Kosyk O, Uehara T, Shymonyak S, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I.

J Toxicol Environ Health A. 2015;78(1):32-49. doi: 10.1080/15287394.2015.958418.

PMID:
25424545
[PubMed - indexed for MEDLINE]
5.

Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.

Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I.

J Toxicol Environ Health A. 2015;78(1):15-31. doi: 10.1080/15287394.2015.958417.

PMID:
25424544
[PubMed - indexed for MEDLINE]
6.

Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice.

Chappell G, Kobets T, O'Brien B, Tretyakova N, Sangaraju D, Kosyk O, Sexton KG, Bodnar W, Pogribny IP, Rusyn I.

Toxicol Sci. 2014 Dec;142(2):375-84. doi: 10.1093/toxsci/kfu191. Epub 2014 Sep 18.

PMID:
25237060
[PubMed - in process]
7.

The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.

Uehara T, Pogribny IP, Rusyn I.

Curr Protoc Pharmacol. 2014 Sep 2;66:14.30.1-14.30.10. doi: 10.1002/0471141755.ph1430s66.

PMID:
25181010
[PubMed - in process]
8.

Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods.

Politi R, Rusyn I, Tropsha A.

Toxicol Appl Pharmacol. 2014 Oct 1;280(1):177-89. doi: 10.1016/j.taap.2014.07.009. Epub 2014 Jul 21.

PMID:
25058446
[PubMed - indexed for MEDLINE]
9.

Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays.

Low YS, Sedykh AY, Rusyn I, Tropsha A.

Curr Top Med Chem. 2014;14(11):1356-64.

PMID:
24805064
[PubMed - in process]
10.

Standardizing benchmark dose calculations to improve science-based decisions in human health assessments.

Wignall JA, Shapiro AJ, Wright FA, Woodruff TJ, Chiu WA, Guyton KZ, Rusyn I.

Environ Health Perspect. 2014 May;122(5):499-505. doi: 10.1289/ehp.1307539. Epub 2014 Feb 24.

PMID:
24569956
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse.

Chiu WA, Campbell JL Jr, Clewell HJ 3rd, Zhou YH, Wright FA, Guyton KZ, Rusyn I.

Environ Health Perspect. 2014 May;122(5):456-63. doi: 10.1289/ehp.1307623. Epub 2014 Feb 10.

PMID:
24518055
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.

Chappell G, Kutanzi K, Uehara T, Tryndyak V, Hong HH, Hoenerhoff M, Beland FA, Rusyn I, Pogribny IP.

Int J Cancer. 2014 Jun 15;134(12):2778-88. doi: 10.1002/ijc.28610. Epub 2013 Dec 14.

PMID:
24242335
[PubMed - indexed for MEDLINE]
13.

High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells.

Sirenko O, Hesley J, Rusyn I, Cromwell EF.

Assay Drug Dev Technol. 2014 Jan-Feb;12(1):43-54. doi: 10.1089/adt.2013.520. Epub 2013 Nov 14.

PMID:
24229356
[PubMed - indexed for MEDLINE]
14.

Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix.

Buck LD, Inman SW, Rusyn I, Griffith LG.

Biotechnol Bioeng. 2014 May;111(5):1018-27. doi: 10.1002/bit.25152. Epub 2014 Jan 31.

PMID:
24222008
[PubMed - indexed for MEDLINE]
15.

Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity.

Sirenko O, Cromwell EF, Crittenden C, Wignall JA, Wright FA, Rusyn I.

Toxicol Appl Pharmacol. 2013 Dec 15;273(3):500-7. doi: 10.1016/j.taap.2013.09.017. Epub 2013 Oct 1.

PMID:
24095675
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard.

Rusyn I, Chiu WA, Lash LH, Kromhout H, Hansen J, Guyton KZ.

Pharmacol Ther. 2014 Jan;141(1):55-68. doi: 10.1016/j.pharmthera.2013.08.004. Epub 2013 Aug 23. Review.

PMID:
23973663
[PubMed - in process]
Free PMC Article
17.

A systematic approach for identifying and presenting mechanistic evidence in human health assessments.

Kushman ME, Kraft AD, Guyton KZ, Chiu WA, Makris SL, Rusyn I.

Regul Toxicol Pharmacol. 2013 Nov;67(2):266-77. doi: 10.1016/j.yrtph.2013.08.005. Epub 2013 Aug 16.

PMID:
23959061
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies?

Rusyn I, Lemon SM.

Cancer Lett. 2014 Apr 10;345(2):210-5. doi: 10.1016/j.canlet.2013.06.028. Epub 2013 Jul 18. Review.

PMID:
23871966
[PubMed - indexed for MEDLINE]
19.

Integrative chemical-biological read-across approach for chemical hazard classification.

Low Y, Sedykh A, Fourches D, Golbraikh A, Whelan M, Rusyn I, Tropsha A.

Chem Res Toxicol. 2013 Aug 19;26(8):1199-208. doi: 10.1021/tx400110f. Epub 2013 Aug 5.

PMID:
23848138
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches.

Zhang L, Sedykh A, Tripathi A, Zhu H, Afantitis A, Mouchlis VD, Melagraki G, Rusyn I, Tropsha A.

Toxicol Appl Pharmacol. 2013 Oct 1;272(1):67-76. doi: 10.1016/j.taap.2013.04.032. Epub 2013 May 23.

PMID:
23707773
[PubMed - indexed for MEDLINE]
Free PMC Article

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