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Results: 1 to 20 of 151

1.

The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.

Yoo HS, Cichocki JA, Kim S, Venkatratnam A, Iwata Y, Kosyk O, Bodnar W, Sweet S, Knap A, Wade T, Campbell J, Clewell HJ, Melnyk SB, Chiu WA, Rusyn I.

Toxicol Sci. 2015 Jul 1. pii: kfv134. [Epub ahead of print]

PMID:
26136231
2.

Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making.

Berggren E, Amcoff P, Benigni R, Blackburn K, Carney E, Cronin M, Deluyker H, Gautier F, Judson RS, Kass GE, Keller D, Knight D, Lilienblum W, Mahony C, Rusyn I, Schultz T, Schwarz M, Sch├╝├╝rmann G, White A, Burton J, Lostia AM, Munn S, Worth A.

Environ Health Perspect. 2015 May 8. [Epub ahead of print] Review.

3.

Differentially expressed microRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice.

Marrone AK, Shpyleva S, Chappell G, Tryndyak V, Uehara T, Tsuchiya M, Beland FA, Rusyn I, Pogribny IP.

Mol Carcinog. 2015 Apr 11. doi: 10.1002/mc.22323. [Epub ahead of print]

PMID:
25865624
4.

IARC monographs: 40 years of evaluating carcinogenic hazards to humans.

Pearce N, Blair A, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli AA, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, 't Mannetje A, McMichael AJ, McLaughlin JR, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer FE, Monson R, Nordby KC, Olshan AF, Parent ME, Perera FP, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Costantini AS, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L, Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart PA, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger D, Wesseling C, Weiderpass E, Zahm SH.

Environ Health Perspect. 2015 Jun;123(6):507-14. doi: 10.1289/ehp.1409149. Epub 2015 Feb 24.

5.

Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study.

Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, Rusyn I, Wright FA.

Environ Health Perspect. 2015 May;123(5):458-66. doi: 10.1289/ehp.1408775. Epub 2015 Jan 13.

6.

From "weight of evidence" to quantitative data integration using multicriteria decision analysis and Bayesian methods.

Linkov I, Massey O, Keisler J, Rusyn I, Hartung T.

ALTEX. 2015;32(1):3-8. doi: http://dx.doi.org/10.14573/altex.1412231.

7.

High-content high-throughput assays for characterizing the viability and morphology of human iPSC-derived neuronal cultures.

Sirenko O, Hesley J, Rusyn I, Cromwell EF.

Assay Drug Dev Technol. 2014 Nov-Dec;12(9-10):536-47. doi: 10.1089/adt.2014.592.

PMID:
25506803
8.

Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity.

Lash LH, Chiu WA, Guyton KZ, Rusyn I.

Mutat Res Rev Mutat Res. 2014 Oct-Dec;762:22-36. Review.

PMID:
25484616
9.

Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects.

Yoo HS, Bradford BU, Kosyk O, Uehara T, Shymonyak S, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I.

J Toxicol Environ Health A. 2015;78(1):32-49. doi: 10.1080/15287394.2015.958418.

PMID:
25424545
10.

Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.

Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I.

J Toxicol Environ Health A. 2015;78(1):15-31. doi: 10.1080/15287394.2015.958417.

PMID:
25424544
11.

Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice.

Chappell G, Kobets T, O'Brien B, Tretyakova N, Sangaraju D, Kosyk O, Sexton KG, Bodnar W, Pogribny IP, Rusyn I.

Toxicol Sci. 2014 Dec;142(2):375-84. doi: 10.1093/toxsci/kfu191. Epub 2014 Sep 18.

PMID:
25237060
12.

The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.

Uehara T, Pogribny IP, Rusyn I.

Curr Protoc Pharmacol. 2014 Sep 2;66:14.30.1-14.30.10. doi: 10.1002/0471141755.ph1430s66.

13.

Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods.

Politi R, Rusyn I, Tropsha A.

Toxicol Appl Pharmacol. 2014 Oct 1;280(1):177-89. doi: 10.1016/j.taap.2014.07.009. Epub 2014 Jul 21.

PMID:
25058446
14.
15.

Standardizing benchmark dose calculations to improve science-based decisions in human health assessments.

Wignall JA, Shapiro AJ, Wright FA, Woodruff TJ, Chiu WA, Guyton KZ, Rusyn I.

Environ Health Perspect. 2014 May;122(5):499-505. doi: 10.1289/ehp.1307539. Epub 2014 Feb 25.

16.

Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse.

Chiu WA, Campbell JL Jr, Clewell HJ 3rd, Zhou YH, Wright FA, Guyton KZ, Rusyn I.

Environ Health Perspect. 2014 May;122(5):456-63. doi: 10.1289/ehp.1307623. Epub 2014 Feb 11.

17.

Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.

Chappell G, Kutanzi K, Uehara T, Tryndyak V, Hong HH, Hoenerhoff M, Beland FA, Rusyn I, Pogribny IP.

Int J Cancer. 2014 Jun 15;134(12):2778-88. doi: 10.1002/ijc.28610. Epub 2013 Dec 14.

18.

High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells.

Sirenko O, Hesley J, Rusyn I, Cromwell EF.

Assay Drug Dev Technol. 2014 Jan-Feb;12(1):43-54. doi: 10.1089/adt.2013.520. Epub 2013 Nov 14.

19.

Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix.

Buck LD, Inman SW, Rusyn I, Griffith LG.

Biotechnol Bioeng. 2014 May;111(5):1018-27. doi: 10.1002/bit.25152. Epub 2014 Jan 31.

20.

Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity.

Sirenko O, Cromwell EF, Crittenden C, Wignall JA, Wright FA, Rusyn I.

Toxicol Appl Pharmacol. 2013 Dec 15;273(3):500-7. doi: 10.1016/j.taap.2013.09.017. Epub 2013 Oct 1.

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