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Xylose-induced dynamic effects on metabolism and gene expression in engineered Saccharomyces cerevisiae in anaerobic glucose-xylose cultures.

Alff-Tuomala S, Salusjärvi L, Barth D, Oja M, Penttilä M, Pitkänen JP, Ruohonen L, Jouhten P.

Appl Microbiol Biotechnol. 2016 Jan;100(2):969-85. doi: 10.1007/s00253-015-7038-7. Epub 2015 Oct 10.


Identification of novel isoprene synthases through genome mining and expression in Escherichia coli.

Ilmén M, Oja M, Huuskonen A, Lee S, Ruohonen L, Jung S.

Metab Eng. 2015 Sep;31:153-62. doi: 10.1016/j.ymben.2015.08.001. Epub 2015 Aug 12.


A novel aldose-aldose oxidoreductase for co-production of D-xylonate and xylitol from D-xylose with Saccharomyces cerevisiae.

Wiebe MG, Nygård Y, Oja M, Andberg M, Ruohonen L, Koivula A, Penttilä M, Toivari M.

Appl Microbiol Biotechnol. 2015 Nov;99(22):9439-47. doi: 10.1007/s00253-015-6878-5. Epub 2015 Aug 12.


L-arabinose/D-galactose 1-dehydrogenase of Rhizobium leguminosarum bv. trifolii characterised and applied for bioconversion of L-arabinose to L-arabonate with Saccharomyces cerevisiae.

Aro-Kärkkäinen N, Toivari M, Maaheimo H, Ylilauri M, Pentikäinen OT, Andberg M, Oja M, Penttilä M, Wiebe MG, Ruohonen L, Koivula A.

Appl Microbiol Biotechnol. 2014 Dec;98(23):9653-65. doi: 10.1007/s00253-014-6039-2. Epub 2014 Sep 19.


Transcriptome of Saccharomyces cerevisiae during production of D-xylonate.

Mojzita D, Oja M, Rintala E, Wiebe M, Penttilä M, Ruohonen L.

BMC Genomics. 2014 Sep 5;15:763. doi: 10.1186/1471-2164-15-763.


L-lactic acid production from D-xylose with Candida sonorensis expressing a heterologous lactate dehydrogenase encoding gene.

Koivuranta KT, Ilmén M, Wiebe MG, Ruohonen L, Suominen P, Penttilä M.

Microb Cell Fact. 2014 Aug 8;13:107. doi: 10.1186/s12934-014-0107-2.


Single cell and in vivo analyses elucidate the effect of xylC lactonase during production of D-xylonate in Saccharomyces cerevisiae.

Nygård Y, Maaheimo H, Mojzita D, Toivari M, Wiebe M, Resnekov O, Gustavo Pesce C, Ruohonen L, Penttilä M.

Metab Eng. 2014 Sep;25:238-47. doi: 10.1016/j.ymben.2014.07.005. Epub 2014 Jul 27.


Effect of oxygenation and temperature on glucose-xylose fermentation in Kluyveromyces marxianus CBS712 strain.

Signori L, Passolunghi S, Ruohonen L, Porro D, Branduardi P.

Microb Cell Fact. 2014 Apr 8;13(1):51. doi: 10.1186/1475-2859-13-51.


The diverse role of Pdr12 in resistance to weak organic acids.

Nygård Y, Mojzita D, Toivari M, Penttilä M, Wiebe MG, Ruohonen L.

Yeast. 2014 Jun;31(6):219-32. doi: 10.1002/yea.3011. Epub 2014 May 6.


Overexpression of NADH-dependent fumarate reductase improves D-xylose fermentation in recombinant Saccharomyces cerevisiae.

Salusjärvi L, Kaunisto S, Holmström S, Vehkomäki ML, Koivuranta K, Pitkänen JP, Ruohonen L.

J Ind Microbiol Biotechnol. 2013 Dec;40(12):1383-92. doi: 10.1007/s10295-013-1344-9. Epub 2013 Oct 10.


Single-cell measurements of enzyme levels as a predictive tool for cellular fates during organic acid production.

Zdraljevic S, Wagner D, Cheng K, Ruohonen L, Jäntti J, Penttilä M, Resnekov O, Pesce CG.

Appl Environ Microbiol. 2013 Dec;79(24):7569-82. doi: 10.1128/AEM.01749-13. Epub 2013 Sep 13.


Production of L-lactic acid by the yeast Candida sonorensis expressing heterologous bacterial and fungal lactate dehydrogenases.

Ilmén M, Koivuranta K, Ruohonen L, Rajgarhia V, Suominen P, Penttilä M.

Microb Cell Fact. 2013 May 25;12:53. doi: 10.1186/1475-2859-12-53.


Low pH D-xylonate production with Pichia kudriavzevii.

Toivari M, Vehkomäki ML, Nygård Y, Penttilä M, Ruohonen L, Wiebe MG.

Bioresour Technol. 2013 Apr;133:555-62. doi: 10.1016/j.biortech.2013.01.157. Epub 2013 Feb 7.


Microbial D-xylonate production.

Toivari MH, Nygård Y, Penttilä M, Ruohonen L, Wiebe MG.

Appl Microbiol Biotechnol. 2012 Oct;96(1):1-8. doi: 10.1007/s00253-012-4288-5. Epub 2012 Aug 9. Review.


Metabolic engineering of Saccharomyces cerevisiae for bioconversion of D-xylose to D-xylonate.

Toivari M, Nygård Y, Kumpula EP, Vehkomäki ML, Benčina M, Valkonen M, Maaheimo H, Andberg M, Koivula A, Ruohonen L, Penttilä M, Wiebe MG.

Metab Eng. 2012 Jul;14(4):427-36. doi: 10.1016/j.ymben.2012.03.002. Epub 2012 Mar 13.


Lipid production in batch and fed-batch cultures of Rhodosporidium toruloides from 5 and 6 carbon carbohydrates.

Wiebe MG, Koivuranta K, Penttilä M, Ruohonen L.

BMC Biotechnol. 2012 May 30;12:26. doi: 10.1186/1472-6750-12-26.


Identification and characterization of a novel diterpene gene cluster in Aspergillus nidulans.

Bromann K, Toivari M, Viljanen K, Vuoristo A, Ruohonen L, Nakari-Setälä T.

PLoS One. 2012;7(4):e35450. doi: 10.1371/journal.pone.0035450. Epub 2012 Apr 10.


Sorbitol dehydrogenase of Aspergillus niger, SdhA, is part of the oxido-reductive D-galactose pathway and essential for D-sorbitol catabolism.

Koivistoinen OM, Richard P, Penttilä M, Ruohonen L, Mojzita D.

FEBS Lett. 2012 Feb 17;586(4):378-83. doi: 10.1016/j.febslet.2012.01.004. Epub 2012 Jan 10.


Identification of the galactitol dehydrogenase, LadB, that is part of the oxido-reductive D-galactose catabolic pathway in Aspergillus niger.

Mojzita D, Koivistoinen OM, Maaheimo H, Penttilä M, Ruohonen L, Richard P.

Fungal Genet Biol. 2012 Feb;49(2):152-9. doi: 10.1016/j.fgb.2011.11.005. Epub 2011 Nov 30.


Identification of regulatory elements in the AGT1 promoter of ale and lager strains of brewer's yeast.

Vidgren V, Kankainen M, Londesborough J, Ruohonen L.

Yeast. 2011 Aug;28(8):579-94. doi: 10.1002/yea.1888. Epub 2011 Jul 13.

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