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Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.

Jetten MJ, Ruiz-Aracama A, Coonen ML, Claessen SM, van Herwijnen MH, Lommen A, van Delft JH, Peijnenburg AA, Kleinjans JC.

Arch Toxicol. 2016 May;90(5):1103-15. doi: 10.1007/s00204-015-1545-2. Epub 2015 Jun 24.


Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro.

Van den Hof WF, Ruiz-Aracama A, Van Summeren A, Jennen DG, Gaj S, Coonen ML, Brauers K, Wodzig WK, van Delft JH, Kleinjans JC.

Toxicol In Vitro. 2015 Apr;29(3):489-501. doi: 10.1016/j.tiv.2014.12.016. Epub 2015 Jan 3.


Identification of cisplatin-regulated metabolic pathways in pluripotent stem cells.

von Stechow L, Ruiz-Aracama A, van de Water B, Peijnenburg A, Danen E, Lommen A.

PLoS One. 2013 Oct 16;8(10):e76476. doi: 10.1371/journal.pone.0076476. eCollection 2013.


Use of NMR metabolomic plasma profiling methodologies to identify illicit growth-promoting administrations.

Graham SF, Ruiz-Aracama A, Lommen A, Cannizzo FT, Biolatti B, Elliott CT, Mooney MH.

Anal Bioanal Chem. 2012 Apr;403(2):573-82. doi: 10.1007/s00216-012-5815-z. Epub 2012 Feb 28.


'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans.

Jetten MJ, Gaj S, Ruiz-Aracama A, de Kok TM, van Delft JH, Lommen A, van Someren EP, Jennen DG, Claessen SM, Peijnenburg AA, Stierum RH, Kleinjans JC.

Toxicol Appl Pharmacol. 2012 Mar 15;259(3):320-8. doi: 10.1016/j.taap.2012.01.009. Epub 2012 Jan 20.


Application of an untargeted metabolomics approach for the identification of compounds that may be responsible for observed differential effects in chickens fed an organic and a conventional diet.

Ruiz-Aracama A, Lommen A, Huber M, van de Vijver L, Hoogenboom R.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012;29(3):323-32. doi: 10.1080/19440049.2011.641163. Epub 2012 Jan 6.


Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells.

Jennen D, Ruiz-Aracama A, Magkoufopoulou C, Peijnenburg A, Lommen A, van Delft J, Kleinjans J.

BMC Syst Biol. 2011 Aug 31;5:139. doi: 10.1186/1752-0509-5-139.


An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Ruiz-Aracama A, Peijnenburg A, Kleinjans J, Jennen D, van Delft J, Hellfrisch C, Lommen A.

BMC Genomics. 2011 May 20;12:251. doi: 10.1186/1471-2164-12-251.


Ultra-fast searching assists in evaluating sub-ppm mass accuracy enhancement in U-HPLC/Orbitrap MS data.

Lommen A, Gerssen A, Oosterink JE, Kools HJ, Ruiz-Aracama A, Peters RJ, Mol HG.

Metabolomics. 2011 Mar;7(1):15-24. Epub 2010 Jul 18.

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