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Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes.

Xu T, Brandmaier S, Messias AC, Herder C, Draisma HH, Demirkan A, Yu Z, Ried JS, Haller T, Heier M, Campillos M, Fobo G, Stark R, Holzapfel C, Adam J, Chi S, Rotter M, Panni T, Quante AS, He Y, Prehn C, Roemisch-Margl W, Kastenmüller G, Willemsen G, Pool R, Kasa K, van Dijk KW, Hankemeier T, Meisinger C, Thorand B, Ruepp A, Hrabé de Angelis M, Li Y, Wichmann HE, Stratmann B, Strauch K, Metspalu A, Gieger C, Suhre K, Adamski J, Illig T, Rathmann W, Roden M, Peters A, van Duijn CM, Boomsma DI, Meitinger T, Wang-Sattler R.

Diabetes Care. 2015 Oct;38(10):1858-67. doi: 10.2337/dc15-0658. Epub 2015 Aug 5.


Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders.

Arloth J, Bogdan R, Weber P, Frishman G, Menke A, Wagner KV, Balsevich G, Schmidt MV, Karbalai N, Czamara D, Altmann A, Trümbach D, Wurst W, Mehta D, Uhr M, Klengel T, Erhardt A, Carey CE, Conley ED; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), Ruepp A, Müller-Myhsok B, Hariri AR, Binder EB; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium PGC.

Neuron. 2015 Jun 3;86(5):1189-202. doi: 10.1016/j.neuron.2015.05.034.


Early predictive biomarkers for postpartum depression point to a role for estrogen receptor signaling.

Mehta D, Newport DJ, Frishman G, Kraus L, Rex-Haffner M, Ritchie JC, Lori A, Knight BT, Stagnaro E, Ruepp A, Stowe ZN, Binder EB.

Psychol Med. 2014 Aug;44(11):2309-22. doi: 10.1017/S0033291713003231. Epub 2014 Feb 5.


Negatome 2.0: a database of non-interacting proteins derived by literature mining, manual annotation and protein structure analysis.

Blohm P, Frishman G, Smialowski P, Goebels F, Wachinger B, Ruepp A, Frishman D.

Nucleic Acids Res. 2014 Jan;42(Database issue):D396-400. doi: 10.1093/nar/gkt1079. Epub 2013 Nov 8.


HoPaCI-DB: host-Pseudomonas and Coxiella interaction database.

Bleves S, Dunger I, Walter MC, Frangoulidis D, Kastenmüller G, Voulhoux R, Ruepp A.

Nucleic Acids Res. 2014 Jan;42(Database issue):D671-6. doi: 10.1093/nar/gkt925. Epub 2013 Oct 16.


HSC-explorer: a curated database for hematopoietic stem cells.

Montrone C, Kokkaliaris KD, Loeffler D, Lechner M, Kastenmüller G, Schroeder T, Ruepp A.

PLoS One. 2013 Jul 30;8(7):e70348. doi: 10.1371/journal.pone.0070348. Print 2013.


CIDeR: multifactorial interaction networks in human diseases.

Lechner M, Höhn V, Brauner B, Dunger I, Fobo G, Frishman G, Montrone C, Kastenmüller G, Waegele B, Ruepp A.

Genome Biol. 2012 Jul 18;13(7):R62. doi: 10.1186/gb-2012-13-7-r62.


PhenomiR: microRNAs in human diseases and biological processes.

Ruepp A, Kowarsch A, Theis F.

Methods Mol Biol. 2012;822:249-60. doi: 10.1007/978-1-61779-427-8_17.


MicroRNAs coordinately regulate protein complexes.

Sass S, Dietmann S, Burk UC, Brabletz S, Lutter D, Kowarsch A, Mayer KF, Brabletz T, Ruepp A, Theis FJ, Wang Y.

BMC Syst Biol. 2011 Aug 25;5:136. doi: 10.1186/1752-0509-5-136.


MIPS: curated databases and comprehensive secondary data resources in 2010.

Mewes HW, Ruepp A, Theis F, Rattei T, Walter M, Frishman D, Suhre K, Spannagl M, Mayer KF, Stümpflen V, Antonov A.

Nucleic Acids Res. 2011 Jan;39(Database issue):D220-4. doi: 10.1093/nar/gkq1157. Epub 2010 Nov 24.


Tissue-specific target analysis of disease-associated microRNAs in human signaling pathways.

Kowarsch A, Marr C, Schmidl D, Ruepp A, Theis FJ.

PLoS One. 2010 Jun 30;5(6):e11154. doi: 10.1371/journal.pone.0011154.


PhenomiR: a knowledgebase for microRNA expression in diseases and biological processes.

Ruepp A, Kowarsch A, Schmidl D, Buggenthin F, Brauner B, Dunger I, Fobo G, Frishman G, Montrone C, Theis FJ.

Genome Biol. 2010 Jan 20;11(1):R6. doi: 10.1186/gb-2010-11-1-r6.


The Negatome database: a reference set of non-interacting protein pairs.

Smialowski P, Pagel P, Wong P, Brauner B, Dunger I, Fobo G, Frishman G, Montrone C, Rattei T, Frishman D, Ruepp A.

Nucleic Acids Res. 2010 Jan;38(Database issue):D540-4. doi: 10.1093/nar/gkp1026. Epub 2009 Nov 17.


CORUM: the comprehensive resource of mammalian protein complexes--2009.

Ruepp A, Waegele B, Lechner M, Brauner B, Dunger-Kaltenbach I, Fobo G, Frishman G, Montrone C, Mewes HW.

Nucleic Acids Res. 2010 Jan;38(Database issue):D497-501. doi: 10.1093/nar/gkp914. Epub 2009 Nov 1.


An evolutionary and structural characterization of mammalian protein complex organization.

Wong P, Althammer S, Hildebrand A, Kirschner A, Pagel P, Geissler B, Smialowski P, Blöchl F, Oesterheld M, Schmidt T, Strack N, Theis FJ, Ruepp A, Frishman D.

BMC Genomics. 2008 Dec 23;9:629. doi: 10.1186/1471-2164-9-629.


CRONOS: the cross-reference navigation server.

Waegele B, Dunger-Kaltenbach I, Fobo G, Montrone C, Mewes HW, Ruepp A.

Bioinformatics. 2009 Jan 1;25(1):141-3. doi: 10.1093/bioinformatics/btn590. Epub 2008 Nov 13.


Rapid access to genes of biotechnologically useful enzymes by partial genome sequencing: the thermoalkaliphile Anaerobranca gottschalkii.

Antranikian G, Ruepp A, Gordon PM, Ballschmiter M, Zibat A, Stark M, Sensen CW, Frishman D, Liebl W, Klenk HP.

J Mol Microbiol Biotechnol. 2009;16(1-2):81-90. doi: 10.1159/000142896. Epub 2008 Oct 29.


OREST: the online resource for EST analysis.

Waegele B, Schmidt T, Mewes HW, Ruepp A.

Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W140-4. doi: 10.1093/nar/gkn253. Epub 2008 May 7.


Evolution in the laboratory: the genome of Halobacterium salinarum strain R1 compared to that of strain NRC-1.

Pfeiffer F, Schuster SC, Broicher A, Falb M, Palm P, Rodewald K, Ruepp A, Soppa J, Tittor J, Oesterhelt D.

Genomics. 2008 Apr;91(4):335-46. doi: 10.1016/j.ygeno.2008.01.001. Epub 2008 Mar 3.


Cellulose as an extracellular matrix component present in Enterobacter sakazakii biofilms.

Grimm M, Stephan R, Iversen C, Manzardo GG, Rattei T, Riedel K, Ruepp A, Frishman D, Lehner A.

J Food Prot. 2008 Jan;71(1):13-8.

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