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Items: 1 to 20 of 102

1.

Studying human disease using human neurons.

Ahfeldt T, Litterman NK, Rubin LL.

Brain Res. 2016 Apr 6. pii: S0006-8993(16)30189-5. doi: 10.1016/j.brainres.2016.03.051. [Epub ahead of print] Review.

PMID:
27060768
2.

Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation.

Walker RG, Poggioli T, Katsimpardi L, Buchanan SM, Oh J, Wattrus S, Heidecker B, Fong YW, Rubin LL, Ganz P, Thompson TB, Wagers AJ, Lee RT.

Circ Res. 2016 Apr 1;118(7):1125-42. doi: 10.1161/CIRCRESAHA.116.308391.

PMID:
27034275
3.

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.

Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R.

Stem Cell Reports. 2015 Dec 8;5(6):933-45. doi: 10.1016/j.stemcr.2015.10.011. Epub 2015 Nov 21.

4.

Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy.

Ng SY, Soh BS, Rodriguez-Muela N, Hendrickson DG, Price F, Rinn JL, Rubin LL.

Cell Stem Cell. 2015 Nov 5;17(5):569-84. doi: 10.1016/j.stem.2015.08.003. Epub 2015 Aug 27.

PMID:
26321202
5.

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.

Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng YH.

Nat Med. 2015 Jul;21(7):760-8. doi: 10.1038/nm.3881. Epub 2015 Jun 15.

6.

A comparison of non-integrating reprogramming methods.

Schlaeger TM, Daheron L, Brickler TR, Entwisle S, Chan K, Cianci A, DeVine A, Ettenger A, Fitzgerald K, Godfrey M, Gupta D, McPherson J, Malwadkar P, Gupta M, Bell B, Doi A, Jung N, Li X, Lynes MS, Brookes E, Cherry AB, Demirbas D, Tsankov AM, Zon LI, Rubin LL, Feinberg AP, Meissner A, Cowan CA, Daley GQ.

Nat Biotechnol. 2015 Jan;33(1):58-63. doi: 10.1038/nbt.3070. Epub 2014 Dec 1.

7.

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.

Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ.

Nat Neurosci. 2015 Jan;18(1):17-24. doi: 10.1038/nn.3886. Epub 2014 Nov 24.

8.

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway.

Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, Davis JC, Peterson QP, Rubin LL, Melton DA.

Elife. 2014 Sep 16;3:e02809. doi: 10.7554/eLife.02809.

9.

Assays for the identification and prioritization of drug candidates for spinal muscular atrophy.

Cherry JJ, Kobayashi DT, Lynes MM, Naryshkin NN, Tiziano FD, Zaworski PG, Rubin LL, Jarecki J.

Assay Drug Dev Technol. 2014 Aug;12(6):315-41. doi: 10.1089/adt.2014.587. Review.

10.

Screening for depressive symptoms in older adults in the Family Health Strategy, Porto Alegre, Brazil.

Nogueira EL, Rubin LL, Giacobbo Sde S, Gomes I, Cataldo Neto A.

Rev Saude Publica. 2014 Jun;48(3):368-77. English, Portuguese.

11.

Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy.

Naryshkin NA, Weetall M, Dakka A, Narasimhan J, Zhao X, Feng Z, Ling KK, Karp GM, Qi H, Woll MG, Chen G, Zhang N, Gabbeta V, Vazirani P, Bhattacharyya A, Furia B, Risher N, Sheedy J, Kong R, Ma J, Turpoff A, Lee CS, Zhang X, Moon YC, Trifillis P, Welch EM, Colacino JM, Babiak J, Almstead NG, Peltz SW, Eng LA, Chen KS, Mull JL, Lynes MS, Rubin LL, Fontoura P, Santarelli L, Haehnke D, McCarthy KD, Schmucki R, Ebeling M, Sivaramakrishnan M, Ko CP, Paushkin SV, Ratni H, Gerlach I, Ghosh A, Metzger F.

Science. 2014 Aug 8;345(6197):688-93. doi: 10.1126/science.1250127.

12.

Notch inhibition allows oncogene-independent generation of iPS cells.

Ichida JK, TCW J, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, Meissner A, Eggan K.

Nat Chem Biol. 2014 Aug;10(8):632-9. doi: 10.1038/nchembio.1552. Epub 2014 Jun 22. Erratum in: Nat Chem Biol. 2014 Dec;10(12):1074. T C W, Julia [corrected to TCW, Julia].

13.

Discovery and preclinical development of vismodegib.

Gould SE, Low JA, Marsters JC Jr, Robarge K, Rubin LL, de Sauvage FJ, Sutherlin DP, Wong H, Yauch RL.

Expert Opin Drug Discov. 2014 Aug;9(8):969-84. doi: 10.1517/17460441.2014.920816. Epub 2014 May 23. Review.

PMID:
24857041
14.

Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors.

Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL.

Science. 2014 May 9;344(6184):630-4. doi: 10.1126/science.1251141. Epub 2014 May 5.

15.

Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy.

Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, Artavanis-Tsakonas S.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):E2371-80. doi: 10.1073/pnas.1301738110. Epub 2013 Jun 11.

16.

A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.

Yang YM, Gupta SK, Kim KJ, Powers BE, Cerqueira A, Wainger BJ, Ngo HD, Rosowski KA, Schein PA, Ackeifi CA, Arvanites AC, Davidow LS, Woolf CJ, Rubin LL.

Cell Stem Cell. 2013 Jun 6;12(6):713-26. doi: 10.1016/j.stem.2013.04.003. Epub 2013 Apr 18.

17.

A TALEN genome-editing system for generating human stem cell-based disease models.

Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA.

Cell Stem Cell. 2013 Feb 7;12(2):238-51. doi: 10.1016/j.stem.2012.11.011. Epub 2012 Dec 13.

18.

Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity.

Wang Y, Davidow L, Arvanites AC, Blanchard J, Lam K, Xu K, Oza V, Yoo JW, Ng JM, Curran T, Rubin LL, McMahon AP.

Chem Biol. 2012 Aug 24;19(8):972-82. doi: 10.1016/j.chembiol.2012.06.012.

19.

A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein.

Hayhurst M, Wagner AK, Cerletti M, Wagers AJ, Rubin LL.

Dev Biol. 2012 Aug 15;368(2):323-34. doi: 10.1016/j.ydbio.2012.05.037. Epub 2012 Jun 15.

20.

Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation.

Wang Y, Arvanites AC, Davidow L, Blanchard J, Lam K, Yoo JW, Coy S, Rubin LL, McMahon AP.

ACS Chem Biol. 2012 Jun 15;7(6):1040-8. doi: 10.1021/cb300028a. Epub 2012 May 3.

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