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Items: 1 to 20 of 33

1.

Antifungal activity improved by coproduction of cyclodextrins and anabaenolysins in Cyanobacteria.

Shishido TK, Jokela J, Kolehmainen CT, Fewer DP, Wahlsten M, Wang H, Rouhiainen L, Rizzi E, De Bellis G, Permi P, Sivonen K.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13669-74. doi: 10.1073/pnas.1510432112. Epub 2015 Oct 16.

2.

Pseudoaeruginosins, nonribosomal peptides in Nodularia spumigena.

Liu L, Budnjo A, Jokela J, Haug BE, Fewer DP, Wahlsten M, Rouhiainen L, Permi P, Fossen T, Sivonen K.

ACS Chem Biol. 2015 Mar 20;10(3):725-33. doi: 10.1021/cb5004306. Epub 2014 Dec 5.

PMID:
25419633
3.

Reply to Sasso et al.: Distribution and phylogeny of nonribosomal peptide and polyketide biosynthetic pathways in eukaryotes.

Wang H, Fewer DP, Holm L, Rouhiainen L, Sivonen K.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E3947. doi: 10.1073/pnas.1413343111. Epub 2014 Sep 2. No abstract available.

4.

Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes.

Wang H, Fewer DP, Holm L, Rouhiainen L, Sivonen K.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9259-64. doi: 10.1073/pnas.1401734111. Epub 2014 Jun 9.

5.

Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway.

Vestola J, Shishido TK, Jokela J, Fewer DP, Aitio O, Permi P, Wahlsten M, Wang H, Rouhiainen L, Sivonen K.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1909-17. doi: 10.1073/pnas.1320913111. Epub 2014 Apr 17.

6.

New structural variants of aeruginosin produced by the toxic bloom forming cyanobacterium Nodularia spumigena.

Fewer DP, Jokela J, Paukku E, Österholm J, Wahlsten M, Permi P, Aitio O, Rouhiainen L, Gomez-Saez GV, Sivonen K.

PLoS One. 2013 Sep 6;8(9):e73618. doi: 10.1371/journal.pone.0073618. eCollection 2013.

7.

The genetic basis for O-acetylation of the microcystin toxin in cyanobacteria.

Fewer DP, Wahlsten M, Österholm J, Jokela J, Rouhiainen L, Kaasalainen U, Rikkinen J, Sivonen K.

Chem Biol. 2013 Jul 25;20(7):861-9. doi: 10.1016/j.chembiol.2013.04.020.

8.

Convergent evolution of [D-Leucine(1)] microcystin-LR in taxonomically disparate cyanobacteria.

Shishido TK, Kaasalainen U, Fewer DP, Rouhiainen L, Jokela J, Wahlsten M, Fiore MF, Yunes JS, Rikkinen J, Sivonen K.

BMC Evol Biol. 2013 Apr 19;13:86. doi: 10.1186/1471-2148-13-86.

9.

Genome-derived insights into the biology of the hepatotoxic bloom-forming cyanobacterium Anabaena sp. strain 90.

Wang H, Sivonen K, Rouhiainen L, Fewer DP, Lyra C, Rantala-Ylinen A, Vestola J, Jokela J, Rantasärkkä K, Li Z, Liu B.

BMC Genomics. 2012 Nov 13;13:613. doi: 10.1186/1471-2164-13-613.

10.

Nostophycin biosynthesis is directed by a hybrid polyketide synthase-nonribosomal peptide synthetase in the toxic cyanobacterium Nostoc sp. strain 152.

Fewer DP, Osterholm J, Rouhiainen L, Jokela J, Wahlsten M, Sivonen K.

Appl Environ Microbiol. 2011 Nov;77(22):8034-40. doi: 10.1128/AEM.05993-11. Epub 2011 Sep 23.

11.

Anatoxin-a synthetase gene cluster of the cyanobacterium Anabaena sp. strain 37 and molecular methods to detect potential producers.

Rantala-Ylinen A, Känä S, Wang H, Rouhiainen L, Wahlsten M, Rizzi E, Berg K, Gugger M, Sivonen K.

Appl Environ Microbiol. 2011 Oct;77(20):7271-8. doi: 10.1128/AEM.06022-11. Epub 2011 Aug 26.

12.

Two alternative starter modules for the non-ribosomal biosynthesis of specific anabaenopeptin variants in Anabaena (Cyanobacteria).

Rouhiainen L, Jokela J, Fewer DP, Urmann M, Sivonen K.

Chem Biol. 2010 Mar 26;17(3):265-73. doi: 10.1016/j.chembiol.2010.01.017.

13.

Highly diverse cyanobactins in strains of the genus Anabaena.

Leikoski N, Fewer DP, Jokela J, Wahlsten M, Rouhiainen L, Sivonen K.

Appl Environ Microbiol. 2010 Feb;76(3):701-9. doi: 10.1128/AEM.01061-09. Epub 2009 Dec 11.

14.

The non-ribosomal assembly and frequent occurrence of the protease inhibitors spumigins in the bloom-forming cyanobacterium Nodularia spumigena.

Fewer DP, Jokela J, Rouhiainen L, Wahlsten M, Koskenniemi K, Stal LJ, Sivonen K.

Mol Microbiol. 2009 Sep;73(5):924-37. doi: 10.1111/j.1365-2958.2009.06816.x. Epub 2009 Aug 19.

15.

Evidence for positive selection acting on microcystin synthetase adenylation domains in three cyanobacterial genera.

Tooming-Klunderud A, Fewer DP, Rohrlack T, Jokela J, Rouhiainen L, Sivonen K, Kristensen T, Jakobsen KS.

BMC Evol Biol. 2008 Sep 22;8:256. doi: 10.1186/1471-2148-8-256.

16.

Natural occurrence of microcystin synthetase deletion mutants capable of producing microcystins in strains of the genus Anabaena (Cyanobacteria).

Fewer DP, Tooming-Klunderud A, Jokela J, Wahlsten M, Rouhiainen L, Kristensen T, Rohrlack T, Jakobsen KS, Sivonen K.

Microbiology. 2008 Apr;154(Pt 4):1007-14. doi: 10.1099/mic.0.2007/016097-0.

PMID:
18375794
17.

Recurrent adenylation domain replacement in the microcystin synthetase gene cluster.

Fewer DP, Rouhiainen L, Jokela J, Wahlsten M, Laakso K, Wang H, Sivonen K.

BMC Evol Biol. 2007 Oct 1;7:183.

18.
19.

Genes coding for hepatotoxic heptapeptides (microcystins) in the cyanobacterium Anabaena strain 90.

Rouhiainen L, Vakkilainen T, Siemer BL, Buikema W, Haselkorn R, Sivonen K.

Appl Environ Microbiol. 2004 Feb;70(2):686-92.

20.

Phylogenetic evidence for the early evolution of microcystin synthesis.

Rantala A, Fewer DP, Hisbergues M, Rouhiainen L, Vaitomaa J, Börner T, Sivonen K.

Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):568-73. Epub 2003 Dec 30.

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