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Results: 1 to 20 of 357

1.

Further evaluation of the tropane analogs of haloperidol.

Sampson D, Bricker B, Zhu XY, Peprah K, Lamango NS, Setola V, Roth BL, Ablordeppey SY.

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4294-7. doi: 10.1016/j.bmcl.2014.07.018. Epub 2014 Jul 14.

PMID:
25070422
[PubMed - in process]
2.

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.

Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC.

Nat Commun. 2014 Jul 10;5:4355. doi: 10.1038/ncomms5355.

PMID:
25008467
[PubMed - in process]
3.

Chemogenetic tools to interrogate brain functions.

Sternson SM, Roth BL.

Annu Rev Neurosci. 2014;37:387-407. doi: 10.1146/annurev-neuro-071013-014048. Epub 2014 Jun 16.

PMID:
25002280
[PubMed - in process]
4.

Silencing synapses with DREADDs.

Zhu H, Roth BL.

Neuron. 2014 May 21;82(4):723-5. doi: 10.1016/j.neuron.2014.05.002.

PMID:
24853931
[PubMed - indexed for MEDLINE]
5.

Identification of a new selective dopamine D4 receptor ligand.

Sampson D, Zhu XY, Eyunni SV, Etukala JR, Ofori E, Bricker B, Lamango NS, Setola V, Roth BL, Ablordeppey SY.

Bioorg Med Chem. 2014 Jun 15;22(12):3105-14. doi: 10.1016/j.bmc.2014.04.026. Epub 2014 Apr 20.

PMID:
24800940
[PubMed - in process]
6.

Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor.

Jin C, Decker AM, Huang XP, Gilmour BP, Blough BE, Roth BL, Hu Y, Gill JB, Zhang XP.

ACS Chem Neurosci. 2014 Jul 16;5(7):576-87. doi: 10.1021/cn500082p. Epub 2014 May 14.

PMID:
24793972
[PubMed - in process]
7.

Allosteric sodium in class A GPCR signaling.

Katritch V, Fenalti G, Abola EE, Roth BL, Cherezov V, Stevens RC.

Trends Biochem Sci. 2014 May;39(5):233-44. doi: 10.1016/j.tibs.2014.03.002. Epub 2014 Apr 21.

PMID:
24767681
[PubMed - in process]
8.

Tuning up the right signal: chemical and genetic approaches to study GPCR functions.

Giguere PM, Kroeze WK, Roth BL.

Curr Opin Cell Biol. 2014 Apr;27:51-5. doi: 10.1016/j.ceb.2013.11.006. Epub 2013 Dec 8. Review.

PMID:
24680430
[PubMed - indexed for MEDLINE]
9.

Chemogenetic inactivation of ventral hippocampal glutamatergic neurons disrupts consolidation of contextual fear memory.

Zhu H, Pleil KE, Urban DJ, Moy SS, Kash TL, Roth BL.

Neuropsychopharmacology. 2014 Jul;39(8):1880-92. doi: 10.1038/npp.2014.35. Epub 2014 Feb 14.

PMID:
24525710
[PubMed - in process]
10.

Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects.

Obradović ALj, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM.

Brain Res. 2014 Mar 20;1554:36-48. doi: 10.1016/j.brainres.2014.01.036. Epub 2014 Jan 25.

PMID:
24472579
[PubMed - in process]
11.

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.

Aristotelous T, Ahn S, Shukla AK, Gawron S, Sassano MF, Kahsai AW, Wingler LM, Zhu X, Tripathi-Shukla P, Huang XP, Riley J, Besnard J, Read KD, Roth BL, Gilbert IH, Hopkins AL, Lefkowitz RJ, Navratilova I.

ACS Med Chem Lett. 2013 Oct 10;4(10):1005-1010. Epub 2013 Sep 3.

PMID:
24454993
[PubMed]
Free PMC Article
12.

Molecular control of δ-opioid receptor signalling.

Fenalti G, Giguere PM, Katritch V, Huang XP, Thompson AA, Cherezov V, Roth BL, Stevens RC.

Nature. 2014 Feb 13;506(7487):191-6. doi: 10.1038/nature12944. Epub 2014 Jan 12.

PMID:
24413399
[PubMed - indexed for MEDLINE]
13.

Application of quantitative structure-activity relationship models of 5-HT1A receptor binding to virtual screening identifies novel and potent 5-HT1A ligands.

Luo M, Wang XS, Roth BL, Golbraikh A, Tropsha A.

J Chem Inf Model. 2014 Feb 24;54(2):634-47. doi: 10.1021/ci400460q. Epub 2014 Feb 12.

PMID:
24410373
[PubMed - in process]
14.

HTS navigator: freely accessible cheminformatics software for analyzing high-throughput screening data.

Fourches D, Sassano MF, Roth BL, Tropsha A.

Bioinformatics. 2014 Feb 15;30(4):588-9. doi: 10.1093/bioinformatics/btt718. Epub 2013 Dec 28.

PMID:
24376084
[PubMed - indexed for MEDLINE]
15.

Molecular interactions between general anesthetics and the 5HT2B receptor.

Matsunaga F, Gao L, Huang XP, Saven JG, Roth BL, Liu R.

J Biomol Struct Dyn. 2013 Dec 23. [Epub ahead of print]

PMID:
24365264
[PubMed - as supplied by publisher]
16.

Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype-targeted drugs.

Meltzer HY, Roth BL.

J Clin Invest. 2013 Dec 2;123(12):4986-91. doi: 10.1172/JCI70678. Epub 2013 Dec 2. Review.

PMID:
24292660
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Novel molecular targets of dezocine and their clinical implications.

Liu R, Huang XP, Yeliseev A, Xi J, Roth BL.

Anesthesiology. 2014 Mar;120(3):714-23. doi: 10.1097/ALN.0000000000000076.

PMID:
24263237
[PubMed - indexed for MEDLINE]
Free Article
18.

In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.

Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K.

PLoS Biol. 2013 Nov;11(11):e1001712. doi: 10.1371/journal.pbio.1001712. Epub 2013 Nov 19.

PMID:
24260022
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

DREADDs: novel tools for drug discovery and development.

Lee HM, Giguere PM, Roth BL.

Drug Discov Today. 2014 Apr;19(4):469-73. doi: 10.1016/j.drudis.2013.10.018. Epub 2013 Nov 1.

PMID:
24184433
[PubMed - in process]
20.

4β-Methyl-5-(3-hydroxyphenyl)morphan opioid agonist and partial agonist derived from a 4β-methyl-5-(3-hydroxyphenyl)morphan pure antagonist.

Carroll FI, Gichinga MG, Williams JD, Vardy E, Roth BL, Mascarella SW, Thomas JB, Navarro HA.

J Med Chem. 2013 Nov 14;56(21):8826-33. doi: 10.1021/jm401250s. Epub 2013 Nov 5.

PMID:
24144404
[PubMed - indexed for MEDLINE]

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