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Results: 1 to 20 of 372

1.

Behavioral and Physiological Effects of a Novel Kappa Opioid Receptor Based DREADD in Rats.

Marchant NJ, Whitaker LR, Bossert JM, Harvey BK, Hope BT, Kaganovsky K, Adhikary S, Prisinzano TE, Vardy E, Roth BL, Shaham Y.

Neuropsychopharmacology. 2015 May 28. doi: 10.1038/npp.2015.149. [Epub ahead of print]

PMID:
26019014
2.

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.

Vardy E, Robinson JE, Li C, Olsen RH, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban DJ, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, Mosier PD, Song J, Kash TL, Malanga CJ, Krashes MJ, Roth BL.

Neuron. 2015 May 20;86(4):936-46. doi: 10.1016/j.neuron.2015.03.065. Epub 2015 Apr 30.

PMID:
25937170
3.

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.

Kroeze WK, Sassano MF, Huang XP, Lansu K, McCorvy JD, Giguère PM, Sciaky N, Roth BL.

Nat Struct Mol Biol. 2015 May;22(5):362-9. doi: 10.1038/nsmb.3014. Epub 2015 Apr 20.

PMID:
25895059
4.

Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.

Robinson JE, Vardy E, DiBerto JF, Chefer VI, White KL, Fish EW, Chen M, Gigante E, Krouse MC, Sun H, Thorsell A, Roth BL, Heilig M, Malanga CJ.

Neuropsychopharmacology. 2015 Apr 16. doi: 10.1038/npp.2015.109. [Epub ahead of print]

PMID:
25881115
5.

Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex.

Nocjar C, Alex KD, Sonneborn A, Abbas AI, Roth BL, Pehek EA.

Neuroscience. 2015 Jun 25;297:22-37. doi: 10.1016/j.neuroscience.2015.03.050. Epub 2015 Mar 27.

PMID:
25818050
6.

A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3).

Kaniskan HÜ, Szewczyk MM, Yu Z, Eram MS, Yang X, Schmidt K, Luo X, Dai M, He F, Zang I, Lin Y, Kennedy S, Li F, Dobrovetsky E, Dong A, Smil D, Min SJ, Landon M, Lin-Jones J, Huang XP, Roth BL, Schapira M, Atadja P, Barsyte-Lovejoy D, Arrowsmith CH, Brown PJ, Zhao K, Jin J, Vedadi M.

Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70. doi: 10.1002/anie.201412154. Epub 2015 Feb 27.

PMID:
25728001
7.

Structural basis for bifunctional peptide recognition at human δ-opioid receptor.

Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, Williams GJ, Gati C, Yefanov OM, White TA, Oberthuer D, Metz M, Yoon CH, Barty A, Chapman HN, Basu S, Coe J, Conrad CE, Fromme R, Fromme P, Tourwé D, Schiller PW, Roth BL, Ballet S, Katritch V, Stevens RC, Cherezov V.

Nat Struct Mol Biol. 2015 Mar;22(3):265-8. doi: 10.1038/nsmb.2965. Epub 2015 Feb 16.

PMID:
25686086
8.

Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.

Cheng J, Giguère PM, Onajole OK, Lv W, Gaisin A, Gunosewoyo H, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Vistoli G, Wetsel WC, Roth BL, Kozikowski AP.

J Med Chem. 2015 Feb 26;58(4):1992-2002. doi: 10.1021/jm5019274. Epub 2015 Feb 10.

PMID:
25633969
9.

Structure and function of serotonin G protein-coupled receptors.

McCorvy JD, Roth BL.

Pharmacol Ther. 2015 Jun;150:129-142. doi: 10.1016/j.pharmthera.2015.01.009. Epub 2015 Jan 17. Review.

PMID:
25601315
10.

The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.

Chen X, Choo H, Huang XP, Yang X, Stone O, Roth BL, Jin J.

ACS Chem Neurosci. 2015 Mar 18;6(3):476-84. doi: 10.1021/cn500325v. Epub 2015 Jan 27.

PMID:
25587888
11.

DREADD: a chemogenetic GPCR signaling platform.

Zhu H, Roth BL.

Int J Neuropsychopharmacol. 2014 Oct 31;18(1). pii: pyu007. doi: 10.1093/ijnp/pyu007.

PMID:
25522378
12.

The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanism.

Cero C, Vostrikov VV, Verardi R, Severini C, Gopinath T, Braun PD, Sassano MF, Gurney A, Roth BL, Vulchanova L, Possenti R, Veglia G, Bartolomucci A.

Structure. 2014 Dec 2;22(12):1744-53. doi: 10.1016/j.str.2014.10.001. Epub 2014 Nov 13.

PMID:
25456411
13.

The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo.

White KL, Robinson JE, Zhu H, DiBerto JF, Polepally PR, Zjawiony JK, Nichols DE, Malanga CJ, Roth BL.

J Pharmacol Exp Ther. 2015 Jan;352(1):98-109. doi: 10.1124/jpet.114.216820. Epub 2014 Oct 15.

PMID:
25320048
14.

DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility.

Urban DJ, Roth BL.

Annu Rev Pharmacol Toxicol. 2015;55:399-417. doi: 10.1146/annurev-pharmtox-010814-124803. Epub 2014 Sep 25.

PMID:
25292433
15.

Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor.

Polepally PR, Huben K, Vardy E, Setola V, Mosier PD, Roth BL, Zjawiony JK.

Eur J Med Chem. 2014 Oct 6;85:818-29. doi: 10.1016/j.ejmech.2014.07.077. Epub 2014 Aug 23.

PMID:
25193297
16.

Further evaluation of the tropane analogs of haloperidol.

Sampson D, Bricker B, Zhu XY, Peprah K, Lamango NS, Setola V, Roth BL, Ablordeppey SY.

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4294-7. doi: 10.1016/j.bmcl.2014.07.018. Epub 2014 Jul 14.

PMID:
25070422
17.

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.

Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC.

Nat Commun. 2014 Jul 10;5:4355. doi: 10.1038/ncomms5355.

PMID:
25008467
18.

Chemogenetic tools to interrogate brain functions.

Sternson SM, Roth BL.

Annu Rev Neurosci. 2014;37:387-407. doi: 10.1146/annurev-neuro-071013-014048. Epub 2014 Jun 16. Review.

PMID:
25002280
19.

Silencing synapses with DREADDs.

Zhu H, Roth BL.

Neuron. 2014 May 21;82(4):723-5. doi: 10.1016/j.neuron.2014.05.002.

20.

Identification of a new selective dopamine D4 receptor ligand.

Sampson D, Zhu XY, Eyunni SV, Etukala JR, Ofori E, Bricker B, Lamango NS, Setola V, Roth BL, Ablordeppey SY.

Bioorg Med Chem. 2014 Jun 15;22(12):3105-14. doi: 10.1016/j.bmc.2014.04.026. Epub 2014 Apr 20.

PMID:
24800940
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