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Results: 1 to 20 of 369

1.

Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.

Elliott Robinson J, Vardy E, DiBerto JF, Chefer VI, White KL, Fish EW, Chen M, Gigante E, Krouse MC, Sun H, Thorsell A, Roth BL, Heilig M, Malanga CJ.

Neuropsychopharmacology. 2015 Apr 16. doi: 10.1038/npp.2015.109. [Epub ahead of print]

PMID:
25881115
2.

Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex.

Nocjar C, Alex KD, Sonneborn A, Abbas AI, Roth BL, Pehek EA.

Neuroscience. 2015 Mar 27;297:22-37. doi: 10.1016/j.neuroscience.2015.03.050. [Epub ahead of print]

PMID:
25818050
3.

A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3).

Kaniskan HÜ, Szewczyk MM, Yu Z, Eram MS, Yang X, Schmidt K, Luo X, Dai M, He F, Zang I, Lin Y, Kennedy S, Li F, Dobrovetsky E, Dong A, Smil D, Min SJ, Landon M, Lin-Jones J, Huang XP, Roth BL, Schapira M, Atadja P, Barsyte-Lovejoy D, Arrowsmith CH, Brown PJ, Zhao K, Jin J, Vedadi M.

Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70. doi: 10.1002/anie.201412154. Epub 2015 Feb 27.

PMID:
25728001
4.

Structural basis for bifunctional peptide recognition at human δ-opioid receptor.

Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, Williams GJ, Gati C, Yefanov OM, White TA, Oberthuer D, Metz M, Yoon CH, Barty A, Chapman HN, Basu S, Coe J, Conrad CE, Fromme R, Fromme P, Tourwé D, Schiller PW, Roth BL, Ballet S, Katritch V, Stevens RC, Cherezov V.

Nat Struct Mol Biol. 2015 Mar;22(3):265-8. doi: 10.1038/nsmb.2965. Epub 2015 Feb 16.

PMID:
25686086
5.

Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.

Cheng J, Giguère PM, Onajole OK, Lv W, Gaisin A, Gunosewoyo H, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Vistoli G, Wetsel WC, Roth BL, Kozikowski AP.

J Med Chem. 2015 Feb 26;58(4):1992-2002. doi: 10.1021/jm5019274. Epub 2015 Feb 10.

PMID:
25633969
6.

Structure and function of serotonin G protein-coupled receptors.

McCorvy JD, Roth BL.

Pharmacol Ther. 2015 Jan 17. pii: S0163-7258(15)00029-7. doi: 10.1016/j.pharmthera.2015.01.009. [Epub ahead of print] Review.

PMID:
25601315
7.

The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.

Chen X, Choo H, Huang XP, Yang X, Stone O, Roth BL, Jin J.

ACS Chem Neurosci. 2015 Mar 18;6(3):476-84. doi: 10.1021/cn500325v. Epub 2015 Jan 27.

PMID:
25587888
8.

DREADD: a chemogenetic GPCR signaling platform.

Zhu H, Roth BL.

Int J Neuropsychopharmacol. 2014 Oct 31;18(1). pii: pyu007. doi: 10.1093/ijnp/pyu007.

PMID:
25522378
9.

The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanism.

Cero C, Vostrikov VV, Verardi R, Severini C, Gopinath T, Braun PD, Sassano MF, Gurney A, Roth BL, Vulchanova L, Possenti R, Veglia G, Bartolomucci A.

Structure. 2014 Dec 2;22(12):1744-53. doi: 10.1016/j.str.2014.10.001. Epub 2014 Nov 13.

PMID:
25456411
10.

The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo.

White KL, Robinson JE, Zhu H, DiBerto JF, Polepally PR, Zjawiony JK, Nichols DE, Malanga CJ, Roth BL.

J Pharmacol Exp Ther. 2015 Jan;352(1):98-109. doi: 10.1124/jpet.114.216820. Epub 2014 Oct 15.

PMID:
25320048
11.

DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility.

Urban DJ, Roth BL.

Annu Rev Pharmacol Toxicol. 2015;55:399-417. doi: 10.1146/annurev-pharmtox-010814-124803. Epub 2014 Sep 25.

PMID:
25292433
12.

Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor.

Polepally PR, Huben K, Vardy E, Setola V, Mosier PD, Roth BL, Zjawiony JK.

Eur J Med Chem. 2014 Oct 6;85:818-29. doi: 10.1016/j.ejmech.2014.07.077. Epub 2014 Aug 23.

PMID:
25193297
13.

Further evaluation of the tropane analogs of haloperidol.

Sampson D, Bricker B, Zhu XY, Peprah K, Lamango NS, Setola V, Roth BL, Ablordeppey SY.

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4294-7. doi: 10.1016/j.bmcl.2014.07.018. Epub 2014 Jul 14.

PMID:
25070422
14.

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.

Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC.

Nat Commun. 2014 Jul 10;5:4355. doi: 10.1038/ncomms5355.

PMID:
25008467
15.

Chemogenetic tools to interrogate brain functions.

Sternson SM, Roth BL.

Annu Rev Neurosci. 2014;37:387-407. doi: 10.1146/annurev-neuro-071013-014048. Epub 2014 Jun 16. Review.

PMID:
25002280
16.

Silencing synapses with DREADDs.

Zhu H, Roth BL.

Neuron. 2014 May 21;82(4):723-5. doi: 10.1016/j.neuron.2014.05.002.

PMID:
24853931
17.

Identification of a new selective dopamine D4 receptor ligand.

Sampson D, Zhu XY, Eyunni SV, Etukala JR, Ofori E, Bricker B, Lamango NS, Setola V, Roth BL, Ablordeppey SY.

Bioorg Med Chem. 2014 Jun 15;22(12):3105-14. doi: 10.1016/j.bmc.2014.04.026. Epub 2014 Apr 20.

PMID:
24800940
18.

Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor.

Jin C, Decker AM, Huang XP, Gilmour BP, Blough BE, Roth BL, Hu Y, Gill JB, Zhang XP.

ACS Chem Neurosci. 2014 Jul 16;5(7):576-87. doi: 10.1021/cn500082p. Epub 2014 May 14.

PMID:
24793972
19.

Allosteric sodium in class A GPCR signaling.

Katritch V, Fenalti G, Abola EE, Roth BL, Cherezov V, Stevens RC.

Trends Biochem Sci. 2014 May;39(5):233-44. doi: 10.1016/j.tibs.2014.03.002. Epub 2014 Apr 21.

PMID:
24767681
20.

Tuning up the right signal: chemical and genetic approaches to study GPCR functions.

Giguere PM, Kroeze WK, Roth BL.

Curr Opin Cell Biol. 2014 Apr;27:51-5. doi: 10.1016/j.ceb.2013.11.006. Epub 2013 Dec 8. Review.

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