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Results: 1 to 20 of 366

1.

Structural basis for bifunctional peptide recognition at human δ-opioid receptor.

Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, Williams GJ, Gati C, Yefanov OM, White TA, Oberthuer D, Metz M, Yoon CH, Barty A, Chapman HN, Basu S, Coe J, Conrad CE, Fromme R, Fromme P, Tourwé D, Schiller PW, Roth BL, Ballet S, Katritch V, Stevens RC, Cherezov V.

Nat Struct Mol Biol. 2015 Feb 16. doi: 10.1038/nsmb.2965. [Epub ahead of print]

PMID:
25686086
[PubMed - as supplied by publisher]
2.

Optimization of 2-Phenylcyclopropylmethylamines as Selective Serotonin 2C Receptor Agonists and Their Evaluation as Potential Antipsychotic Agents.

Cheng J, Giguère PM, Onajole OK, Lv W, Gaisin A, Gunosewoyo H, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Vistoli G, Wetsel WC, Roth BL, Kozikowski AP.

J Med Chem. 2015 Feb 10. [Epub ahead of print]

PMID:
25633969
[PubMed - as supplied by publisher]
3.

Structure and function of serotonin G protein-coupled receptors.

McCorvy JD, Roth BL.

Pharmacol Ther. 2015 Jan 17. pii: S0163-7258(15)00029-7. doi: 10.1016/j.pharmthera.2015.01.009. [Epub ahead of print] Review.

PMID:
25601315
[PubMed - as supplied by publisher]
4.

The First Structure-Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs.

Chen X, Choo H, Huang XP, Yang X, Stone O, Roth BL, Jin J.

ACS Chem Neurosci. 2015 Jan 27. [Epub ahead of print]

PMID:
25587888
[PubMed - as supplied by publisher]
5.

DREADD: A Chemogenetic GPCR Signaling Platform.

Zhu H, Roth BL.

Int J Neuropsychopharmacol. 2014 Oct 31;18(1). pii: pyu007. doi: 10.1093/ijnp/pyu007.

PMID:
25522378
[PubMed - in process]
6.

The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanism.

Cero C, Vostrikov VV, Verardi R, Severini C, Gopinath T, Braun PD, Sassano MF, Gurney A, Roth BL, Vulchanova L, Possenti R, Veglia G, Bartolomucci A.

Structure. 2014 Dec 2;22(12):1744-53. doi: 10.1016/j.str.2014.10.001. Epub 2014 Nov 13.

PMID:
25456411
[PubMed - in process]
7.

The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo.

White KL, Robinson JE, Zhu H, DiBerto JF, Polepally PR, Zjawiony JK, Nichols DE, Malanga CJ, Roth BL.

J Pharmacol Exp Ther. 2015 Jan;352(1):98-109. doi: 10.1124/jpet.114.216820. Epub 2014 Oct 15.

PMID:
25320048
[PubMed - indexed for MEDLINE]
8.

DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility.

Urban DJ, Roth BL.

Annu Rev Pharmacol Toxicol. 2015;55:399-417. doi: 10.1146/annurev-pharmtox-010814-124803. Epub 2014 Sep 25.

PMID:
25292433
[PubMed - in process]
9.

Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor.

Polepally PR, Huben K, Vardy E, Setola V, Mosier PD, Roth BL, Zjawiony JK.

Eur J Med Chem. 2014 Oct 6;85:818-29. doi: 10.1016/j.ejmech.2014.07.077. Epub 2014 Aug 23.

PMID:
25193297
[PubMed - in process]
10.

Further evaluation of the tropane analogs of haloperidol.

Sampson D, Bricker B, Zhu XY, Peprah K, Lamango NS, Setola V, Roth BL, Ablordeppey SY.

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4294-7. doi: 10.1016/j.bmcl.2014.07.018. Epub 2014 Jul 14.

PMID:
25070422
[PubMed - in process]
11.

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.

Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC.

Nat Commun. 2014 Jul 10;5:4355. doi: 10.1038/ncomms5355.

PMID:
25008467
[PubMed - in process]
12.

Chemogenetic tools to interrogate brain functions.

Sternson SM, Roth BL.

Annu Rev Neurosci. 2014;37:387-407. doi: 10.1146/annurev-neuro-071013-014048. Epub 2014 Jun 16.

PMID:
25002280
[PubMed - in process]
13.

Silencing synapses with DREADDs.

Zhu H, Roth BL.

Neuron. 2014 May 21;82(4):723-5. doi: 10.1016/j.neuron.2014.05.002.

PMID:
24853931
[PubMed - indexed for MEDLINE]
14.

Identification of a new selective dopamine D4 receptor ligand.

Sampson D, Zhu XY, Eyunni SV, Etukala JR, Ofori E, Bricker B, Lamango NS, Setola V, Roth BL, Ablordeppey SY.

Bioorg Med Chem. 2014 Jun 15;22(12):3105-14. doi: 10.1016/j.bmc.2014.04.026. Epub 2014 Apr 20.

PMID:
24800940
[PubMed - in process]
15.

Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor.

Jin C, Decker AM, Huang XP, Gilmour BP, Blough BE, Roth BL, Hu Y, Gill JB, Zhang XP.

ACS Chem Neurosci. 2014 Jul 16;5(7):576-87. doi: 10.1021/cn500082p. Epub 2014 May 14.

PMID:
24793972
[PubMed - in process]
16.

Allosteric sodium in class A GPCR signaling.

Katritch V, Fenalti G, Abola EE, Roth BL, Cherezov V, Stevens RC.

Trends Biochem Sci. 2014 May;39(5):233-44. doi: 10.1016/j.tibs.2014.03.002. Epub 2014 Apr 21.

PMID:
24767681
[PubMed - indexed for MEDLINE]
17.

Tuning up the right signal: chemical and genetic approaches to study GPCR functions.

Giguere PM, Kroeze WK, Roth BL.

Curr Opin Cell Biol. 2014 Apr;27:51-5. doi: 10.1016/j.ceb.2013.11.006. Epub 2013 Dec 8. Review.

PMID:
24680430
[PubMed - indexed for MEDLINE]
18.

Chemogenetic inactivation of ventral hippocampal glutamatergic neurons disrupts consolidation of contextual fear memory.

Zhu H, Pleil KE, Urban DJ, Moy SS, Kash TL, Roth BL.

Neuropsychopharmacology. 2014 Jul;39(8):1880-92. doi: 10.1038/npp.2014.35. Epub 2014 Feb 14.

PMID:
24525710
[PubMed - indexed for MEDLINE]
19.

Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects.

Obradović ALj, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM.

Brain Res. 2014 Mar 20;1554:36-48. doi: 10.1016/j.brainres.2014.01.036. Epub 2014 Jan 25.

PMID:
24472579
[PubMed - indexed for MEDLINE]
20.

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.

Aristotelous T, Ahn S, Shukla AK, Gawron S, Sassano MF, Kahsai AW, Wingler LM, Zhu X, Tripathi-Shukla P, Huang XP, Riley J, Besnard J, Read KD, Roth BL, Gilbert IH, Hopkins AL, Lefkowitz RJ, Navratilova I.

ACS Med Chem Lett. 2013 Oct 10;4(10):1005-1010. Epub 2013 Sep 3.

PMID:
24454993
[PubMed]
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