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Items: 1 to 20 of 385

1.

New Technologies for Elucidating Opioid Receptor Function.

Bruchas MR, Roth BL.

Trends Pharmacol Sci. 2016 Jan 29. pii: S0165-6147(16)00002-X. doi: 10.1016/j.tips.2016.01.001. [Epub ahead of print] Review.

PMID:
26833118
2.

A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.

Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, Senisterra G, Pattenden SG, Vedadi M, Brown PJ, Bedford MT, Min J, Arrowsmith CH, James LI, Frye SV.

Nat Chem Biol. 2016 Jan 25. doi: 10.1038/nchembio.2007. [Epub ahead of print]

PMID:
26807715
3.

Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.

Cheng J, Giguere PM, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Huang XP, Zhu H, McCorvy JD, Wetsel WC, Roth BL, Kozikowski AP.

J Med Chem. 2016 Jan 28;59(2):578-91. doi: 10.1021/acs.jmedchem.5b01153. Epub 2016 Jan 13.

PMID:
26704965
4.

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.

Huang XP, Karpiak J, Kroeze WK, Zhu H, Chen X, Moy SS, Saddoris KA, Nikolova VD, Farrell MS, Wang S, Mangano TJ, Deshpande DA, Jiang A, Penn RB, Jin J, Koller BH, Kenakin T, Shoichet BK, Roth BL.

Nature. 2015 Nov 26;527(7579):477-83. doi: 10.1038/nature15699. Epub 2015 Nov 9.

PMID:
26550826
5.

Comprehensive characterization of the Published Kinase Inhibitor Set.

Elkins JM, Fedele V, Szklarz M, Abdul Azeez KR, Salah E, Mikolajczyk J, Romanov S, Sepetov N, Huang XP, Roth BL, Al Haj Zen A, Fourches D, Muratov E, Tropsha A, Morris J, Teicher BA, Kunkel M, Polley E, Lackey KE, Atkinson FL, Overington JP, Bamborough P, Müller S, Price DJ, Willson TM, Drewry DH, Knapp S, Zuercher WJ.

Nat Biotechnol. 2016 Jan;34(1):95-103. doi: 10.1038/nbt.3374. Epub 2015 Oct 26.

6.

Chemogenetics-A Transformational and Translational Platform.

English JG, Roth BL.

JAMA Neurol. 2015 Nov 1;72(11):1361-6. doi: 10.1001/jamaneurol.2015.1921.

PMID:
26409113
7.

Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons.

Urban DJ, Zhu H, Marcinkiewcz CA, Michaelides M, Oshibuchi H, Rhea D, Aryal DK, Farrell MS, Lowery-Gionta E, Olsen RH, Wetsel WC, Kash TL, Hurd YL, Tecott LH, Roth BL.

Neuropsychopharmacology. 2015 Sep 18. doi: 10.1038/npp.2015.293. [Epub ahead of print]

PMID:
26383016
8.

NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor.

O'Connor C, White KL, Doncescu N, Didenko T, Roth BL, Czaplicki G, Stevens RC, Wüthrich K, Milon A.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11852-7. doi: 10.1073/pnas.1510117112. Epub 2015 Sep 8.

PMID:
26372966
9.

Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability.

Zhang Z, Kil KE, Poutiainen P, Choi JK, Kang HJ, Huang XP, Roth BL, Brownell AL.

Bioorg Med Chem Lett. 2015 Sep 15;25(18):3956-60. doi: 10.1016/j.bmcl.2015.07.031. Epub 2015 Jul 17.

PMID:
26231155
10.

Design and Synthesis of (2-(5-Chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)methanamine as a Selective Serotonin 2C Agonist.

Cheng J, Giguere PM, Lv W, Roth BL, Kozikowski AP.

Tetrahedron Lett. 2015 Jun 3;56(23):3420-3422.

PMID:
26120215
11.

Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily.

Roth BL, Kroeze WK.

J Biol Chem. 2015 Aug 7;290(32):19471-7. doi: 10.1074/jbc.R115.654764. Epub 2015 Jun 22. Review.

PMID:
26100629
12.

Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides.

Vardy E, Sassano MF, Rennekamp AJ, Kroeze WK, Mosier PD, Westkaemper RB, Stevens CW, Katritch V, Stevens RC, Peterson RT, Roth BL.

Chem Biol. 2015 Jun 18;22(6):764-75. doi: 10.1016/j.chembiol.2015.05.012.

PMID:
26091169
13.

Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice.

Salaga M, Polepally PR, Zielinska M, Marynowski M, Fabisiak A, Murawska N, Sobczak K, Sacharczuk M, Do Rego JC, Roth BL, Zjawiony JK, Fichna J.

Br J Pharmacol. 2015 Sep;172(17):4331-41. doi: 10.1111/bph.13212. Epub 2015 Jul 14.

PMID:
26040667
14.

Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats.

Marchant NJ, Whitaker LR, Bossert JM, Harvey BK, Hope BT, Kaganovsky K, Adhikary S, Prisinzano TE, Vardy E, Roth BL, Shaham Y.

Neuropsychopharmacology. 2016 Jan;41(2):402-9. doi: 10.1038/npp.2015.149. Epub 2015 May 28.

PMID:
26019014
15.

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.

Vardy E, Robinson JE, Li C, Olsen RH, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban DJ, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, Mosier PD, Song J, Kash TL, Malanga CJ, Krashes MJ, Roth BL.

Neuron. 2015 May 20;86(4):936-46. doi: 10.1016/j.neuron.2015.03.065. Epub 2015 Apr 30.

PMID:
25937170
16.

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.

Kroeze WK, Sassano MF, Huang XP, Lansu K, McCorvy JD, Giguère PM, Sciaky N, Roth BL.

Nat Struct Mol Biol. 2015 May;22(5):362-9. doi: 10.1038/nsmb.3014. Epub 2015 Apr 20.

17.

Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.

Robinson JE, Vardy E, DiBerto JF, Chefer VI, White KL, Fish EW, Chen M, Gigante E, Krouse MC, Sun H, Thorsell A, Roth BL, Heilig M, Malanga CJ.

Neuropsychopharmacology. 2015 Oct;40(11):2614-22. doi: 10.1038/npp.2015.109. Epub 2015 Apr 16.

PMID:
25881115
18.

Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex.

Nocjar C, Alex KD, Sonneborn A, Abbas AI, Roth BL, Pehek EA.

Neuroscience. 2015 Jun 25;297:22-37. doi: 10.1016/j.neuroscience.2015.03.050. Epub 2015 Mar 27.

PMID:
25818050
19.

A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).

Kaniskan HÜ, Szewczyk MM, Yu Z, Eram MS, Yang X, Schmidt K, Luo X, Dai M, He F, Zang I, Lin Y, Kennedy S, Li F, Dobrovetsky E, Dong A, Smil D, Min SJ, Landon M, Lin-Jones J, Huang XP, Roth BL, Schapira M, Atadja P, Barsyte-Lovejoy D, Arrowsmith CH, Brown PJ, Zhao K, Jin J, Vedadi M.

Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70. doi: 10.1002/anie.201412154. Epub 2015 Feb 27.

PMID:
25728001
20.

Structural basis for bifunctional peptide recognition at human δ-opioid receptor.

Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, Williams GJ, Gati C, Yefanov OM, White TA, Oberthuer D, Metz M, Yoon CH, Barty A, Chapman HN, Basu S, Coe J, Conrad CE, Fromme R, Fromme P, Tourwé D, Schiller PW, Roth BL, Ballet S, Katritch V, Stevens RC, Cherezov V.

Nat Struct Mol Biol. 2015 Mar;22(3):265-8. doi: 10.1038/nsmb.2965. Epub 2015 Feb 16.

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