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Results: 1 to 20 of 60


Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor.

Freeman SA, Jaumouillé V, Choi K, Hsu BE, Wong HS, Abraham L, Graves ML, Coombs D, Roskelley CD, Das R, Grinstein S, Gold MR.

Nat Commun. 2015 Feb 3;6:6168. doi: 10.1038/ncomms7168.


The invasion inhibitor sarasinoside A1 reverses mesenchymal tumor transformation in an E-cadherin-independent manner.

Austin P, Freeman SA, Gray CA, Gold MR, Vogl AW, Andersen RJ, Roberge M, Roskelley CD.

Mol Cancer Res. 2013 May;11(5):530-40. doi: 10.1158/1541-7786.MCR-12-0385. Epub 2013 Feb 11.


Microenvironmental regulation of BRCA1 gene expression by c-Jun and Fra2 in premalignant human ovarian surface epithelial cells.

Zhou L, Graves M, MacDonald G, Cipollone J, Mueller CR, Roskelley CD.

Mol Cancer Res. 2013 Mar;11(3):272-81. doi: 10.1158/1541-7786.MCR-12-0395. Epub 2013 Jan 21.


Synthesis and biological studies of neopetrosiamides as inhibitors of cancer cell invasion.

Towle KM, Chaytor JL, Liu H, Austin P, Roberge M, Roskelley CD, Vederas JC.

Org Biomol Chem. 2013 Mar 7;11(9):1476-81. doi: 10.1039/c3ob27238a.


The small molecule genkwanine M induces single mode, mesenchymal tumor cell motility.

Zimmerman C, Austin P, Khong A, McLeod S, Bean B, Forestieri R, Andersen RJ, Jan E, Roberge M, Roskelley CD.

Exp Cell Res. 2013 Apr 1;319(6):908-17. doi: 10.1016/j.yexcr.2013.01.005. Epub 2013 Jan 17.


The anti-adhesive mucin podocalyxin may help initiate the transperitoneal metastasis of high grade serous ovarian carcinoma.

Cipollone JA, Graves ML, Köbel M, Kalloger SE, Poon T, Gilks CB, McNagny KM, Roskelley CD.

Clin Exp Metastasis. 2012 Mar;29(3):239-52. doi: 10.1007/s10585-011-9446-0. Epub 2012 Jan 20.


Organellar (Na+, K+)/H+ exchanger NHE7 regulates cell adhesion, invasion and anchorage-independent growth of breast cancer MDA-MB-231 cells.

Onishi I, Lin PJ, Numata Y, Austin P, Cipollone J, Roberge M, Roskelley CD, Numata M.

Oncol Rep. 2012 Feb;27(2):311-7. doi: 10.3892/or.2011.1542. Epub 2011 Nov 9.


Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation.

Freeman SA, Lei V, Dang-Lawson M, Mizuno K, Roskelley CD, Gold MR.

J Immunol. 2011 Dec 1;187(11):5887-900. doi: 10.4049/jimmunol.1102233. Epub 2011 Nov 7.


Opposing roles for CD34 in B16 melanoma tumor growth alter early stage vasculature and late stage immune cell infiltration.

Maltby S, Freeman S, Gold MJ, Baker JH, Minchinton AI, Gold MR, Roskelley CD, McNagny KM.

PLoS One. 2011 Apr 11;6(4):e18160. doi: 10.1371/journal.pone.0018160.


ETV6-NTRK3-mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway.

Tognon CE, Somasiri AM, Evdokimova VE, Trigo G, Uy EE, Melnyk N, Carboni JM, Gottardis MM, Roskelley CD, Pollak M, Sorensen PH.

Cancer Res. 2011 Feb 1;71(3):1060-70. doi: 10.1158/0008-5472.CAN-10-3096. Epub 2010 Dec 9.


Release of membrane-bound vesicles and inhibition of tumor cell adhesion by the peptide Neopetrosiamide A.

Austin P, Heller M, Williams DE, McIntosh LP, Vogl AW, Foster LJ, Andersen RJ, Roberge M, Roskelley CD.

PLoS One. 2010 May 26;5(5):e10836. doi: 10.1371/journal.pone.0010836.


Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs.

Freeman SA, McLeod SJ, Dukowski J, Austin P, Lee CC, Millen-Martin B, Kubes P, McCafferty DM, Gold MR, Roskelley CD.

Cancer Res. 2010 Jun 1;70(11):4590-601. doi: 10.1158/0008-5472.CAN-09-3414. Epub 2010 May 18.


Primary ovarian mucinous carcinoma of intestinal type: significance of pattern of invasion and immunohistochemical expression profile in a series of 31 cases.

Tabrizi AD, Kalloger SE, Köbel M, Cipollone J, Roskelley CD, Mehl E, Gilks CB.

Int J Gynecol Pathol. 2010 Mar;29(2):99-107. doi: 10.1097/PGP.0b013e3181bbbcc1.


Chemical synthesis and biological activity of the neopetrosiamides and their analogues: revision of disulfide bond connectivity.

Liu H, Boudreau MA, Zheng J, Whittal RM, Austin P, Roskelley CD, Roberge M, Andersen RJ, Vederas JC.

J Am Chem Soc. 2010 Feb 10;132(5):1486-7. doi: 10.1021/ja9102925.


Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis.

Kemmer D, McHardy LM, Hoon S, Rebérioux D, Giaever G, Nislow C, Roskelley CD, Roberge M.

BMC Microbiol. 2009 Jan 14;9:9. doi: 10.1186/1471-2180-9-9.


Gonadotropin releasing hormone receptor gene and protein expression and immunohistochemical localization in bovine uterus and oviducts.

Singh R, Graves ML, Roskelley CD, Giritharan G, Rajamahendran R.

Domest Anim Endocrinol. 2008 Apr;34(3):319-26. Epub 2007 Oct 24.


The morphogenic function of E-cadherin-mediated adherens junctions in epithelial ovarian carcinoma formation and progression.

Wu C, Cipollone J, Maines-Bandiera S, Tan C, Karsan A, Auersperg N, Roskelley CD.

Differentiation. 2008 Feb;76(2):193-205. Epub 2007 Jul 2.


Regulation of the BRCA1 promoter in ovarian surface epithelial cells and ovarian carcinoma cells.

Graves ML, Zhou L, MacDonald G, Mueller CR, Roskelley CD.

FEBS Lett. 2007 May 1;581(9):1825-33. Epub 2007 Apr 4.


Strongylophorine-26, an inhibitor of cancer cell Invasion: SAR revealed by synthesis of analogues.

Warabi K, Patrick BO, Austin P, Roskelley CD, Roberge M, Andersen RJ.

J Nat Prod. 2007 May;70(5):736-40. Epub 2007 Apr 4.


The CD34-related molecule podocalyxin is a potent inducer of microvillus formation.

Nielsen JS, Graves ML, Chelliah S, Vogl AW, Roskelley CD, McNagny KM.

PLoS One. 2007 Feb 21;2(2):e237.

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