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Results: 1 to 20 of 29


Strategies from UW-Madison for rescuing biomedical research in the US.

Kimble J, Bement WM, Chang Q, Cox BL, Drinkwater NR, Gourse RL, Hoskins AA, Huttenlocher A, Kreeger PK, Lambert PF, Mailick MR, Miyamoto S, Moss RL, O'Connor-Giles KM, Roopra A, Saha K, Seidel HS.

Elife. 2015 Jun 30;4. doi: 10.7554/eLife.09305.


IGF1R/IRS1 signaling confers pathogenic activity on breast tumor cells lacking REST.

Meyer K, Albaugh B, Schoenike B, Roopra A.

Mol Cell Biol. 2015 Jun 22. pii: MCB.01149-14. [Epub ahead of print]


Two Isoforms of the RNA Binding Protein, Coding Region Determinant-binding Protein (CRD-BP/IGF2BP1), Are Expressed in Breast Epithelium and Support Clonogenic Growth of Breast Tumor Cells.

Fakhraldeen SA, Clark RJ, Roopra A, Chin EN, Huang W, Castorino J, Wisinski KB, Kim T, Spiegelman VS, Alexander CM.

J Biol Chem. 2015 May 22;290(21):13386-400. doi: 10.1074/jbc.M115.655175. Epub 2015 Apr 10.


Syndecan-1 is required to maintain intradermal fat and prevent cold stress.

Kasza I, Suh Y, Wollny D, Clark RJ, Roopra A, Colman RJ, MacDougald OA, Shedd TA, Nelson DW, Yen MI, Yen CL, Alexander CM.

PLoS Genet. 2014 Aug 7;10(8):e1004514. doi: 10.1371/journal.pgen.1004514. eCollection 2014 Aug.


Tumor suppressive function of mir-205 in breast cancer is linked to HMGB3 regulation.

Elgamal OA, Park JK, Gusev Y, Azevedo-Pouly AC, Jiang J, Roopra A, Schmittgen TD.

PLoS One. 2013 Oct 2;8(10):e76402. doi: 10.1371/journal.pone.0076402. eCollection 2013.


Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling.

Potter WB, Basu T, O'Riordan KJ, Kirchner A, Rutecki P, Burger C, Roopra A.

PLoS Biol. 2013;11(8):e1001627. doi: 10.1371/journal.pbio.1001627. Epub 2013 Aug 13.


MicroRNA miR-29c down-regulation leading to de-repression of its target DNA methyltransferase 3a promotes ischemic brain damage.

Pandi G, Nakka VP, Dharap A, Roopra A, Vemuganti R.

PLoS One. 2013;8(3):e58039. doi: 10.1371/journal.pone.0058039. Epub 2013 Mar 13.


Epigenetics and epilepsy.

Roopra A, Dingledine R, Hsieh J.

Epilepsia. 2012 Dec;53 Suppl 9:2-10. doi: 10.1111/epi.12030. Review.


A REST derived gene signature stratifies glioblastomas into chemotherapy resistant and responsive disease.

Wagoner MP, Roopra A.

BMC Genomics. 2012 Dec 7;13:686. doi: 10.1186/1471-2164-13-686.


Endogenous fluorescence signatures in living pluripotent stem cells change with loss of potency.

Squirrell JM, Fong JJ, Ariza CA, Mael A, Meyer K, Shevde NK, Roopra A, Lyons GE, Kamp TJ, Eliceiri KW, Ogle BM.

PLoS One. 2012;7(8):e43708. doi: 10.1371/journal.pone.0043708. Epub 2012 Aug 29.


Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons.

Ryan SD, Britigan EM, Zasadil LM, Witte K, Audhya A, Roopra A, Weaver BA.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):E2205-14. doi: 10.1073/pnas.1201911109. Epub 2012 Jul 9.


Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors.

Gunsalus KT, Wagoner MP, Meyer K, Potter WB, Schoenike B, Kim S, Alexander CM, Friedl A, Roopra A.

Cancer Res. 2012 Jul 1;72(13):3207-16. doi: 10.1158/0008-5472.CAN-11-1639. Epub 2012 Apr 24.


A phenotypic mouse model of basaloid breast tumors.

Kim S, Roopra A, Alexander CM.

PLoS One. 2012;7(2):e30979. doi: 10.1371/journal.pone.0030979. Epub 2012 Feb 9.


The transcription factor REST is lost in aggressive breast cancer.

Wagoner MP, Gunsalus KT, Schoenike B, Richardson AL, Friedl A, Roopra A.

PLoS Genet. 2010 Jun 10;6(6):e1000979. doi: 10.1371/journal.pgen.1000979.


Metabolic regulation of neuronal plasticity by the energy sensor AMPK.

Potter WB, O'Riordan KJ, Barnett D, Osting SM, Wagoner M, Burger C, Roopra A.

PLoS One. 2010 Feb 1;5(2):e8996. doi: 10.1371/journal.pone.0008996.


Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models.

Stafstrom CE, Ockuly JC, Murphree L, Valley MT, Roopra A, Sutula TP.

Ann Neurol. 2009 Apr;65(4):435-47. doi: 10.1002/ana.21603.


Seizure suppression via glycolysis inhibition with 2-deoxy-D-glucose (2DG).

Stafstrom CE, Roopra A, Sutula TP.

Epilepsia. 2008 Nov;49 Suppl 8:97-100. doi: 10.1111/j.1528-1167.2008.01848.x. Review.


2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure.

Garriga-Canut M, Schoenike B, Qazi R, Bergendahl K, Daley TJ, Pfender RM, Morrison JF, Ockuly J, Stafstrom C, Sutula T, Roopra A.

Nat Neurosci. 2006 Nov;9(11):1382-7. Epub 2006 Oct 15.


In vivo detection of Egr2 binding to target genes during peripheral nerve myelination.

Jang SW, LeBlanc SE, Roopra A, Wrabetz L, Svaren J.

J Neurochem. 2006 Sep;98(5):1678-87.


Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes.

Roopra A, Qazi R, Schoenike B, Daley TJ, Morrison JF.

Mol Cell. 2004 Jun 18;14(6):727-38.

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