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Results: 1 to 20 of 22


Reconstructing Native American migrations from whole-genome and whole-exome data.

Gravel S, Zakharia F, Moreno-Estrada A, Byrnes JK, Muzzio M, Rodriguez-Flores JL, Kenny EE, Gignoux CR, Maples BK, Guiblet W, Dutil J, Via M, Sandoval K, Bedoya G; 1000 Genomes Project, Oleksyk TK, Ruiz-Linares A, Burchard EG, Martinez-Cruzado JC, Bustamante CD.

PLoS Genet. 2013;9(12):e1004023. doi: 10.1371/journal.pgen.1004023. Epub 2013 Dec 26.


Prevalence of the apolipoprotein E Arg145Cys dyslipidemia at-risk polymorphism in African-derived populations.

Abou Ziki MD, Strulovici-Barel Y, Hackett NR, Rodriguez-Flores JL, Mezey JG, Salit J, Radisch S, Hollmann C, Chouchane L, Malek J, Zirie MA, Jayyuosi A, Gotto AM Jr, Crystal RG.

Am J Cardiol. 2014 Jan 15;113(2):302-8. doi: 10.1016/j.amjcard.2013.09.021. Epub 2013 Oct 3.


Exome sequencing identifies potential risk variants for Mendelian disorders at high prevalence in Qatar.

Rodriguez-Flores JL, Fakhro K, Hackett NR, Salit J, Fuller J, Agosto-Perez F, Gharbiah M, Malek JA, Zirie M, Jayyousi A, Badii R, Al-Nabet Al-Marri A, Chouchane L, Stadler DJ, Mezey JG, Crystal RG.

Hum Mutat. 2014 Jan;35(1):105-16. doi: 10.1002/humu.22460. Epub 2013 Nov 10.


Exome sequencing of only seven Qataris identifies potentially deleterious variants in the Qatari population.

Rodriguez-Flores JL, Fuller J, Hackett NR, Salit J, Malek JA, Al-Dous E, Chouchane L, Zirie M, Jayoussi A, Mahmoud MA, Crystal RG, Mezey JG.

PLoS One. 2012;7(11):e47614. doi: 10.1371/journal.pone.0047614. Epub 2012 Nov 6.


Inferring genome-wide patterns of admixture in Qataris using fifty-five ancestral populations.

Omberg L, Salit J, Hackett N, Fuller J, Matthew R, Chouchane L, Rodriguez-Flores JL, Bustamante C, Crystal RG, Mezey JG.

BMC Genet. 2012 Jun 26;13:49. doi: 10.1186/1471-2156-13-49.


RNA-Seq quantification of the human small airway epithelium transcriptome.

Hackett NR, Butler MW, Shaykhiev R, Salit J, Omberg L, Rodriguez-Flores JL, Mezey JG, Strulovici-Barel Y, Wang G, Didon L, Crystal RG.

BMC Genomics. 2012 Feb 29;13:82. doi: 10.1186/1471-2164-13-82.


Human dopamine β-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure.

Chen Y, Zhang K, Wen G, Rao F, Sanchez AP, Wang L, Rodriguez-Flores JL, Mahata M, Mahata SK, Waalen J, Ziegler MG, Hamilton BA, O'Connor DT.

Am J Hypertens. 2011 Jan;24(1):24-32. doi: 10.1038/ajh.2010.186. Epub 2010 Sep 2.


Human tyrosine hydroxylase natural allelic variation: influence on autonomic function and hypertension.

Rao F, Zhang K, Zhang L, Rana BK, Wessel J, Fung MM, Rodriguez-Flores JL, Taupenot L, Ziegler MG, O'Connor DT.

Cell Mol Neurobiol. 2010 Nov;30(8):1391-4. doi: 10.1007/s10571-010-9535-7. Epub 2010 Jun 23.


Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension.

Zhang K, Rao F, Wang L, Rana BK, Ghosh S, Mahata M, Salem RM, Rodriguez-Flores JL, Fung MM, Waalen J, Tayo B, Taupenot L, Mahata SK, O'Connor DT.

J Am Coll Cardiol. 2010 Apr 6;55(14):1463-75. doi: 10.1016/j.jacc.2009.11.064.


Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach.

Rodríguez-Flores JL, Zhang K, Kang SW, Wen G, Ghosh S, Friese RS, Mahata SK, Subramaniam S, Hamilton BA, O'Connor DT.

Mamm Genome. 2010 Apr;21(3-4):195-204. doi: 10.1007/s00335-010-9253-y. Epub 2010 Mar 5.


Human tyrosine hydroxylase natural genetic variation: delineation of functional transcriptional control motifs disrupted in the proximal promoter.

Zhang K, Zhang L, Rao F, Brar B, Rodriguez-Flores JL, Taupenot L, O'Connor DT.

Circ Cardiovasc Genet. 2010 Apr;3(2):187-98. doi: 10.1161/CIRCGENETICS.109.904813. Epub 2010 Feb 2.


Pro-hormone secretogranin II regulates dense core secretory granule biogenesis in catecholaminergic cells.

Courel M, Soler-Jover A, Rodriguez-Flores JL, Mahata SK, Elias S, Montero-Hadjadje M, Anouar Y, Giuly RJ, O'Connor DT, Taupenot L.

J Biol Chem. 2010 Mar 26;285(13):10030-43. doi: 10.1074/jbc.M109.064196. Epub 2010 Jan 8.


Autonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin B.

Zhang K, Rao F, Rana BK, Gayen JR, Calegari F, King A, Rosa P, Huttner WB, Stridsberg M, Mahata M, Vaingankar S, Mahboubi V, Salem RM, Rodriguez-Flores JL, Fung MM, Smith DW, Schork NJ, Ziegler MG, Taupenot L, Mahata SK, O'Connor DT.

Circ Cardiovasc Genet. 2009 Feb;2(1):46-56. doi: 10.1161/CIRCGENETICS.108.785659. No abstract available.


Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure.

Chen Y, Wen G, Rao F, Zhang K, Wang L, Rodriguez-Flores JL, Sanchez AP, Mahata M, Taupenot L, Sun P, Mahata SK, Tayo B, Schork NJ, Ziegler MG, Hamilton BA, O'Connor DT.

J Hypertens. 2010 Jan;28(1):76-86. doi: 10.1097/HJH.0b013e328332bc87.


Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo.

Wang L, Rao F, Zhang K, Mahata M, Rodriguez-Flores JL, Fung MM, Waalen J, Cockburn MG, Hamilton BA, Mahata SK, O'Connor DT.

J Am Coll Cardiol. 2009 Sep 1;54(10):944-54. doi: 10.1016/j.jacc.2009.05.035. Erratum in: J Am Coll Cardiol. 2009 Oct 6;54(15):1482.


Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides.

Biswas N, Rodriguez-Flores JL, Courel M, Gayen JR, Vaingankar SM, Mahata M, Torpey JW, Taupenot L, O'Connor DT, Mahata SK.

Endocrinology. 2009 Aug;150(8):3547-57. doi: 10.1210/en.2008-1613. Epub 2009 Apr 16.


Adrenergic polymorphism and the human stress response.

Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork NJ, Taupenot L, Ziegler MG, O'Connor DT.

Ann N Y Acad Sci. 2008 Dec;1148:282-96. doi: 10.1196/annals.1410.085.


Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.

Chen Y, Rao F, Rodriguez-Flores JL, Mahata M, Fung MM, Stridsberg M, Vaingankar SM, Wen G, Salem RM, Das M, Cockburn MG, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, Taupenot L, O'Connor DT.

J Am Coll Cardiol. 2008 Oct 28;52(18):1468-81. doi: 10.1016/j.jacc.2008.07.047.


Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure.

Chen Y, Rao F, Rodriguez-Flores JL, Mahapatra NR, Mahata M, Wen G, Salem RM, Shih PA, Das M, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, O'Connor DT.

Kidney Int. 2008 Jul;74(1):115-25. doi: 10.1038/ki.2008.113. Epub 2008 Apr 23. Erratum in: Kidney Int. 2009 Jun;75(11):1237.


Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk.

Zhang L, Rao F, Zhang K, Khandrika S, Das M, Vaingankar SM, Bao X, Rana BK, Smith DW, Wessel J, Salem RM, Rodriguez-Flores JL, Mahata SK, Schork NJ, Ziegler MG, O'Connor DT.

J Clin Invest. 2007 Sep;117(9):2658-71.

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