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Results: 1 to 20 of 102


Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity.

Pope WH, Bowman CA, Russell DA, Jacobs-Sera D, Asai DJ, Cresawn SG, Jacobs WR, Hendrix RW, Lawrence JG, Hatfull GF; Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science; Phage Hunters Integrating Research and Education; Mycobacterial Genetics Course.

Elife. 2015 Apr 28;4:e06416. doi: 10.7554/eLife.06416.


Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation.

Imagawa K, de Andrés MC, Hashimoto K, Itoi E, Otero M, Roach HI, Goldring MB, Oreffo RO.

Arthritis Rheumatol. 2014 Nov;66(11):3040-51. doi: 10.1002/art.38774.


Evaluating the role of fluorodeoxyglucose positron emission tomography-computed tomography in multi-disciplinary team recommendations for oesophago-gastric cancer.

Blencowe NS, Whistance RN, Strong S, Hotton EJ, Ganesh S, Roach H, Callaway M, Blazeby JM.

Br J Cancer. 2013 Sep 17;109(6):1445-50. doi: 10.1038/bjc.2013.478. Epub 2013 Aug 20.


Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites.

Hashimoto K, Otero M, Imagawa K, de Andrés MC, Coico JM, Roach HI, Oreffo RO, Marcu KB, Goldring MB.

J Biol Chem. 2013 Apr 5;288(14):10061-72. doi: 10.1074/jbc.M112.421156. Epub 2013 Feb 15.


Epigenetic regulation during fetal femur development: DNA methylation matters.

de Andrés MC, Kingham E, Imagawa K, Gonzalez A, Roach HI, Wilson DI, Oreffo RO.

PLoS One. 2013;8(1):e54957. doi: 10.1371/journal.pone.0054957. Epub 2013 Jan 28.


Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes.

de Andrés MC, Imagawa K, Hashimoto K, Gonzalez A, Roach HI, Goldring MB, Oreffo RO.

Arthritis Rheum. 2013 Mar;65(3):732-42. doi: 10.1002/art.37806.


The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial.

Baigent C, Landray MJ, Reith C, Emberson J, Wheeler DC, Tomson C, Wanner C, Krane V, Cass A, Craig J, Neal B, Jiang L, Hooi LS, Levin A, Agodoa L, Gaziano M, Kasiske B, Walker R, Massy ZA, Feldt-Rasmussen B, Krairittichai U, Ophascharoensuk V, Fellström B, Holdaas H, Tesar V, Wiecek A, Grobbee D, de Zeeuw D, Grönhagen-Riska C, Dasgupta T, Lewis D, Herrington W, Mafham M, Majoni W, Wallendszus K, Grimm R, Pedersen T, Tobert J, Armitage J, Baxter A, Bray C, Chen Y, Chen Z, Hill M, Knott C, Parish S, Simpson D, Sleight P, Young A, Collins R; SHARP Investigators.

Lancet. 2011 Jun 25;377(9784):2181-92. doi: 10.1016/S0140-6736(11)60739-3. Epub 2011 Jun 12.


Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis.

de Andrés MC, Imagawa K, Hashimoto K, Gonzalez A, Goldring MB, Roach HI, Oreffo RO.

Biochem Biophys Res Commun. 2011 Apr 1;407(1):54-9. doi: 10.1016/j.bbrc.2011.02.101. Epub 2011 Feb 23.


Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.

Goldring MB, Otero M, Plumb DA, Dragomir C, Favero M, El Hachem K, Hashimoto K, Roach HI, Olivotto E, Borzì RM, Marcu KB.

Eur Cell Mater. 2011 Feb 24;21:202-20.


The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes--implications for osteoarthritis.

Imagawa K, de Andrés MC, Hashimoto K, Pitt D, Itoi E, Goldring MB, Roach HI, Oreffo RO.

Biochem Biophys Res Commun. 2011 Feb 18;405(3):362-7. doi: 10.1016/j.bbrc.2011.01.007. Epub 2011 Jan 8.


Epigenetic modifiers influence lineage commitment of human bone marrow stromal cells: Differential effects of 5-aza-deoxycytidine and trichostatin A.

El-Serafi AT, Oreffo RO, Roach HI.

Differentiation. 2011 Jan;81(1):35-41. doi: 10.1016/j.diff.2010.09.183.


DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes.

Hashimoto K, Oreffo RO, Gibson MB, Goldring MB, Roach HI.

Arthritis Rheum. 2009 Nov;60(11):3303-13. doi: 10.1002/art.24882.


Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage.

da Silva MA, Yamada N, Clarke NM, Roach HI.

J Orthop Res. 2009 May;27(5):593-601. doi: 10.1002/jor.20799.


Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation.

Cheung KS, Hashimoto K, Yamada N, Roach HI.

Rheumatol Int. 2009 Mar;29(5):525-34. doi: 10.1007/s00296-008-0744-z. Epub 2008 Oct 22.


The complex pathology of osteoarthritis: even mitochondria are involved.

Roach HI.

Arthritis Rheum. 2008 Aug;58(8):2217-8. doi: 10.1002/art.23635. No abstract available.


More than just stones: a pictorial review of common and less common gallbladder pathologies.

Ash-Miles J, Roach H, Virjee J, Callaway M.

Curr Probl Diagn Radiol. 2008 Sep-Oct;37(5):189-202. doi: 10.1067/j.cpradiol.2007.12.001.


Potential directions for drug development for osteoarthritis.

Roach HI.

Expert Opin Drug Discov. 2008 May;3(5):475-86. doi: 10.1517/17460441.3.5.475.


Jejunal diverticulitis: an unusual cause of an intra-abdominal abscess - coronal Computed Tomography reconstruction can aid the diagnosis.

Mortimer A, Harding J, Roach H, Callaway M, Virjee J.

J Radiol Case Rep. 2008;2(5):15-8. doi: 10.3941/jrcr.v2i5.85. Epub 2008 Nov 1.

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